SINISTER CAUSE OF HIGH BONE MINERAL DENSITY ON DUAL ENERGY X-RAY ABSORPTIOMETRY

Authors

  • Mairah Razi Shaukat Khanum Hospital, Lahore
  • Aamna Hassan Shaukat Khanum Hospital, Lahore

Abstract

Dual energy X-ray absorptiometry (DXA) has an established, well standardized role in the measurement of bone mineral density (BMD).  In routine clinical practice, the main focus of bone densitometry is to identify low bone mass for the diagnosis and monitoring of osteoporosis particularly in postmenopausal females and in high risk individuals. Less commonly, elevated BMD can also be seen on routine DXA scanning usually due to degenerative disease. However, a range of other skeletal disorders can also lead to high BMD. Careful recognition of various artefacts and pathologic processes that can falsely elevate the BMD is essential for accurate DXA scan analysis and reporting. We present a case of high BMD in a patient of prostate carcinoma with widespread sclerotic metastases.

Author Biographies

Mairah Razi, Shaukat Khanum Hospital, Lahore

FCPS II trainee in Nuclear medicine

Aamna Hassan, Shaukat Khanum Hospital, Lahore

Consultant Nuclear medicine

References

Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. Geneva, World Health Organization, 1994 (WHO Technical Report Series, No. 843).

Whyte MP. Misinterpretation of osteodensitometry with high bone density: BMD Z > or = + 2.5 is not ‘normal’. J Clin Densitom 2005;8(1):1–6.

Gregson CL, Hardcastle SA, Cooper C, Tobias JH. Friend or foe: high bone mineral density on routine bone density scanning, a review of causes and management. Rheumatology (Oxford) 2013;52(6):968–85.

Tanaka H, Furukawa Y, Fukunaga K, Fukunaga M. Bone mineral density for patients with bone metastasis of prostate cancer: a preliminary report. Adv Exp Med Biol 1992;324:217–31.

Mitchell MJ, Logan PM. Radiation-induced changes in bone. Radiographics 1998;18(5):1125–36.

Li X, Zhang Y, Kang H, Liu W, Liu P, Zhang J, et al. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem 2005;280(20):19883–7.

Gregson CL, Steel SA, O’Rourke KP, Allan K, Ayuk J, Bhalla A, et al. ‘Sink or swim’: an evaluation of the clinical characteristics of individuals with high bone mass. Osteoporos Int 2012;23(2):643–54.

El Maghraoui A, Borderie D, Cherruau B, Edouard R, Dougados M, Roux C. Osteoporosis, body composition and bone turnover in ankylosing spondylitis. J Rheumatol 1999;26(10):2205–9.

Chan FK, Tiu SC, Choi KL, Choi CH, Kong AP, Shek CC. Increased bone mineral density in patients with chronic hypoparathyroidism. J Clin Endocrinol Metab 2003;88(7):3155–9

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Published

2016-03-10