SUICIDAL ISONIAZID POISONING
AbstractAccidental or intentional Isoniazid poisoning may manifest within half to three hours asintractable seizure, acidosis, and coma. Single high dose of pyridoxine was used as an antidotewith good response as reported earlier. Ingestion of more than 80 mg/kg body weight producessevere central nervous system symptoms and a dose of 125 mg/kg is potentially lethal if notpromptly treated. We report a case of suicidal attempt with use of Isoniazid, who developed grandmal seizures and was controlled with diazepam and symptomatic treatment.Keywords: Isoniazid, INH, grand mal, suicidal attempt, poisoning
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