• Imranullah Khan
  • Muhammad Javed
  • Humayun Shah


We conducted a study on 27 patients (17 males, 10 females) to evaluate the efficacy of oral Terbinafine on a short term basis. All the patients had clinical and mycologically proven tinea cruris I corporis. Each patient was given 250 mg Terbinafine (Lamisil) after meals, once daily for one week. Patients were followed up for 6 weeks after completion of treatment. Patients were assessed clinically and mycologically at the end of treatment and the end of the follow up period. The signs and symptoms of the disease had almost disappeared at the end of the follow up period. Mycological investigations were negative in all patients at this time, except for one. As reported in other studies, our results show that one-week oral therapy with 250 mg/day of Terbinafine is effective and cheap for the treatment of tinea corporis/cruris


Farag A. One-week therapy with oral terbinafine in

cases of Tinea Cruris/Corporis. BJD, 1994, 131: 684-

Ryder NS. Specific inhibition of fungal sterol

biosynthesis by SF 86-327, a new allylamine

antimycotic agent. Antimic Agents Chemother, 1985;

: 252-56.

Ryder NS. The mechanism of action of terbinafine.

Clin Exp. Dermatol, 1989; 14: 98- 100.

Ryder NS. Terbinafine: mode of action and properties

of the squalene episodes’ inhibition. Br J Dermatol,

; 126(Suppl. 39): 2-7.

Tones TC. Treatment of dermatomycoses with

topically applied gailylamines: naftifine and

terbinafine. J Dermatol Treat, 1990; l (Suppl 2): 29-

Aergemann J, Zehender H, Sones T & Maibach 1.

Terbinafine levels in serum, stratum corneum, dermis

epidermis (without stratum corneum), hair, sebum

and eccrine sweat. Acta Derma Venereol (Stock),

; 71: 332-36.

Villars VV & Jones TC. Special features of the

clinical use of oral terbinafine in the treatment of

fungal diseases. Br J Dermatol, 1992; 126 (Suppl.

: 61-69.

Sanabria JA, Bonifza A & Saul A. Terbinafine

enaltratameinto de micosis superficial. Dermatology

(Mexico), 1990; 34: 189-98.

Leenutaphong V, Leowatttana W, Boonchai W, et al.

A randomized double blind comparative study of

terbinafine is griseofulum in tinea corporis and tinea

cruris dermatological treatments: preliminary

investigations in the Asia Pacific Region

proceedings, Asia-Pacific Dermatology symposium,

New York (NY, U.S.A.), 15 June 1992. (Evans EGU,

Jafary MH, eds) (International Congress and

symposium series, No. 197) London: Royal Society

of Medicine Services Ltd, 1992; 11- 15.

Frederickson T. Treatment of dermatomycoses with

topical tioconazole and miconazole. Dermatological,

; 166(Suppl. 1): 14-19.

White JE, Perkins PJ & Evans EGV. Successful 2-

week treatment with terbinafine (lamisil) for

moccasin tinea pedis and tinea manum. Br J

Dermatol, 1991: 125: 260-62.

Shear NH, Villars VV & Masolais C. Terbinafine: an

oral and topical antifungal agent. Clin Dermatol,

; 9: 487-95.

Jacobs PH. Treatment of fungal skin infection: state

of the art. J Am Acad Dermatol, 1990; 23: 549-51.

Most read articles by the same author(s)