EOSINOPHILS AND EOSINOPHIL PRODUCTS IN ASTHMA
AbstractEosinophils are known to be an indirect marker of airway inflammation in asthma. It is known since long that the total eosinophil count reflects asthmatic activity and is useful for regulating steroid dosage and for early detection of exacerbations. Eosinophils are currently regarded as the effector cells responsible for much of the pathology of asthma. Eosinophil-mediated damage to the respiratory epithelium is a major pathogenetic mechanism in asthma. This article is a review of the latest works about the relationship of eosinophil and eosinophil products with asthma.
Kokuludag A, Sin A, Terzioglu E, Saydam G, Sebik F. Elevation of serum eosinophil cationic protein, soluble tumor necrosis factor receptors and soluble intercellular adhesion molecule-1 levels in acute bronchial asthma. J Investig Allergol Clin Immunol 2002;12(3):211-4
Norzila MZ, Fakes K, Henry RL, Simpson J, Gibson PG. Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma. Am J Respir Crit Care Med 2000 Mar;161(3 Pt 1):769-74
Labbe A, Aublet-Cuvelier B, Jouaville L, Beaugeon G, Fiani L, Petit I, Ouchchane L, Doly M. Prospective longitudinal study of urinary eosinophil protein X in children with asthma and chronic cough. Pediatr Pulmonol 2001 May;31(5):354-62
Stirling RG, van Rensen EL, Barnes PJ, Chung KF. Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma. Am J Respir Crit Care Med 2001 Oct 15;164(8 Pt 1):1403-9
Coyle AJ, Gutierrez-Ramos JC. Eosinophils in asthma. In: Celleular mechanisms in airway infl ammation. Eds. CP Page, KH Banner, D Spina. Birkhäuser Verlag, ISBN 3-7643-5852-1, 2000. 147-158.
Gleich GJ (1990): The eosinophil and bronchial asthma: current understanding. J Allergy Clin Immunol 85: 422-436.
Mitra SN, Slungaard A, Hazen SL. Role of eosinophil peroxidase in the origins of protein oxidation in asthma. Redox Rep 2000;5(4):215-24
Clutterbuck EJ, Sanderson CJ. Human eosinophil hematopoiesis studied in vitro by means of murine eosinophil differentiation factor (IL5): production of functionally active eosinophils from normal human bone marrow. Blood 1988;71:646-651.
Rothenberg ME. Eotaxin. An essential mediator of eosinophil trafficking into mucosal tissues. Am J Respir Cell Mol Biol. 1999;21:291-295.
Venge P. Serum measurement of eosinophil cationic protein (ECP) in bronchial asthma. Clinical and experimental allergy, 1993, 23 (suppl. 2):3-7.
Takenaka T, Okuda M, Kawabori S, Kubo K. Extracellular release of peroxidase from eosinophils by interaction with immune complexes. Clin & Exp Immunol 1977;28:56-60.
Winqvist I, Olofsson T, Olsson I. Mechanisms for eosinophil degranulation; release of the eosinophil cationic protein. Immunology 1984;51:1-8.
Giembycz MA, Lindsay MA. Pharmacology of the eosinophil. Pharmacol Rev1999;51:213-339.
Dvorak AM, Letourneau L, Login GR, Weller PF, Ackerman SJ. Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to a distinct crystalloid-free granule population in mature human eosinophils. Blood 1988;72:150- 158.
Spry C. Eosinophils: a comperhensive review and guide to the scientific and medical literature. Oxford University press Ltd., Oxford, UK. 1998.
Frigas E, Motojima S, Gleich GJ. The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma. Eur Resp J 1991;13(S):123-135.
Blom M, Tool AT, Wever PC, Wolbink GJ, Brouwer MC, Calafat J, Egesten A, Knol EF, Hack CE, Roos D, Verhoeven AJ. Human eosinophils express, relative to other circulating leukocytes, large amounts of secretory 14-kD phospholipase A2. Blood 1998;91:3037-3043.
Lundahl J, Halldén G, Hed J. Differences in intracellular pool and receptor-dependent mobilization of the adhesion-promoting glycoprotein Mac-1 between eosinophils and neutrophils. J Leukoc Biol 1993;53:336-341.
