COMPARATIVE GASTRIC ULCEROGENIC EFFECTS OF NAPROXIN, FENOPROFEN AND RECTIFIED SPIRIT IN ALBINO RAT
AbstractABSTRACT:A study of comparative ulcerogenicity of naproxen, fenoprofen and rectified spirit was conducted underdissecting as well as laboratory microscope. Different parameters of mucus barrier disruption werestudied in detail and a statistical comparison was made between the three drugs used. It was found thatunder dissecting microscope the difference was non-significant but under light microscope naproxen wasmaximally ulcerogenic followed by rectified spirit and fenoprofen was least ulcerogenic.
Held, WI, Goldbloom, A.A. Peotic ulcer its diagnosis and treatment. 1st edition. Springfield, Charles C.
Thomas Publishers, 1961, pp3
Reynold, JEF, Martindale. The extra-Pharmacopoeia. 28 ed. London Pharmaceutical press, I982.pp 253-
British Pharmacopoeia. Vol. l, London her Majesy’s Stationary office. 1980, pp 561.
Crosland J. Lewis’s Pharmacology^' ed. London Churchill Livingstone, 1980 pp 561.
Diamentis W. Melton J, Sofia RD, Colfalo, VB, Comparative gastric ulcerogenic effects of mescelazone
-chlorosalicytic acid and other non-steroidal anti-inflammatory drugs following acute and repeated oral
administration to rat. toxicol.App. Pharmacol. 1980; 52:454-461.
VanKolfschoten A.A, Zandberg Vice-Principal, Jagar IP and Noordwijkc JV, Protection by paracetamol
against various gastric irritants in the rat. Toxicol.Appl. Pharmacol. 1983; 69:37-42
Bonta LI A study of effect of some glucocorticoids and ACTH on artificially undued gastric ulcer of the
rat. Arch. Int. Pharmacodyn. 1961; 132:142-163.
Orlicz S Ci, Gabka M Use of prostaglandin inhibitor, 2-(6-methoxy 2 napthoyle) propionic acid, with
regard to morphological and enzymatic changes of gastric mucosa. Z. Mickrosk. Anat. Forsch. 1990;
Fung WP, Papadimitriou JM, Metz L. Effect of acetylsalicylic acid, indomathacin. phenylbutazone,
paracetamol. Ibuprofen and Naproxen on canine gastric mucosa. Ann.Acad. Med.Singapore. 1981.
Fujii A, Kubeyama N, Kobagash S, Namiki Y, Tamura T. Time coverage study of gastric damage in rat
by anti-inflammatory drugs using a gastroscope and its quantification. Jpn. J. Pharmacol. 1988