PREVALENCE OF HEPATITIS B CARRIERS AND BLOOD GROUP FREQUENCY IN VOLUNTARY BLOOD DONORS
Abstract
Infection with Hepatitis B virus is a serious hazard. A study was carried out to evaluate the prevalence rate of HBsAg carrier state among a group of 200 healthy voluntary blood donors. Blood groups and haemoglobin levels were also determined. The prevalence rate for HbsAg carrier suite was 2% (males-1.09%, females11.11%). The frequency distribution of ABO blood groups was: A- 22.7%, B- 36.35%, O- 33.85%>, and AB- 7.10%. The percentage distribution of Rh antigen was: Rh+ve- 93.44% and Rh-ve- 6.56%. Haemoglobin level, mean value ±standard deviation, for males was 13.84 ±0.95 and in case of females it was 13.02±0.53. The study reveals that females exhibit greater seropositivity, group B is the commonest and males have significantly higher Hb levels. In order to estimate HBV, blood and all blood products must be tested for HbsAg. Moreover, Hepatitis B vaccine should be included in the Expanded Programme of Immunization in our country. KEYWORDS: Hepatitis B, HbsAg, Blood groups, ABO, Rh(D), HaemoglobinReferences
Deinhardt F, Abb J & Assad F. Viral hepatitis.
Bulletin of the WHO, 1983;61:203-6.
Vall Mayans M, Hall AJ, Inskip HM, et al. Risk
factors for transmission of hepatitis B virus to
Gambian children. Lancet 1990;336:1107-9.
Thursz MR, Kwiatkowski D & Alisopp CEM, et al.
Association between an MHC Class II allele and
clearance of hepatitis B virus in the Gambia. N Engl
J Med, 1995;332:1065-9.
Blumberg BS & Alter HJ. Precipitating antibodies
against a serum protein (Australia antigen in the
blood of a transfused haemophilia patient). J Clin
Inv, 1965;44:1029.
Zeldis JB, Shabib SM & Tufenkejl H. Diagnosis of
viral hepatitis (Editorial). Annals of Saudi Medicine,
; 15(1): 1-5.
Malik 1A, Tariq WVZ, Hassan ZU & Mahmood A.
Sub-classification of hepatitis B vims carriers.
JCPSP, 1996;6(1):4-5.
Attique MUH, Yousaf M, Haleem A & Hassan A.
Prevalence of hepatitis B virus in liver diseases in
Bahawalpur. JPGMI, 1990;4(1): 139-42.
Yousaf M & Yousaf N. Prevalence of hepatitis B
carriers among health care workers. Pak J Med Res,
;27:168-9.
Jabeen M, Hussain R, Siddiqui SA, Fayyaz A &
Saleem M.Prevalence of hepatitis B surface antigen
(HbsAg) in doctors, medical students and
paramedical staff working in Sir Ganga Ram
Hospital. Lahore. Pak J Med Res, 1995:34:172- 5
Alter MJ. Hadler SC & Margolis HS, et al. the
changing epidemiology of hepatitis B in United
States. JAMA, 1990;263:1218-22.
Parveen N. ABO and subgroup A in the Lahore
population. JPMA, 1987;37:200-1.
Jamal A. Ahmed MS. Ahmad A, Zafar MN & Syed
S. ABO and A subgroups in Karachi population.
JPMA, 1988;38:199-200.
Mustansar M & Ah I. Iron deficiency in women and
children specialists. Pak J Med Sci, 1995;
(4):323-5.
Hussain S, Khan AB, Ansari JK, Fazal I & Orakzai
A. Incidence and clinical aspects of hepatitis B in
naval hospital Karachi. PAFMJ, 1994;44(2):28-33.
Burney Ml. Spectrum of liver disease as studied at
the National Health Laboratories. National Seminar
on Liver Disease (Proceedings). PMRC Monograph
No 2, 1977;44.
Janjua IM & Hussain M. Hepatitis B vims surface
antigenaemia in voluntary blood donors and patients
with acute hepatitis. Pak J Med Res, 1990;29:160-2.
Malik 1A & Tariq WIJZ. Viral hepatitis in Pakistan
(Editorial). Pak J Path, 1993;4:1-5.
Lin HJ, Lai CL & Lau JYN. et al. Evidence for
intrafamilial transmission of hepatitis B virus from
sequence analysis of mutant HBV DNAs in two
Chinese families. Lancet, 1990;336:208-12.
Qureshi H. Post exposure prophylaxis of hepatitis B.
JPMA, March 1988;62-4
Nutritional anaemias. WHO Technical Report
Series, I972;502:29.
Dacies JV & Lewis SM. Practical Haematology.
Reference ranges and normal values. London, 7th
edition. Churchill Livingstone, 1991; 12.
Williams JR % Flowerdew ADS. Uptake of
immunization against hepatitis B among surgeons in
Wessex Regional Health Authority. BMJ,
:301:154.
Integrating hepatitis B vaccine into EPI programs
(WHO Special Report). Pak Paed J, 19; 17:85-7.