EFFECT OF MENOPAUSE ON SERUM HDL-CHOLESTEROL LEVEL

Authors

  • Norin Sultan
  • Muhammad Nawaz
  • Ambreen Sultan
  • Muhammad Fayaz
  • Abdul Baseer

Abstract

Background: There is a marked difference in the risk of coronary heart disease between men and women of reproductive age but this gap closes with advancing age. It seems likely that some factors of reproductive physiology are responsible for this. The present study was designed to evaluate the difference in HDL Cholesterol level in premenopausal and postmenopausal women in relation with change of estradiol level. Methods: Fifty premenopausal and 50 postmenopausal women were included in the study. Estradiol was estimated by radioimmuoassay while HDL-C was estimated by Kit method. Results: There was a significant (p<0.01) decrease in the HDL-C level of the postmenopausal women (46.72±1.009) as compared with premenopausal women (63.68±1.78). Conclusion: HDL-C is an independent risk factor for coronary heart disease. This study favours the view that decrease in estradiol level and associated decrease in HDL-C seen in postmenopausal women may be responsible for the increased risk of coronary heart disease after menopause.Keywords: Menopause; HDL-Cholesterol; Risk factor; Coronary Heart Disease

References

Arca M, Vega GL, Grundy SM. Hypercholestrolemia in postmenopausal women. JAMA 1994;27:453-9.

Kannel WB. Metabolic risk factors for coronary heart disease in women: Perspective from the Framingham study. Am Heart J 1987;114:413-9.

Connor EB, Busch TL. Estrogen and coronary heart disease in women. JAMA 1991;24:265:1861-7.

Tindall VR. Clinical aspects of ovulation and menstruation, In: Jeffcoat’s Principles of Gynaecology, 5th ed., Butterworth and Co. (Publishers) Ltd. London 1987 pp 88-93.

Khan RL. Puberty, menstruation and menopause, In: Gynaecology, 2nd ed., Medical Publications, Lahore, 1992, pp 38-41.

Connor EB. Oestrogen and oestrogen progesterone replacement therapy and cardiovascular diseases. Am J Med 1993;95(suppl.5A):405-35.

Tikannen MJ, Nikkila EA, Kuvsi T, Spinen S. High density lipoprotein-2 and hepatic lipase: Reciprocal changes produced by oestrogen and norgesterol. J Clin Endocrinol Metab 1982;54:1113-7.

Camm AJ. Cardiovascular disease, In: Clinical medicine, 2nd ed., Kumar, PJ and Clark, ML (eds.) Bailliers Tindall, London, 1990, pp 570.

Castelli WP. Cardiovascular diseases in women. Am J Obstet Gynecol 1988;158:1553-60.

Godsland IF, Wynn V, Crook D, Miller NE. Sex plasma proteins and outstanding questions. Am Heart J 1987;114:1467-503.

Castelli WP, Doyle JT, Gordon T, Hames CG, Hjortland MC, Hulley SB et al. HDL cholesterol and other lipids in coronary heart disease. Circulation 1977;55:767-72.

Miller GJ Miller NE. Plasma high density lipoprotein concentration and development of ischemic heart disease. Lancet 1975;(i):16-9.

Jacobs D, Blackburn H, Higgins M., Reed D, Iso H, Micmillan G et al. Report of the conference on low blood cholesterol. Mortality associations. Circulation 1992;86:1046-60.

England PC, Skinner LG, Cottrell KM, Sellwood RA. Serum oestradiol 17B in normal women. Br J Cancer 1974;29:462-9.

Shibata H, Haga H, Sayama Y, Kumagai S, Seino T. Serum total and HDL Cholesterol according to reproductive status in Japanese females. J Chron Dis 1987;40:209-13.

Razay G, Heaton KW, Bolton CH. Coronary heart disease risk factors in relation to the menopause. Quarterly J Med 1992;889-96.

Hong MK, Romm PA, Reagan K, Green CE, Rackley CE. Effects of oestrogen replacement therapy on serum lipid values and angiographically defined coronary artery disease in postmenopausal women. Am J Cardiol 1992;69:176-8.

Tadmor OP, Kleinman Y, Reisin A, Livshin Y, diamante YZ. The effects of two fixed hormonal replacement therapy protocols on blood lipid profile. Eruop J Obstet Gynecol Reprod Biol 1992;46:109-16.

Newnham HH. Oestrogens and atherosclerotic vascular disease-lipid factors. Bailleres Clin Endocrinol Metab 1993;7:61-93.

Whitley RJ, Meikle AW, Watts NB. Endocrinology, In: Tietz Textbook of clinical chemistry, 2nd ed., Burtis, CA and Ashwood, ER. (eds) W.B. Saunders Company, Philadelphia, 1994; pp 1876.

Richter V, Rassoul F, Opitz F, Purschwitz K, Rotzch W. Age related changes in lipid metabolism parameters: screening studies on population basis. Z Gerontol 1993;26:260-4.

Kannel WB. High density lipoproteins: epidemiologic profile and risks of coronary artery disease. Am J Cardiol 983;52:9B-12B.

Larosa JC. Lipids and cardiovascular disease: do the findings and therapy apply equally to men and women? Women’s Health Issues 1992;2:102-11.

Brunner D, Weisbort J, Meshulam N, Schwartz S, Gross J, Rennert H et al. Relation of serum total cholesterol and high density lipoprotein cholesterol percentage to the incidence of definite coronary events: Twenty year follow up of the Dono-Tel Aviv prospective coronary artery disease study. Am J Cardiol 1987;59:1271-6.

Downloads

Most read articles by the same author(s)

<< < 1 2