FLUID REGULATION AND ADH IN RAT OESTROUS: THE EFFECTS OF OESTRADIOL
Abstract
To determine how fluctuations in vasopressin are related to fluid ha la nee, studies were carried out in ovariectomized Sprague-Dawley rats injected daily with either vehicle or oestradiol benzoate (50, µg/rat) for 14 days. The animals were housed individually under 12 h light/12 h dark regimen with free access to food and water. Inputs & outputs were recorded and urine samples obtained to determine volume and osmolality. Plasma vasopressin levels were determined by radioimmunoassay. In the oestradiol benzoatetreated rats, food and water intakes were reduced during both dark and light periods compared with vehicletreated rats. Urine output showed a similar pattern of changes and appeared to be related to the vasopressin concentrations. Urine osmolality also correlated with the plasma vasopressin levels. These results indicate water retention in oestradiol benzoate-treated rats, and that oestradiol-induced increase in vasopressin may play a role in this fluid retention.References
Greene R and Dalton K. The premenstrual
syndrome. Br Med J, 1953; 1007-1014.
Akerlund M, Stromberg P and Forsling ML.
Primary Dysmenorrhoea and Vasopressin. Br J
Obstet and Gynaecol, 1979; 86: 484-87.
Forsling ML, Akerlund M and Stromberg P.
Variations in plasma concentrations of
vasopressin during the menstrual cycle. J
Endocrinal, 1981; 80: 263-66.
Forsling ML and Pevsner K. Diurnal variation in
plasma and pituitary- vasopressin in the rat. J
Physiol, 1984; 358: 104.
Khan MA, Aslam M and Babar MK. Fluid balance
in cycling and ovariectomized rats treated with
oestradiol benzoate. Pak Armed Forces Med J,
; 44(1): 7-14.
Butcher RL, Collins WE and Fugo NW. Plasma
concentrations of LH, FSH, Prolactin,
Progesterone and Oestradiol- 17p throughout the 4
day oestrus cycle of the rat. Endocrinal, 1974; 94:
-8.
Forsling ML. Stromberg P and Akerlund M.
Effects of ovarian steroids on vasopressin
secretion. Endocrine, 1982; 95: 147-51.
Wade GN. Sex hormones regulatory' behaviour
and body weight. Adv Stud of Behav, 1976; 6:
-79.
Sendi AA, Forsling ML, Khan MA and Peysner K.
Fluid balance over the oestrous cycle in the rat. Br
Neuroendocr Gr, 1985; p 35.
Downloads
How to Cite
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
