HISTOLOGICAL CHANGES IN PARTS OF FOREGUT OF RAT AFTER INDOMETHACIN ADMINISTRATION
AbstractBackground: Indomethacin, a non-steriodalanti-inflammatory drug, is used mainly for thetreatment of painful joints such as rehumatoid arthritis, osteo–arhtritis, gout, ankylosingspondylitis etc. It relieves pain, reduces swelling and tenderness of the joints. It also inducesulceration of stomach and small intestine both in experimental animals and humans. Material andMethods: In this study indomethacin was given intrapertioneally in maximum therapeutic dose (4mg/Kg body weight) to three experimental groups B, C and D for one, two and three weeksrespectively. Group A was the control group. Results: Effects were observed in stomach pylorusand proximal duodenum. In the stomach pylorus, well defined superficial ulcers were identifiedduring initial two weeks of drug administration. The ulcer penetrated as for as muscularis mucosaeand ulcer bed had coagulative necrosis and inflammatory cells. During third week, stomachpylorus showed minor damage in the form of focal necrosis. Duodenum was affected less thanstomach and showed villi with lost tips, tilted and distorted villi. Morphometric analysis showedchanges in stomach pylorus and in duodenum. The number of mitotic figure was significantlyincreased in stomach pylorus. Duodenum showed insignificant to significant decrease in the heightof villi. Increase in the number of goblet cells, columnar cells, and mitotic figure was also noted;which was undoubtedly part of the tissue response to an injury. Conclusion: These observationssuggested that indomethacin given in a ma ximum therapeutic dose, initially induces lesions instomach pylorus and proximal duodenum but almost no effects were noted when duration of thedrug administration was prolonged.Key Words: Indomethacin, Stomach, Duodenum.
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