• Rukhshan Khurshid
  • Mubbashir A Sheikh
  • Sabiha Karim
  • Farida Munnawar
  • Humairah Wyne


Background: There is increasing concern regarding antimicrobial resistance in Pakistan. Data are limited on the prevalence, pattern of resistance and risk factors associated with resistant organisms. This Study was done to address these issues as they relate to common infection of male/female. Methods: Different clinical materials collected from 100 patients admitted in hospital or who attended out door clinic were used.  Antibiotics like Enoxabid, Fortum, Ceporex, Klaricid, Maxaquin, Zenacef, Ceporexin, Urixin, Septran, Keflex, Erythrocine, vibramycin and tetracycline were used for culture sensitivity. Results: It was observed that most of the pus specimens received are from females and urine specimens from males.  Specimen of pus contains mostly Staph aureus, Urine specimen contain mostly E.coli whereas Pseudomonas pyrogenosa and proteases were also observed in urine, pus, sputum and ascitic/pleural fluids of patients. Among all drugs that were used, Enoxabid, Ceporex were vary sensitive against strains of Staph and Pseudomonas present in specimen. Strains of proteases were resistant against these drugs. Urixin and Septran show mixed action. In comparison of Enoxabid, Ceporex and Ceporexin, Zenocef and Fortum show sensitivity in fewer cases of Staph and E.coli.  Mexaquin shows a good sensitivity against Pseudomonas and E.coli. It was observed that Septran, Erythrocine, Vibramycin, Tetracyclin, Klaracid and Keflex are not very good acting drugs in infection of urine, pus, sputum and fluids. Finding of a low but definite level of resistance to septran, erythrocine, Vibramycin, Tetracyclin, Klaracid and Keflex is important for selection of empiric therapy for infection.


Katzung BG. Basic and clinical pharmacology. 6th ed Prentice Hall Int. Inc. London, 1995, 680-697

Isselbacher EH, Adams RD, Braunwald E, Petersdrof RG, Wilsod JD. Principles of Internal Medicine 14ed Mcgraw Int Book Co Ltd. London. 1994, pp198

Grent E, Abott A, Harris R. Continuos infusion of ß lactamase antibiotic. Conn Med. 1999, 63:275-280

Bauer JD. Clinical Laboratory Methods. 9th ed. CV Mosby Co. St Louis. 1982

Vogal Pl, Kemtebedde J, Hirsh DC, Kass PH. Wound contamination and antimicrobial susceptibility of bacterial culture dorsal ear canal ablation and latent osteotomy in dogs. J Am Vet Med Assoc. 1999,63:1641-3

Stephenson JM. Screening for genital chlamydial infection. Br Med Bull 1998, 54:891-902

Riedal CR, Plas E, Hubner WA. Zimmerl H, Ulrich W, Pfluger H. Bacterial colonization of ureteral stent. Em Urol 1999, 36:53-59

Recht MI, Douthwaite S, Puglis JD. Basis for prokaryotic specificity of action of aminoglycosides antibiotics. EMBO J. 1999, 18:3133-3138

Pichichero ME, Marsocci SM, Murphey Ml, Hoeger W, Green JL, Sorrento AK. Incidence of streptococcal carrier in private practice. Arch Pediatr Adolesc Med 1999, 153:624-628

Allen UD, Mac Donald N, Fuite L, Chen F, Stephen D. Risk factors for resistance to first line antimicrobial among urinary isolates of E.coli in children. CMAJ 1999,160:1436-40

Burnett GW, Scherp HW, Schuster GS. Oral Microbiology and Infectious disease. 4th ed Williams and Wilkins Co, Baltimore. 1986, pp197-202

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