Kim J, Merry AC, Nemzek JA, Bolgos GL, Siddiqui J, Remick DG. Eotaxin represents the principal eosinophil chemoattractant in a novel murine asthma model induced by house dust containing cockroach allergens. J Immunol 2001 Sep 1;167(5):2808-15
Kumar RK, Herbert C, Yang M, Koskinen AM, McKenzie AN, Foster PS. Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma. Clin Exp Allergy 2002 Jul;32(7):1104-11
Koh YI, Choi S. Blood eosinophil counts for the prediction of the severity of exercise-induced bronchospasm in asthma. 14: Respir Med 2002 Feb;96(2):120-5
Horn BR, Robin ED, Theodore J, Van Kessel A. Total eosinophil counts in the management of bronchial asthma. N Engl J Med 1975 May 29;292(22):1152-5
Gupta S, Frenkel R, Rosenstein M, Grieco MH. Lymphocyte subpopulations, serum IgE and total eosinophil counts in patients with bronchial asthma. Clin Exp Immunol 1975 Dec;22(3):438-45
Schmekel B, Ahlner J, Malmstrom M, Venge P. Eosinophil cationic protein (ECP) in saliva: a new marker of disease activity in bronchial asthma. Respir Med 2001 Aug;95(8):670-5
Stelmach I, Grzelewski T, Stelmach W, Majak P, Jerzynska J, Gorski P, Kuna P. Effect of triamcinolone acetonide, montelukast, nedocromil sodium and formoterol on eosinophil blood counts, ECP serum levels and clinical progression of asthma in children]. Pol Merkuriusz Lek 2002 Mar;12(69):208-13
Druilhe A, Letuve S, Pretolani M. Eosinophil apoptosis in asthma. Pathol Biol (Paris) 2000 Jul;48(6):566-73
Wardlaw AJ. Eosinophil trafficking in asthma. Clin Med 2001 May-Jun;1(3):214-8
Dahl R. Monitoring bronchial asthma in the blood. Allergy, 1993, 48:77-80.
Griffin E, Hakansson L, Formgren H, Jorgensen K, Peterson C, Venge P. Blood eosinophil number and activity in relation to lung function in patients with asthma and with eosinophilia. J Allergy Clin Immunol 1991 Feb;87(2):548-57
Burrows Bl. Epidemiologic observations on eosinophilia and its relation
to respiratory disorders. American review of respiratory disease, 1980, 122(5):709-19.
Bousquet J, Chanez P, Lacoste JY, Barnéon G, Ghavanian N, Enander I et al. Eosinophilic inflammation in asthma. New Engl J Med 1990;323: 1033-1039.
DeMonchy JGR, Kauffman HF, Venge F, Koëter GH, Jansen HM, Sluiter HJ, De Vries K (1985): Bronchoalveolar eosinophilia during allergeninduced late asthmatic reactions. Rev Respir Dis 131: 373-376.
Djukanovic R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR et al. Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am Rev Respir Dis 1990;142: 863-871.
Beasley R, Roché WR, Roberts JA, Holgate ST (1989): Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989;139: 806-817.
Laitinen LA, Laitinen A, Haahtela T. Airway mucosal inflammation even in patients with newly diagnosed asthma. Am Rev Respir Dis 1993;147:697-704.
Louis R, Sele J, Henket M, Cataldo D, Bettiol J, Seiden L, Bartsch P. Sputum eosinophil count in a large population of patients with mild to moderate steroid-naive asthma: distribution and relationship with methacholine bronchial hyperresponsiveness. 5: Allergy 2002 Oct;57(10):907-12
Kivity S, Argaman A, Onn A, Shwartz Y, Man A, Greif J, Fireman E. Eosinophil influx into the airways in patients with exercise-induced asthma. Respir Med 2000 Dec;94(12):1200-5
Zhao J, Takamura M, Yamaoka A, Odajima Y, Iikura Y. Altered eosinophil levels as a result of viral infection in asthma exacerbation in childhood. 11: Pediatr Allergy Immunol 2002 Feb;13(1):47-50
Janson C, Herala M. Blood eosinophil count as risk factor for relapse in acute asthma. Respiratory medicine, 1992, 86(2):101-4.
Bruijnzeel PL. Contribution of eosinophil-derived mediators in asthma. Int Arch Allergy Appl Immunol 1989;90 Suppl 1:57-63
Lundgren R et al. Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids. European respiratory journal, 1988, 1(10):883-9.
Adamko D, Lacy P, Moqbel R. Mechanisms of Eosinophil Recruitment and Activation. Current Allergy and Asthma Reports 2002 2:107-116.
