• Rubab Ahmed
  • Faisal Sultan


Background: Tuberculosis of breast is a rare entity and may be confused with carcinoma of thebreast. We present a case series of 14 patients with granulomatous mastitis, seen over a seven-yearperiod from a cancer centre in Lahore, Pakistan. Methods: The cases were retrieved usingelectronically coded records and clinical, radiological and pathological data reviewed. Cases witha histologic diagnosis of granulomatous mastitis were included. Results: Granulomatous mastitiswas seen at a frequency of 0.37% of the 3768 patients seen with breast diseases (3722 women; 46men) during this time period. The average age at presentation was 40.7 years [range 14- 65 years].The most common presentation was a lump in the upper outer quadrant of the breast.Mammography showed a range of appearances. Diagnosis was obtained via fine needle aspiration(10 cases), core biopsy (2 cases) and excision (2 cases). Acid-fast bacilli were seen in five out ofthe 14 patients. Ten out of 14 patients completed treatment at our centre with satisfactoryresponse. Conclusions: Granulomatous mastits is an uncommon disease and typically presentswith a lump in the breast. The diagnosis can be established by fine needle cytology in the majorityof cases. Acid-fast bacilli are seen a minority of the cases.Key words: granulomatous inflammation, mastitis, breast, tuberculosis, Pakistan.


Khanna R, Prasanna GV, Gupta P, Kumar M, Khanna S,

Khanna AK. Mammary Tuberculosis: Report on 52 Cases.

Postgrad Med J. 2002; 78: 422-424.

Kalac N, Ozkan B, Bayiz H, Dursun AB, Demirag F. Breast

Tuberculosis. Breast. 2002; 11(4): 346-9.

Makanjuola D, Murshid K, Al Sulaimani S, Al Saleh M.

Mammographic features of breast tuberculosis: the skin bulge

and sinus tract sign. Clin Radiology 1996; 51(5): 354-8.

Lim ET, O’ Doherty A, Hill AD, Quinn CM. Pathological

axillary lymph nodes detected at mammographic screening.

Clin Radiol.2004; 59: 86-91.

Popli MB. Pictorial Essay: Tuberculosis of the breast. Ind J

Radiol imag 1999; 9: 3: 127-132.

Bedi US, Bedi RS. Bilateral breast tuberculosis. The Indian

Journal of Tuberculosis 2001; 48(4): 215-7.

Sakr AA, Fawzy RK, Fadaly G, Baky MA. Mammographic

and sonographic features of tuberculous mastitis. European

Journal of Radiology 2004; 51: 54-60.

Morsad F, Ghazali M, Boumzagou K, Abbassi H, El

Kerroumi M, Mata Belabidia B et al. Mammary tuberculosis:

a series of 14 cases. J Gynaecol Obster Biol Reprod 2001;

(4): 331-7.

Crowe DJ, Helvie MA, Wilson TE. Breast infection.

Mammographic and sonographic findings and clinical

correlation. Invest Radio 1995; 30 (10): 582-7.

Makanjuola D, Murshi K, Al Sulaimani S, Al Saleh M.

Mammographic features of breast tuberculosis: the skin bulge

and sinus tract sign. Clin Radiol 1996; 51(5): 354-8.

Kakkar S, Kapila K, Singh MK, Verma K. Tuberculosis of

the breast. A cytomorphologic study. Acta Cytol 2000; 44:


Tse GMK, Poon CS, Law BKB, Pang LM, Chu WCW, Ma

TKF. Fine needle aspiration Cytology of granulomatous

Mastitis. J Clin Pathol 2003; 56: 519-521.

Pandey M, Abraham EK, Rajan B. Tuberculosis and

metastatic carcinoma coexistence in axillary lymph node: a

case report. World J Surg Oncol 2003; 1(1): 3.