• Haji Khan Khoharo
  • Shuaib Ansari
  • Allauddin Abro
  • Fatima Qureshi


Accidental or intentional Isoniazid poisoning may manifest within half to three hours asintractable seizure, acidosis, and coma. Single high dose of pyridoxine was used as an antidotewith good response as reported earlier. Ingestion of more than 80 mg/kg body weight producessevere central nervous system symptoms and a dose of 125 mg/kg is potentially lethal if notpromptly treated. We report a case of suicidal attempt with use of Isoniazid, who developed grandmal seizures and was controlled with diazepam and symptomatic treatment.Keywords: Isoniazid, INH, grand mal, suicidal attempt, poisoning


Kent R, Olson H. Poisoning. In: Tierney LM Jr, Mc-Phee

SJ, Papadakis MA, eds. Current medical diagnosis and

treatment. 47th Ed. New York: McGraw-Hill;2008.p.1375.

Agrawal RL, Dwivedi NC, Agrawal M, Jain S, Agrawal

A. Accidental isoniazid poisoning—a report. Indian J

Tuberc 2008;55:94–6

Watkins RC, Hambrick EL, Benjamin G, Chavada S.

Isoniazid toxicity presenting as seizures and metabolic

acidosis. J Natl Med Assoc 1990;82:62–4.

Orlowski JP, Paganini EP, Pippenger CE. Treatment of a

potentially lethal dose of isoniazid ingestion. Ann Emerg

Med 1988;17:73–6.

Gilhotra R, Malik SK, Sigh S, Sharma BK. Acute

isoniazid toxicity-report of 2 cases and review of literature.

Int J Clin Pharmacol Ther Toxicol 1987;25:259–61.

Tai DYH, Yeo JKS, Eng PCT, Wang YT. Intentional

overdosage with INH: case report and review of literature.

Singapore Med J 1996;37:222–5.

Sood AK, Dua A, Mahajan A. Management of isoniazid

poisoning--case report. Indian J Med Sci 1996;50:247–9.

Wason S. Lacouture PC and Love Joy F.H. Jr. Single high

dose Pyridoxine treatment for Isoniazid overdose. JAMA


Prabhakaran E.A. Case of Isoniazid poisoning death

report. J Assoc Physicians India 1989;37:29.

Ansari MM, Beg MH, Haleem S. Acute isoniazid

poisoning. Indian J Tuberc 1991;38:37–8.



Most read articles by the same author(s)