HISTOLOGICAL PATTEREN OF NEPHROTIC SYNDROME IN ELDERLY PATIENTS
AbstractBackground: Renal biopsy is a safe and informative technique that has played a key role in theevolution of nephrology as a specialty. This cross-sectional descriptive study was aimed to studythe histological pattern of nephrotic syndrome in elderly patients. Methods: This study was conductedfrom January 1998 to December 2005 (8 Years) in the Department of Nephrology, Govt. Lady ReadingHospital, Peshawar, Pakistan. We performed renal biopsy in 153 patients aged 60 years and above,admitted with nephrotic syndrome–proteinuria with protein >3 gm/24 hours with or without oedema,hypoalbuminemia, hyperlipidemia, acute nephritic syndrome–red blood cell casts or dysmorphic red cellson urine microscopy, temporally associated with acute renal failure with or without new onsethypertension, acute renal failure–sudden decline in renal functions developing in days to weeks causingretention of nitrogenous wastes and rapidly progressive renal failure–sub acute decline in renal functionsdeveloping over weeks to months. Results: Significant differences in the histological pattern are noticedwhen compared with the studies of the other centres. Minimal Change Disease (MCD) was thecommonest histological pattern (40%), followed by Membranous Nephropathy (21%), CrescenticNephritis (19.6%), Focal Segmental Glomerulosclerosis (FSGS) (6.5%), Hypertensive Nephropathy(5.8%), Messangiocapillary Glomerulonephritis (MCGN) (3.9%) and Diffuse ProliferativeGlomerulonephritis (DPGN) (3.2%).Keywords: Renal Biopsy, Glomerulonephritis, Minimal Change Disease, MembranousNephropathy, Crescentic Nephritis, Focal Segmental Glomerulosclerosis, HypertensiveNephropathy, Messangiocapillary Glomerulonephritis, Diffuse Proliferative Glomerulonephritis
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