POSTPRANDIAL VARIATIONS IN BLOOD PRESSURE IN THE ELDERLY PEOPLE
AbstractABSTRACTAgeing is associated with changes and deterioration in functions and structure of manysystems including cardiovascular system. Besides other changes the activity of baroreceptors andautonomic system, both of which are important for the homeostasis of blood pressure under differentphysiological conditions in daily life, is said to be reduced with the advancing age. Food intake isone of the important factors, which influence the cardiovascular system, and readjustments takeplace in the system for blood pressure homeostasis after ingestion of meal. The present study wasplanned to evaluate and compare the postprandial changes in blood pressure in young adults andelderly people. A total of 70 male healthy individuals (50 elderly & 20 young adults) were selectedfor the study. Blood pressure and pulse rate were measured before a standard breakfast and then atintervals of 15 minutes each, after meal, for one hour. In the young adults group, the systolic,diastolic and mean arterial pressure showed no significant change after meal while pulse pressurewas raised for first 30 minutes after meal, returning again to almost pre-prandial level in next 30minutes. The pulse rate was however increased significantly after meal. In the elderly subjects, onthe other hand, there was moderate to marked decline in systolic, diastolic, mean arterial and pulsepressures without any increase in the pulse rate. This response to meal in the elderly subjects wasfound to be significantly different from that in the young adults.
Silverstein, M.D., Singer. D.E , Mulley, A.G., Thibault, G.E. and Barnett, G.O. Patients with syncope admitted
to medical intensive care units. JAMA.,1982, 248: 1185-1189.
Kohn.R.R. Cause of death in very old people. JAMA., 1982;247:2793-2797
Finch,C.E. and Havflick L. Handbook of biology of aging. New Yark. Van Nostrand Reinhold Co., 1977, pp
. Julius,S.Amery, A., Whitlock, L.S. and Conway,J. Influence of age on hemodynamic response to exercise.
Circulation, 1967; 34: 222-230
Learoyd, B.M. and Taylor VI.G. Alteration with age in the viscoelastic properties of human arterial wall.
Cir.Rcs.,1966: 18: 278-292
Sundlof, G. and Wallin, B.G. Human muscle nerve sympathetic activity at rest.Relationship to blood pressure
and age. J.Physiol., 1978; 274: 621-637
Gribbin, B.. Pickering, T.G., Sleight, P and Peto,R. Effect of age and high blood pressure on baroreflex activity
in man. Cir Res., 1971; 29: 424-31
Muratori,G Histological observation on the structure of the carotid sinus in man and mammals. In
Baroreceptors and hypertension, Kezdi. P., Oxford:Pegman, 1967, pp., 253-265 9
Abraham,A. The structure of baroreceptors in pathological conditions in man. In: Baroreceptors and
hypertension, Kezdi, P , Oxford: Pegman, 1967, pp.,273-291
Robertson, D. Wade, D and Robertson, R.M. Postprandial alteration in cardiovascular hemodynamics in
autonomic dysfunctional states. Am..! Cardiol . 1981; 48: 1048-1052
Brandt, J.L., Castleman, L . Ruskin, H D. Greenwald, J and Kelly Jr., J.J. The effect of oral protein and glucose
feeding on splanchnic blood flow and oxygen utilization in norma! and cirrhotic subjects J. Clin Invest., 1955;
Bloom, S.R., Edwards.A.V., Hardy,R.N., Malinowska, K. and Silver.M. Cardiovascular and endocrine
responses to feeding in young calf J.Physiol., 1975; 253: 135-155
Bannister, R , Christensen, N.J., Costa, D.F., Mathias, C.J. Wright, H. and Lois, J.U. Mechanism postprandial
hypotension in autonomic failure. J.Physiol., 1984;349: 67
Appenzeller, O. and Goss, J.E Glucose and baroreceptor function. -Arch. Neurol., 1970; 23: 137-146
American Heart Association. Recommendations for sphygmomanometery. Am. Heart. J., 1969; 77: 17- MS
Blair-West, J.R. and Brook,A H. Circulatory changes and renin secretion in sheep in response to feeding.
J.Physiol., 1969, 20:15-30
Guyton. A.C. Textbook of medical physiology,7th ed. Philadelphia,W.B. Saunders and Co., 1986,pp, 206-217
ManicaXL, Ferrari,A., Gregorini.L... Parati, G., Farrari, M.C., Pomidossi,G. and Zanchetti,A. Control of
blood pressure by carotid sinus baroreceptors in human beings. Am. J. Cardiol., 1979, 44: 895-902
Bader,H Dependence of wall stress in the human thoracic aorta on age and pressure Cir Res., 1967; 20: 3544-
Vatner,S.F., Franklin,D and Citters.R.L. V Mesenteric vasoactivity associated with eating and digestion in the
conscious dog Am.J.Physiol., 1970; 219: 170-174
Johnson, R.H., Smith. A.C..Spalding, J.M.K. and Wollner, L. Effects of posture on blood pressure in elderly
patients Lancet. 1965; 3: 731-733
Page.M.M B. and Watkin, P.J. Provocation of postural hypotension by insulin in diabetic autonomic
neuropathy. Diabetes, 1976, 25: 90-95
Rowe, J.W., Young, J.B., Minaker,K.L., Stevens,A.L„ Pallotta,J and Landsberg, L. Effect of insulin and
glucose infusions on sympathetic nervous system activity in normal man. Diabetes, 1981; 30: 219-225
Bannister, R.,Costa, D.F.,Fosbraey,P. and Mathias, C.J. Exogenous insulin lowers blood pressure in autonomic
failure. J Physiol , 1985; 364: 132
Bannister, R.,Costa, D.F.,K.ooner,J.s., MecdonaldJ.A and Mathias, CJ. Insulin induced hypotension in
autonomic failure during euglycemia in man. J.Physiol., 1987; 382:36
Minaker, K.I., RoweJ.W., Young,J.X., Sparrow,D., Pallotta, J.A. and Landsberg,L.Effcct of age on insulin
stimulation of sympathetic nervous system activity in man. Metabolism, 1982; 31: 181-184s
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