• Mukhtar Ahmad Wahid
  • George Kuruppacheril Abraham


ABSTRACTHuman sera comprising 545 specimens spread over a period of three years were analyzedelectrophorctically for proteins. Only 159 samples (29%) exhibited abnormal serum proteinpatterns. They were in the order of inflammatory disorders (acute/chronic), 60 (37.7%), Polyclonalgammopathies,48 (30.1%), Cirrhosis, 22 (13.8%), Monoclonal gammopathies, 22 (13.8%),Agammaglobulinemia, 3 (1.9%), Nephrosis, 2 (1.2%), Protein-losing enteropathy, 1 (0.6%), Lowalpha 1 —antitrypsin, 1 (0.6%), Inflammatory diseases of various nature, therefore, constitute themajor serum protein abnormalities in Riyadh. Moreover, their occurrence varies with age, sex andclimatic conditions as elsewhere in the world.


Putnam F.W. The Plasma Proteins. Academic Press. New York, 1975 Vol. 1, 2nd edn.

Putnam F.W. Immunoglobulins. In. Putnam F.W. The Plasma Proteins. Academic Press New York 1975

Vol. 3.

Pruzanskiw, Keystone E.C. Paraproteins in Disease Investigation of Plasma Cell Dyscrasia, 1985, 195.

Electrophoresis Reference Chart, Helena laboratories. Beaumont, Taxes, U.S.A.

Krieg A.F. Serum Protein Electrophoresis: Clinicopathologic Correlation. In Davidson I., Henry J.B.,

Todd — Sanford: Clinical Diagnosis by Laboratory Methods, W.B. Saunders and Co. Philadelphia. 1986,

th edn.

Lawrence J.S. Rheumatism in Population. Neinemann, London, 1977.

Ritzmann S.e., Daniels J.C. Serum Protein Abnormalities Diagnostic and Clinical Aspects. Little Brown,

and Clinical Aspects. Little Brown and Co. Beston. 1975.

Fries J.F., Mitchels D.M. Joint Pain or Arthritis. JAMA 1976, 235: 199.

Schreiber G: Synthesis, Processing and Secretion of Plasma Proteins by the Liver and their regulation. In

Puntnam F.W. The Plasma Proteins, Academic Press, New York, 1987 Vol. 5.

Houck J.C. Chemical Messengers of the inflammatory process. In Handbook of inflammation, Elsevier,

North Holland Press. Amsterdam. 1980 Vol. 1.

Schreiber G. Hewlett G., Nagashima M. et al. The acute phase response of plasma protein synthesising

during experimental inflammation. J. Biolt. Chem 1982; 257; 10271.

Faymonvill M.E. Micheels J., Bedson L., Jacquemin D., Lamy M. Adam A, Duchateam J. Minor bums

lead to major changes in synthesis rates of plasma proteins in the liver Bums, 1987; 13; 26.

Dickson P.W., Bannister D., Schciberg G. Acute phase response of the plasma proteins synthesising

system in the liver to the tissue damage, Trauma, 1987; 27; 283.

Cohen S., Martin N.H.: Thompson R.H.S., Wootton I.D.P. Biochemical Disorders in Human disease.

Academic Press New York, 1970; 535.

Davidson I., Henry J.B.; Todd Sanford: Clinical Diagnosis by Laboratory Methods W.D. Sannders and

Co. Philadelphia. 1986; 967.

Broitman S.A. Zamcheck N. Nutrition in Disease of the intestines: Protein-Losing Enteropathies. In Good

heart R.S., Shils M.E. Nutrition in Health and diseases. Lea Fibiger, Philadelphia, 1980 930.

Alpher C.A. Plasma protein measurements as diagnostic aid. New Engl. J. Md. 1974; 291; 287.

Davidson I., Henry J.B.; Todd Sanford: Clinical Diagnosis by Laboratory Methods W.d. Sannders and Co.

Philadelphia 1986; 208.

Schreiber G. Hewlett G.; Acute-phase Proteins. In Glaumann H., Peters T. JR., Redman C. Plasma Protein

Secretions by the Liver. Academic Press. London 1983. 423 - 449.