INCIDENTALLY FOUND METASTATIC PROSTATIC CARCINOMA IN A THERAPEUTIC ORCHIECTOMY SPECIMEN

Authors

  • Muhammad Bilal Shifa International Hospital, Islamabad.
  • Zeeshan Uddin Aga Khan University Hospital, Karachi
  • Mohammad Ayaz Khan Shifa International Hospital, Islamabad

Abstract

ABSTRACT:  Metastatic tumor involving the testis is a rare event. Incidental discovery of metastatic cancer in a therapeutic orchiectomy is even rarer. We report a case of metastatic adenocarcinoma prostate found incidentally in one of the bilateral therapeutic orchiectomy specimen. The patient was a 55 year-old man presenting with back ache and generalized body aches. Clinical examination showed malignant feel of prostate. Bone scan revealed metastatic disease and a serum PSA level of >100 ng/ml. Clinical diagnosis of carcinoma prostate was established and subsequent bilateral orchiectomy for hormonal deprivation was performed. On gross examination of left testis, there was a small 0.7 X 0.6 cm suspicious area. Microscopically, this area showed an infiltrating tumor in the interstitium with entrapped seminiferous tubules. Focal intravascular tumor deposit was also noted. Immunohistochemical stain for prostate-specific antigen was positive in the tumor, which confirmed the diagnosis of metastatic prostate adenocarcinoma.  KEY WORDS:  metastasis, microscopy, orchiectomy, prostate cancer, testis.Metastatic tumour involving the testis is a rare event. Incidental discovery of metastatic cancer in a therapeutic orchiectomy is even rarer. We report a case of metastatic adenocarcinoma prostate found incidentally in one of the bilateral therapeutic orchiectomy specimens. The patient was a 55-year-old man presenting with back ache and generalized body aches. Clinical examination showed malignant feel of prostate. Bone scan revealed metastatic disease and a serum PSA level of >100 ng/ml. Clinical diagnosis of carcinoma prostate was established and subsequent bilateral orchiectomy for hormonal deprivation was performed. On gross examination of left testis, there was a small 0.7 X 0.6 cm suspicious area. Microscopically, this area showed an infiltrating tumour in the interstitium with entrapped seminiferous tubules. Focal intravascular tumour deposit was also noted. Immunohistochemical stain for prostate-specific antigen was positive in the tumour, which confirmed the diagnosis of metastatic prostate adenocarcinoma.Keywords: Metastasis; Microscopy; Orchiectomy; Prostate Cancer; Testis

Author Biographies

Muhammad Bilal, Shifa International Hospital, Islamabad.

Histopathology department, Postgraduate resident.

Zeeshan Uddin, Aga Khan University Hospital, Karachi

Consultant Histopathology

Mohammad Ayaz Khan, Shifa International Hospital, Islamabad

Consultant Urology

References

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Published

2018-12-09