SENSITIVITY AND RESISTANCE OF ANTIBIOTICS IN COMMON INFECTION OF MALE AND FEMALE
AbstractBackground: There is increasing concern regarding antimicrobial resistance in Pakistan. Data are limited on the prevalence, pattern of resistance and risk factors associated with resistant organisms. This Study was done to address these issues as they relate to common infection of male/female. Methods: Different clinical materials collected from 100 patients admitted in hospital or who attended out door clinic were used. Antibiotics like Enoxabid, Fortum, Ceporex, Klaricid, Maxaquin, Zenacef, Ceporexin, Urixin, Septran, Keflex, Erythrocine, vibramycin and tetracycline were used for culture sensitivity. Results: It was observed that most of the pus specimens received are from females and urine specimens from males. Specimen of pus contains mostly Staph aureus, Urine specimen contain mostly E.coli whereas Pseudomonas pyrogenosa and proteases were also observed in urine, pus, sputum and ascitic/pleural fluids of patients. Among all drugs that were used, Enoxabid, Ceporex were vary sensitive against strains of Staph and Pseudomonas present in specimen. Strains of proteases were resistant against these drugs. Urixin and Septran show mixed action. In comparison of Enoxabid, Ceporex and Ceporexin, Zenocef and Fortum show sensitivity in fewer cases of Staph and E.coli. Mexaquin shows a good sensitivity against Pseudomonas and E.coli. It was observed that Septran, Erythrocine, Vibramycin, Tetracyclin, Klaracid and Keflex are not very good acting drugs in infection of urine, pus, sputum and fluids. Finding of a low but definite level of resistance to septran, erythrocine, Vibramycin, Tetracyclin, Klaracid and Keflex is important for selection of empiric therapy for infection.
Katzung BG. Basic and clinical pharmacology. 6th ed Prentice Hall Int. Inc. London, 1995, 680-697
Isselbacher EH, Adams RD, Braunwald E, Petersdrof RG, Wilsod JD. Principles of Internal Medicine 14ed Mcgraw Int Book Co Ltd. London. 1994, pp198
Grent E, Abott A, Harris R. Continuos infusion of ß lactamase antibiotic. Conn Med. 1999, 63:275-280
Bauer JD. Clinical Laboratory Methods. 9th ed. CV Mosby Co. St Louis. 1982
Vogal Pl, Kemtebedde J, Hirsh DC, Kass PH. Wound contamination and antimicrobial susceptibility of bacterial culture dorsal ear canal ablation and latent osteotomy in dogs. J Am Vet Med Assoc. 1999,63:1641-3
Stephenson JM. Screening for genital chlamydial infection. Br Med Bull 1998, 54:891-902
Riedal CR, Plas E, Hubner WA. Zimmerl H, Ulrich W, Pfluger H. Bacterial colonization of ureteral stent. Em Urol 1999, 36:53-59
Recht MI, Douthwaite S, Puglis JD. Basis for prokaryotic specificity of action of aminoglycosides antibiotics. EMBO J. 1999, 18:3133-3138
Pichichero ME, Marsocci SM, Murphey Ml, Hoeger W, Green JL, Sorrento AK. Incidence of streptococcal carrier in private practice. Arch Pediatr Adolesc Med 1999, 153:624-628
Allen UD, Mac Donald N, Fuite L, Chen F, Stephen D. Risk factors for resistance to first line antimicrobial among urinary isolates of E.coli in children. CMAJ 1999,160:1436-40
Burnett GW, Scherp HW, Schuster GS. Oral Microbiology and Infectious disease. 4th ed Williams and Wilkins Co, Baltimore. 1986, pp197-202
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.