HEPATITIS C: FREQUENCY AND RISK FACTORS ASSOCIATED WITH SERO-POSITIVITY AMONG ADULTS IN LARKANA CITY

Authors

  • Fida Hussain Shaikh
  • Hakim Ali Abro
  • Mumtaz Ali Chhutto
  • Parvez Ahmed Abbasi
  • Abdul Wahab Shaikh
  • Sheeraz Ali Buriro

Abstract

Background: Viral hepatitis is a major public health problem. Infection with Hepatitis C virus(HCV) leads to chronicity and there are about 170 million people infected with HCV. Up to 70%of chronically infected individuals develop active liver disease. The Objective of the study was tofind out the frequency of Anti-HCV seropositivity and risk factors of Hepatitis C Virus (HCV)transmission in people of Larkana city. Method: The study was conducted at Larkana from April2006 to April 2007. Camps were established in the main general practitioners’ clinics. Aquestionnaire about knowledge of HCV and risk factors of its transmission was administered tosubjects. Descriptive statistics were done by SPSS-10. Result: Total 450 cases were enrolled intothis study. They were divided into 3 age groups. Eighty-nine (19.8%) cases were in age group <20years, 262 (58.2%) were in age group 20–40 years and 99 (22.0%) were in age group >40 years.There were 353 (78.4%) male and 97 (21.6%) female subjects, out of these 450 cases 30 (6.6%)were positive for Anti-HCV. A number of risk factors of HCV transmission were present in thesecases. History of therapeutic injections was present in 72 cases and 35 cases used public barberservices. Conclusion: History of therapeutic injections and use of barber services for shave werethe most frequent risk factors in our study.Keywords: Risk factors, HCV, Sero-positivity, Hepatitis, Cirrhosis, Hepatocellular Carcinoma

References

Perlman BL. Hepatitis C infection: a clinical review. South Med

J 2004;97(4):364–73.

WHO. Global Surveillance and Control of hepatitis C: Report of

a WHO Consultation organized in collaboration with the Viral

Hepatitis Prevention Board, Antwerp. Belgium. J Viral Hepat

;6:35–47.

Conry-Cantilena C, VanRaden M, Gibble J, Melpolder J, Shakil

AO, Viladomiu L, et al. Routes of infection, viremia and liver

disease in blood donors found to have hepatitis C virus infection.

N Engl J Med 1996;334:1691–6.

Zein NN. The epidemiology and natural history of hepatitis C

virus infection. Cleve Clin J Med 2003;70 (Suppl 4):S2–6.

Umar M, Bushra HT, Shuaib A, Anwar A, Shah NH. Spectrum

of chronic liver disease due to hepatitis C virus infection. J Coll

Physicians Surg Pak 2000;10:380–3.

Haider Z, Khan AA, Rehman K, Janjua MI, Iqbal J, Chishti A, et

al. Sero-diagnosis for viral hepatitis in 93 patients admitted with

acute hepatitis in three different teaching hospitals in Lahore. J

Pak Med Assoc 1994;44:182–4.

Hamid S, Tabbasum S, Jafri W. Hepatitis C has replaced

Hepatitis B as the major cause of chronic liver disease in

Pakistan. Hepatology 1999;30:212A.

Chohan AR, Umar M, Khaar B, Khurram M, Zahid M, Shah SF,

et al. Demographic features of hepatocellular carcinoma. A study

of 30 cases. J Rawl Med Coll 2001;5(2):81–3.

Lubey S, Khanani R, Zia M, Vellani Z, Ali M, Qureshi H, et al.

Evaluation of blood bank practices in Karachi, Pakistan and the

government’s response. Health Policy Plan 2000;15:217–22.

Khan AJ, Luby SP, Fikree F, Karim A, Obaid S, Dellawala S, et

al. Unsafe injections and the transmission of hepatitis B and C in

a periurban community in Pakistan. Bull World Health Organ

;78:956–63.

Jafri W, Jafri N, Yakoob J, Islam M, Tirmizi SFA, Jafar T, et al.

Hepatitis B and C: prevalence and risk factors associated with

seropositivity among children in Karachi, Pakistan. BMC Infect

Dis 2006;6:101.

Bari A, Akhtar S, Rahbar MH, Luby SP. Risk factors for

hepatitis C virus infection in male adults in RawalpindiIslamabad, Pakistan. Trop Med Int Health 2001;6:732–8.

Sheikh SN, Tayyab N, Jaffery G, Tasneem T, Sattar A, Ali I. AntiHCV detection. A comparison between methodology: Elisa Vs

Dipstick Assay. J Ayub Med Coll Abbottabad 1999;11(1):30–3.

Qureshi M, Bengali K. The State of Education, In: Social

Development in Pakistan, Annual Review 2002–2003. Social

Policy and Development Centre Karachi, Times Press: iii-iv.

Hepatitis C: global prevalence. Wkly Epidemiol Rec

;72:341–4.

Roy KM, Goldberg D, Taylor A, Mills P. Investigating the

source of hepatitis C virus infection among individuals whose

route of infection is undefined: a study of ten cases. Scand J

Infect Dis 2003;35:326–8.

Luby SP, Qamruddin K, Shah AA, Omair A, Pasha O, Khan AJ,

et al. The relationship between therapeutic injections and high

prevalence of hepatitis C infection in Hafizabad, Pakistan.

Epidemiol Infect 1997;119:349–56.

Shaikh MA, Shaikh WM, Solangi GA, Abro H. Frequency and

transmission in mode of hepatitis C virus in northern Sindh. J

Coll Physicians Surg Pak 2003;13:691–3.

Ahmad K. Pakistan: a cirrhotic state? Lancet 2004;364:1843–4.

Khan AJ. Unsafe injections and the transmission of hepatitis B

and C in a Periurban community in Pakistan. Bull World Health

Organ 2000;78:956–63.

Published

2009-06-01