SUCCESSFUL TREATMENT OF CUTANEOUS LEISHMANIASIS WITH INTRALESIONAL GLUCANTIME
Abstract
We performed a clinical trial to evaluate the efficacy and safety of intralesional glucantime in cutaneous leishmaniasis. Thirteen patients with cutaneous leishmaniasis were treated with intralesional glucantime using a 23-gauge needle. Each lesion was infiltrated with 1-2 ml of solution without local anaesthesia. Total number of injections was from 3 to 5, each one week apart. Resolution of the lesions was obtained in most of the patients (9 out of 13). The location and duration of the lesion did affect the outcome of treatment. The treatment was generally well tolerated. Intralesional treatment of cutaneous leishmaniasis is safe, effective and cheap, and excellent cosmetics results may be achieved.References
Bryceson A. Therapy in man. In: Peles W &
Killickkendrick R (Eds). The leishmaniasis in
biology and medicine: Vol 2, Academic Press,
London, 1987; pp 848-907.
Neva FA, Petersen E, Corsey R, et al. Observation
on local heat treatment for cutaneous
leishmaniasis. Am J Trop Med Hyg, 1984; 33:
-4.
Bassiouny A, El Meshad M, Talaat M. Et al.
Cryosurgery in cutaneous leishmaniasis. Br J
Dermatol, 1982; 107: 467-74.
Currie MA. Treatment of cutaneous leishmaniasis
by curettage. Br Med J, 1983; 287:1053-6.
El-On J, Weinrauch L, Livshin R. et al. Topical
treatment of recurrent cutaneous leishmaniasis
with ointment containing paromomycin and
metlhylbenzalkonium chloride. Br Med J, 1985;
: 704-5.
W.H.O. The leishmaniasis. Report of W.H.O.
Expert Committee. Technical Report Series 701.
Geneva: World Health Organization, 1984.
Bryceson ADM. Diffuse cutaneous leishmaniasis:
treatment. Trans Roy Soc Trop Med Hyg, 1970;
: 369-79.
Bryceson ADM. Clinical variations associated
with various taxa of leishmania. Coll. Int.
CNRS/INSERM 1984. Montpelier. IMEEE,
; pp 221-8.
Lainsus R. The American Leishmaniases: Some
observations on their ecology and epidemiology.
Trans Roy Soc Trop Med Hyg, 1983; 77:579-96.
