EFFECT OF ANTICONVULSANT DRUGS ON MONOVALENT CATIONS
AbstractABSTRACT:Sixty patients receiving anticonvulsant drugs like tegretol 9 Carbamazepine and 61 agematched controls were studied to determine the disturbances in sodium and potassium. levels Therewas a significant difference in sodium level the mean serum sodium levels of the subjects (138.8±0.6 mEq/L) and the controls (141.7± 0.4 mEq/L). Thirteen (21.7%) of the subjects, but none of thecontrols, had sodium levels 135 mEq/L. But the mean values of potassium (4.3 ± 0.02 mEq/L), werenot significantly changed as compared to controls. The risk of hyponatremia increased with age(subjects 30 years old had four limes the prevalence of hyponatremia as those < 30 years old.
Ashion, M.G., Ball, S.G., Thomas, T.H., Lee, MR. Water intoxication associated with carbamazepine
treatment. Br. Med. J. 1977; 1:1134-35.
Flagel, K.M., Cole C.H. Inappropriate antidiuresis during carbamazepine treatment. Ann Intern Med. 1982;
Rado, J.P. Water intoxication during tegretol treatment. Br. Vied. J. 1973; 3: 479.
Helin, I., Nilsson, K.O., Bjerre, I., Vegfors, P. Scrum sodium andosomlaity during tegretol treatment in
children. Br. Med. J. 1979; 2:558.
Henry, D.A., Lawson, D.IL, Reavey, P., Renfrew, S. Hyponatremia during tegretol treatment. Br. Med., J.
; 1: 83-84.
O'Hare, J., O'Driscoll, D., Duggan, B., Callaghan, . Hyponatremia and tegretol intoxication. Ir. J. Med.
Sci. 1988; 149-10-14.
Udhe, T.W., Post, R. V1. Effects of tegretol on scrum electrolytes; clinical and Theoretical Implications J.
Clin Faychopharmacol 1989; 3: 103-6.
Koivikko, M.J., Valikangas, S.I. Hyponatremia during Carbamazepine therapy in children. Neuropediatric
; 14: 93-96.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.