• Muhammad Nawaz
  • Muhammad Jehanzaib
  • Khalid Khan
  • Mohammad Zari


Background: Peptic ulcer is a sore in the protective lining (mucosal lining) of the gastrointestinaltract and develops when the lining is damaged. The objectives of this Descriptive Validational studywere to determine the validity of Barium Meal examination in the diagnosis of peptic ulcer disease incomparison to the gold standard, i.e., endoscopic evaluation in peptic ulcer disease. The study wasconducted at Radiology Department Khyber Teaching Hospital Peshawar from November 2000 toMarch 2004. Methods: A total of 115 patients with signs and symptoms of peptic ulcer disease wereselected for this study and were subjected for this diagnostic modality. The diagnosis ofbenign/malignant peptic ulcer was made by barium meal examinations. In all these patients thediagnosis was later on confirmed by endoscopy and or surgery. Results: Of the 115 patients, 80were male and 35 were female patients. Their ages ranged from 27–75 years with mean age of 49years. Fifty two patients had duodenal ulcer, 30 patients gastric ulcer, and 33 patients had normalradiological findings. In 6 out of 30 patients with gastric ulcer had radiological evidence ofmalignant gastric ulcer. Conclusion: Efficiency of Barium meal examination in diagnosis of pepticulcer is good and most of peptic ulcers can be diagnosed by this method.Keyword: Barium meal, Peptic ulcer, Endoscopy.


Steer HW. Surface morphology of gastro duodenal mucosa in

duodenal ulceration. Gut 1984;25:1203–10.

Stemmermann GN, Marcus EB, Bui st AS, Maclean CJ.

Relative impact of smoking and reduced pulmonary function

on peptic ulcer risks; a prospective study of Japanese men in

Hawai. Gastroentology 1989;96:1419–24.

Mooney C, Keenan J, Munster D , Wilson I, Allardyce R,

Bagshaw P,. Neutrophil activation by Hel icobacter Pylori.

Gut 1991;32:853–7.

Moghal N, Jafarey NA. A histological study of the effects of

non steroidal anti -inflammatory drugs (NSAIDS) on the

gastric and duodenal mucosa .J Pak Med Assoc


Hirschowitz BI. Endoscopic examination of the stomach and

duodenal cap with a fiberscope. Lancet 1961;1(7186):1074-8.

Hirschowitz BI. Development and application of Endoscopy


Heatly RV, open access upper gastrointestinal endoscopy

popular but is it right? BMJ 1993;306:1224.

Makris N, Barkun A, Crott R, Fallone CA. Cost effectiveness

of alternative approaches in t he management of dyspepsia.

Int J Technol Assess Health Care 2003;19:446–64.

Westbrook JI; Talley NJ. Diagnostic investigation rates and

use prescription and non presc ription medication amongst

dyspeptics: a population based study of 2300 Australians.

Ailment Pharmacol Ther. 2003;17:1171–8.

Fraser GM, Earnshaw PM. The double contrast barium meal:

a correlation with endoscopy. Clin Radiol 1983;34:121–31.

Cumberland DC . Fibreoptic endoscopy and radiology in the

investigation of the upper gastrointestinal tract. Clin Radiol


Ameh EA. Pep tic ulcer disease in childhood in Zaria,

Nigeria. Ann Trop Paediatr 1999;19:65–8.

Thompson G, Somers S, Stevenso n GW. Benign gastric

ulcer: a reliable radiological diagnosis. AJR 1983;141:331–3.

Levine MS. Role of the double contrast upper gastrointestinal

series in the 1990s.Gastroente rol Clin North Am


Bernersen B, Johnsen R, Straume B, Burhol PG, Jenssen TG,

Stakkevold PA. Towards a true prevalence of peptic ulcer: the

Sorresi gastrointestinal disorder study. Gut 1990;31:989–92.

Creibe J, Bugge P, Gjorup T, Lauritzen T, Bonnevie O,

Wulff HR.. Long-term prognosis of duodenal ulc er: follow

up study and survey of doctor s estimates. B r Med J


Desforges JF. Helicobacter pylori and peptic ulcer disease. N

Engl J Med 1991;324:1043–8.

Feldman M, Walker P, Green JL, Weingarden K. Life events

stress and psychosocial factor s in men with peptic ulcer

disease. A multidimensional case control stu dy.

Gastroenterology 1986;91:1370–9.

Cumberland DC. Fibreoptic endo scopy and radiology in the

investigation of the upper gas trointestinaltract. Clin Radiol


Brezina K, Kern H, Proszowski P. Result of combined

radiological and endoscopy inv estigation of the stomach.

Wien Klin Wochenschr. 1979;91:654–8.

Laufer I, The diagnostic accur acy of barium studies of the

studies of the stomach and duodenum correlatio n with the

endoscopy. Radiology 1975;115:563–73.

Cotton PB, Shorvon PJ. Analysi s of endoscopy and

radiography in the diagnosis, follow up an d treatment of

peptic ulcer disease. Clin Gastroenterol 1984;13:383–403.

Stevenson G. The distribution of gastric ulcer: double

contrast barium meal and endos copy findings. Clin Radiol.

;28: 617–24.



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