ALTERATIONS IN PLASMA FIBRINOGEN DURING LIFE EVENTS IN WOMEN
AbstractChanges in plasma fibrinogen levels were observed in women during pregnancy, labour, postmenopause and after taking oral contraceptives. Mean fibrinogen level was highest at delivery, higher during pregnancy and high in postmenopausal women. Women who ceased menstruation with contraceptive drugs had lower values of plasma fibrinogen than control group.
Tietz NW. Text book of Clinical Chemistry. W B
Saunders Co, Philadelphia, London, 1986; 1747-49.
Hassan K, Shuaib A, Rana S, Firdous S & Mirza I.
Coagulation parameters in full-term normal pregnancy
during labour. RMJ, 1991; 19(3): 79-82.
Lahteenmaki P, Rasi V, Luukkainen T and Myllya G.
Coagulation factors in women using oral contraceptives
or IUCD immediately after abortion. Am J Obstet
Gynecol, 1981; 141: 175-79.
Meade TW, Haines AP & Imenson JD. Menopausal state
and haemostatic variables. Lancet, 1983; 34: 22-24.
Bahakim H, Galil AM, Gader A & Edress YB.
Coagulation parameters in maternal and cord blood at
delivery. Annals of Saudi Medicine. 1990; 10(2): 149-
Clauss A. Gerinnungs-physiologische schnell- methode
Zur Bestimmung des Fibrinogens. Acta Haematol, 1957;
Gillman T, Naidoo SS & Hathorn M. Plasma fibrinogen
activity in pregnancy. Lancet, 1959; 2: 70-71.
X. Stirling Y, Woolf L & North WRS. Haemostasis in
normal pregnancy. Thromb Haemost, 1984; 52: 176-82.
Regoeczi E& Hobbs KR. Fibrinogen turnover in
pregnancy. Scand J Haematol, 1969; 6: 175-78.
McDonald MM & Hathaway WE. Neonatal hemorrhage
and thrombosis. Semin Perinatol. 1983; 7: 213-25.
Lee AJ, Lowe GDO, Smith WCS and Pedoe, HT. Plasma
fibrinogen in women: relationships with oral
contraception, the menopause and hormonal
replacement therapy. Br J Haematology, 1993: 83: 616-