FREQUENCY OF GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY AND RELATED HEMOLYTIC ANEMIA IN RIYADH, SAUDI ARABIA
AbstractBackground: Glucose 6 Phosphate dehydrogenase deficiency is present in over 400 million people world wide. It is more common iin tropical and subtropical countries and is one of the important causes of hemolytic anemia and neonatal jaundice. We studied the frequency of glucose-6-phosphate dehydrogenase deficiency and associated complications in Central Region (Riyadh) of Saudi Arabia. Methods: A total of 1740 subjects referred by Ministry of Interior and different hospitals in Riyadh were investigated for glucose-6-phosphate dehydrogenase deficiency. Glucose 6 phosphate dehydrogenase activity was determined by a screening test described by Beutler. Results: Out of these, 106 (6.09%) subjects were deficient. The subjects were divided into marriage and hospital groups. In marriage group deficiency was 4.1% while in hospital group it was 13.3%. In 54 glucose-6-phosphate dehydrogenase deficient patients red blood cell count and haemoglobin levels were determined to see the degree of anaemia. Sixty one percent (61%) had anaemia. In hospital patients 8% patients had severe anaemia while in marriage group no patients had severe anaemia. However mild anaemia was seen in 25% subjects in marriage group. Conclusions: In conclusion the study indicates that glucose-6-phosphate dehydrogenase deficiency is common in the central region of Saudi Arabia and a lot of patients present with haemolytic episodes. The haemolytic crisis however is not related to the intake of fava beans. The type of variant causing anaemia and suggestions for prevention in marriage group are outlined.Key words: glucose-6-phosphate dehydrogenase, deficiency, anaemia, marriage
Metha A, Manson PJ, Vulliamy TJ. Glucose-6-phosphate dehydrogenase deficiency. Baillieres Best Pract Res Clin Haematol 2000; 13(1): 21-38.
Mitchell BE. G6PD deficiency screening test. Blood 1968;32:816.
Zarza R, Pujades A, Rovira A, Aymerisy M. Two new mutations of the glucose-6-phosphate dehydrogenase gene associated with hemolytic anemia. Br J Haematol 1997; 98(3): 578-82.
Al-Ali AK. Common glucose-6-phosphate dehydrogenase variants from Saudi population and its prevalence. Annals Saudi Med 1996; 16(6): 654-57.
Joshi SR, Patel RZ, Patel MR, Sukumar S, Colah RB. High prevalence of glucose-6-phosphate dehydrogenase deficiency in Vataliya Prajapati Community in Western India. Haematologia 2001; 31(1):57-60.
Sanpavat S, Nuchprayoon I, Ungbumnet W. The value of methemoglogin reduction test for neonatal glucose-6-phosphate dehydrogenase deficiency. J Med Assoc Thai 2001; 84(1): 91-98.
Pietrepertosa A, Palma A, Delios G, Tannoia N. Genotype and Phenotype correlation in glucose-6-phosphate dehydrogenase deficiency. Haematologica 2001; 86(1):30-35.
Yahya HI, Al- Alawi NA. Acute haemolytic episodes and Fava bean consumption in glucose-6-phosphate dehydrogenase deficient Iraqis. Indian J Med Res 1993; 98: 290-292.
Warsy AS, El-Hamzi MA.F. Glucose-6-phosphate dehydrogenase deficiency. Distribution and variants in Saudi Arabia: An Overview. Annal Saudi Med 2001;21(3-4): 1-7
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.