• Rustam Khan
  • Shahab Abid
  • Saeed Hamid
  • Zaigham Abbas
  • Hasnain Shah
  • Wasim Jafri


Background: This study was carried out to evaluate and compare the outcome of various causesof non-malignant lesions of the esophagus after endoscopic therapeutic intervention. Methods: Acohort of patients with non-malignant dysphagia presenting at Aga Khan University hospital, atertiary care setting who underwent endoscopic intervention was studied. Response to treatmentwas evaluated by improvement in dysphagia score on a scale of 0-4 and weight gain. Results: 99subjects (53 males) were included. Mean age was 48.6±17.2 years. Dysphagia for solids waspresent in 48%, for liquids in 3% and for both in 49% patients. Significant weight loss (>10%body weight) occurred in 35 (35.3%) patients. Achalasia was diagnosed in 49.5%, peptic stricturein 30.4%, post sclerotherapy stricture in 12.1%, corrosive injury in 4%, post-operative stricture in4%. In comparative analysis of achalasia and inflammatory groups, good response to dysphagiawas seen in 40/49 (82%) and 22/50 (44%) respectively p < 0.001. Weight gain was 35/49 (72%)and 22/50 (44%) p <0.001 respectively. Significantly, more endoscopic sessions were required ininflammatory group compare to achalasia; 2.2 and 1.1 respectively; p <0.001 and 16%complications rate in inflammatory group comparing to no complications in achalasia.Conclusions: Dysphagia and weight loss were common presentations in non-malignantesophageal diseases. Therapeutic intervention in inflammatory group was associated with highcomplication than the achalasia group.Key words: outcome of non-malignant esophageal diseases, Benign esophageal lesions,Achalasia, esophageal strictures.


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