PATTERN OF CHANGE IN THE FREQUENCY OF HELICOBACTER PYLORI WITH PERFORATED DUODENAL ULCER
AbstractBackground: Peptic ulcers were believed to be caused by stress, dietary factors, and gastric acid,but the link between H. pylori and peptic ulcers was identified in 1983. To see the frequency ofHelicobacter pylori infection in patients with perforated duodenal ulcer and advise eradicationtherapy in these patients. This cross sectional study was conducted in Surgical Unit HayatabadMedical Complex, Peshawar, during January 2007–June 2008. Methods: A total of 50 cases wereincluded in the study. All cases presenting to our unit with acute perforated duodenal ulcer wererecruited. After resuscitation and baseline investigations, all underwent emergency laparotomy viaupper midline incision, after thorough peritoneal lavage, the perforation margins were freshenedand closed over an omental patch. Serum from every patient was tested for H. pylori andaccordingly managed. Results: Out of the 50 cases, 45 were males, and 5 were females. Ageranged from 20– 80 years old. All patients underwent emergency laparotomy. Postoperatively, allwere started on PPI treatment and serum testing for H. pylori was done. Thirty-four (68%) turnedout positive and 16 (32%) were found to be negative for H. pylori. Conclusion: There is still a highfrequency of H. pylori infection in patients with perforated duodenal ulcer. But comparing theseresults with the various data available, there is a significant decline in H pylori positive perforatedduodenal ulcer patients.Keywords: Peptic ulcer, Helicobacter pylori infection, Proton pump inhibitors
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