OXIDATIVE STRESS AND LEVEL OF IRON INDICES IN CORONARY HEART DISEASE PATIENTS

Authors

  • Muhammad Ahmad
  • Mudassir Ahmad Khan
  • Abdus Sattar Khan

Abstract

Objective: Oxidative stress is characterized by an increased concentration of oxygen free radicalswhich can cause a critical, or even an irreversible, cell injury. The study was designed to determineand compare the levels of oxidative stress and iron indices in Coronary Heart Disease and healthyindividuals. Material and Methods: Blood malondialdehyde, iron, total iron-binding capacity,transferrin saturation and ferretin levels were determined in 140 Coronary Heart Disease and 100healthy subjects. Results: Values of blood malondialdehyde, iron, transferrin saturation and ferretinwere observed to be significantly increased with exception of total iron-binding capacity, which wassignificantly decreased (p0.005) in Coronary Heart Disease patients when compared with normalhealthy controls. Conclusion: Elevated serum malondialdehyde, iron concentration and body ironstores in patients reveal a possible role of iron indices in the development of coronaryatherosclerosis. Therefore, it is suggested by this study that levels of malondialdehyde andbiochemical markers of body iron stores can be used as an early investigative tool for assessing theoxidative stress in coronary heart disease.Keywords: Coronary Heart Disease, Oxidative Stress, Malondialdehyde, Iron, Total iron-bindingcapacity, Transferrin Saturation, Ferritin

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Published

2009-06-01

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