• Akhtar Hamid Malghani
  • Muhammad Tayyab
  • Allah Ditta
  • Haroon Rashid Chaudhry
  • Mohammad Saleem
  • Haleem -ud- Din
  • Naseer Ahmad Chaudrhy


A study was conducted to determine serum carbamazepine (CBZ) levels by high performance liquidchromatography (HPLC) and gamma glutamyl transferase (GGT) activity in 40, already diagnosedepileptic patients (20 males and 20 females) on CBZ therapy for more than six months. Twenty normalhealthy controls (JO males and 10 females) were included in the study. The mean f standard deviation ofCBZ level in all subjects, males (young and old, females young and old) were 4.2±2.76, 3.47±2.15,3.65±3.21 and 4.80±^3.27, 3.86 f 3.65 ug/ml respectively.While the GGT level in all the subjects were 50.57±23.36, in male 52.42 ±23.68 IU/L and in female48.5±23.28 IIJ/L. It was observed that the serum GT activity> in relation to daily- dosage of CBZ wasmore in old than young groups. The comparison between daily dosage and CBZ was weakly positive (r-0.2951) while serum CBZ versus serum GGT activity (0.09820), shows no correlation. Hence it wasconcluded that there is no significant correlation between serum CBZ level and serum GGT activity. Toavoid toxic effects of drug over dosage and to obtain therapeutic results drug monitoring is essential.


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