THE IMPACT OF HYPERGLYCAEMIA ON MORBIDITY AND MORTALITY OF ACUTE CORONARY SYNDROMES AND ACUTE MYOCARDIAL INFARCTION
AbstractBackground: Though diabetes and hyperglycaemia are well known risk factors for morbidityand mortality associated with Coronary Heart Disease, there are no studies published fromPakistan on the impact of non-diabetic hyperglycaemia on these indices. The present studywas undertaken to fill the gap in knowledge related to this aspect of hyperglycaemia inPakistani patients. Methods: We studied 166 patients admitted to our coronary care unit fromMay 2008 to March 2009 with acute coronary syndrome and acute myocardial infarction. Thepatients were divided into three groups (a) Diabetic group (b) Impaired glucose group and (c)Normal glucose group according to the American Diabetic Association criteria. Results: Itwas observed that with increasing level of hyperglycaemia there was an increase in themortality, with a p-value of 0.058. Hyperglycaemia was also associated with impaired leftventricular function and clinical evidence of left ventricular failure. Insulin therapy was underutilized and may have contributed to increased morbidity and mortality.Keywords: Coronary artery syndromes, Myocardial infarction, Diabetes mellitus, Hyperglycaemia
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