Onadeko BO, Khadadah ME, Mustafa HT, Ezeamuzie CI, Marouf R, Khamis A, et al. Serum eosinophil cationic protein as a predictor of disease activity in acute and chronic asthma. East Afr Med J 1999 Sep;76(9):524-9
Nutku E, Gounni AS, Olivenstein R, Hamid Q. Evidence for expression of eosinophil-associated IL-12 messenger RNA and immunoreactivity in bronchial asthma. J Allergy Clin Immunol 2000 Aug;106(2):288-92
Kankaanranta H, Lindsay MA, Giembycz MA, Zhang X, Moilanen E, Barnes PJ et al. Asthma attack severity and urinary concentration of Eosinophil X protein in children. Allergol Immunopathol (Madr) 2002 Jul-Aug;30(4):225-31
Foresi A, Teodoro C, Leone C, Pelucchi A, D'Ippolito R, Chetta A, Olivieri D. Eosinophil apoptosis in induced sputum from patients with seasonal allergic rhinitis and with asymptomatic and symptomatic asthma. Ann Allergy Asthma Immunol 2000 Apr;84(4):411-6
Kuo HP, Wang CH, Lin HC, Hwang KS, Liu SL, Chung KF. Interleukin-5 in growth and differentiation of blood eosinophil progenitors in asthma: effect of glucocorticoids. Br J Pharmacol 2001 Dec;134(7):1539-47
Badr-el-Din OM, el-Sawy IH, el-Azzouni OE, Badr-el-Din MM, Salem AM. Eosinophil cationic protein as a serological marker of disease activity in childhood bronchial asthma. East Mediterr Health J 1999 Jul;5(4):664-75
Jahnz-Ro yk K, Plusa T, Mierzejewska J. Eotaxin in serum of patients with asthma or chronic obstructive pulmonary disease: relationship with eosinophil cationic protein and lung function. Mediators Inflamm 2000;9(3-4):175-9
Koller DY, Halmerbauer G, Frischer T, Roithner B. Assessment of eosinophil granule proteins in various body fluids: is there a relation to clinical variables in childhood asthma? Clin Exp Allergy 1999 Jun;29(6):786-93
Perfetti L, Galdi E, Brame B, Speciale L, Moscato G. Serum eosinophil cationic protein (sECP) in subjects with a history of asthma symptoms with or without rhinitis. Allergy 1999 Sep;54(9):962-7
Melbostad E, Venge P, Danielsen TA, Kjuus H. Serum eosinophil cationic protein in asthma of farmers. Scand J Clin Lab Invest 2000 Apr;60(2):111-8
Marguet C, Dean TP, Basuyau JP, Warner JO. Eosinophil cationic protein and interleukin-8 levels in bronchial lavage fluid from children with asthma and infantile wheeze. Pediatr Allergy Immunol 2001 Feb;12(1):27-33
Ishigaki N, Masuhara C, Sakamaki K, Ishikawa Y, Ohta K, Koike R, Mikuni K, Haruna H, Awa S. Relation between serum eosinophil cationic protein (ECP) level and asthma attack in children. Arerugi 2000 Nov;49(11):1093-103
Matsumoto H, Niimi A, Minakuchi M, Izumi T. Serum eosinophil cationic protein levels measured during exacerbation of asthma: characteristics of patients with low titres. Clin Exp Allergy 2001 Apr;31(4):637-43
Sorkness C, McGill K, Busse WW. Evaluation of serum eosinophil cationic protein as a predictive marker for asthma exacerbation in patients with persistent disease. Clin Exp Allergy 2002 Sep;32(9):1355-9
Filley WV, Holley KE, Kephart GM, Gleich GJ.Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma. Lancet 1982 Jul 3;2(8288):11-6
Morioka J, Kurosawa M, Inamura H, Nakagami R, Mizushima Y, Chihara J, et al. Development of a novel enzyme-linked immunosorbent assay for blood and urinary eosinophil-derived neurotoxin: a preliminary study in patients with bronchial asthma. Int Arch Allergy Immunol 2000 May;122(1):49-57
Severien C, Artlich A, Jonas S, Becher G. Urinary excretion of leukotriene E4 and eosinophil protein X in children with atopic asthma. Eur Respir J 2000 Oct;16(4):588-92
Studnicka M. Urinary eosinophil protein X in children: the relationship to asthma and atopy and normal values. Allergy 2000 Jul;55(7):647-52
Oymar K. High levels of urinary eosinophil protein X in young asthmatic children predict persistent atopic asthma. Pediatr Allergy Immunol 2001 Dec;12(6):312-7
Meijer RJ, Postma DS, Kauffman HF, Arends LR, Koeter GH, Kerstjens HA. Accuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthma. Clin Exp Allergy 2002 Jul;32(7):1096-103
Pizzichini E, Pizzichini MMM, Efthimiadis A, Dolovich J, Hargreave FE. Measuring airway infl ammation in asthma: Eosinophils and eosinophilic cationic protein in induced sputum compared with peripheral blood. J Allergy Clin Immunol 1997;99:539-544.
Lonnkvist K, Hellman C, Lundahl J, Hallden G, Hedlin G. Eosinophil markers in blood, serum, and urine for monitoring the clinical course in childhood asthma: impact of budesonide treatment and withdrawal. J Allergy Clin Immunol 2001 May;107(5):812-7
Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, Wardlaw AJ, Pavord ID. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002 Nov 30;360(9347):1715-21
Jang AS, Choi IS, Koh YI, Jeong TK, Lee KY, Kim YS, Lee JU, Park CS. Effects of prednisolone on eosinophils, IL-5, eosinophil cationic protein, EG2+ eosinophils, and nitric oxide metabolites in the sputum of patients with exacerbated asthma. J Korean Med Sci 2000 Oct;15(5):521-8
Grutters JC, Brinkman L, Aslander MM, van den Bosch JM, Koenderman L, Lammers JW. Asthma therapy modulates priming-associated blood eosinophil responsiveness in allergic asthmatics. Eur Respir J 1999 Oct;14(4):915-22
Rais M, Wild JS, Choudhury BK, Alam R, Stafford S, Dharajiya N, Sur S. Interleukin-12 inhibits eosinophil differentiation from bone marrow stem cells in an interferon-gamma-dependent manner in a mouse model of asthma. Clin Exp Allergy 2002 Apr;32(4):627-32
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.