ASSOCIATION BETWEEN WHITE BLOOD CELL COUNT AND LEVELS OF SERUM HOMOCYSTEINE IN END-STAGE RENAL FAILURE PATIENTS TREATING WITH HEMODIALYSIS

Authors

  • Azar Bradran
  • Hamid Nasri

Abstract

Background: In hemodialysis patients, plasma levels of total homocysteine are influenced bynutritional status in patients with chronic kidney disease .To investigate the association betweenserum homocysteine (Hcy) level as a marker of nutritional status and WBC counts as a marker ofinflammation, a cross-sectional study was conducted on patients with end-stage renal disease(ESRD), who were undergoing maintenance hemodialysis treatment. Methods: Serumhomocysteine (total) and WBC count were measured. Other biochemical analysis including serumpredialysis creatinine (Creat), post and predialysis blood urea nitrogen (BUN), albumin (Alb),serum C-reactive protein (CRP) and serum ferritin were measured, also intact serum PTH (iPTH)and plasma HCO3 was measured too. For the efficacy of hemodialysis the urea reduction rate(URR) was calculated from pre- and post-blood urea nitrogen (BUN) data. The body mass index(BMI) was also calculated. For correlations the partial correlation test was used. Results: Totalpatients were 36(f=15 m=21), consisting of 25non-diabetic HD patients and 11diabetic HDpatients. The mean patient's age was 47±17years. In all patients a significant inverse correlationof serum homocysteine with WBC count and a significant positive correlation of serumHomocysteine with BMI and a near significant positive correlation of WBC count with serumCRP were found. Conclusion: In hemodialysis patients an inverse correlation between WBCcount as a marker of inflammation with serum Hcy level as a marker of nutritional status, furthersupport the hypothesis of the malnutrition-inflammation cachexia syndromeKeywords: White blood cell, Serum homocysteine

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