LIVER DYSFUNCTION IN DENGUE INFECTION, AN ANALYSIS OF THE PREVIOUSLY PUBLISHED THAI CASES
AbstractBackground: Dengue infection is a major vector-borne disease. The classical sings and symptomsof this infection include high fever, violent headache, chill and rash. However, there are a numberof atypical forms of dengue infection including those presented with liver dysfunction. However,there are only a few reports concerning the liver dysfunction among the patients with dengueinfections. Methods: Here, the author presents a summative study on the liver dysfunction and itsclinical correlation among Thai patients in the previous studies. A literature review on theprospective studies concerning liver function and dengue infection in Thailand was performed.Results: According to this study, there are 4 reports included covering 191 Thai pediatric patientswith dengue infection. The overall rate of liver dysfunction among 191 subjects is 34.6 % (66/191).The rate of liver dysfunction among the patients without shock (36/120) is not significant differentfrom those with shock. The rate of liver dysfunction in this study is considerable high, similar tothe previous reports from other developing Asian countries. In addition, about 8 % (5/66) thepatients with liver dysfunction developed hepatic encephalopathy. Conclusions: This can implythe importance of detection of abnormal high transaminase enzyme among the patients withdengue infection since the consequently developed hepatic encephalopathy can be expected.Key words: Dengue, Liver, Dysfunction
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