• Mohammad Ayub
  • Ahmed Badar
  • Mohammad Daud
  • Mohammad Yousaf
  • Farrukh A Khan
  • Nusrat Waqar


To compare the lung function of the people living at low and high altitude, spirometry was performed on 45 clinicallyhealthy male subjects native of Haripur, altitude 530 m. Above Sea Level (ASL) and another 45 male subjects werestudied for the same parameters from Nathiagali (altitude 2,530 m. ASL). Their age range was from 21 to 40 years.The spirometric values were significantly higher in the younger subjects from Nathiagali than their counterparts fromHaripur. However, the older subjects did not show any significant differences in their spirometric values except inForced Vital Capacity (FVC), indicating a rapid deterioration in the flow rates and expiratory' timings of the subjectsliving at Nathiagali. This may probably be explained as to be due to excessive exposure to cold, allergens. possiblymicro-organisms and smoke from wood-fire, which produce subclinical bronchitis in this population. Further detailedinvestigation in the problem to determine the real cause of rapid decline in the lung function of this population issuggested.


Ayub, M. Daud, M., Badar, A., Khan, F.A. and Nusrat

Waqar. Effect of Altitude on spirometric values.

JAMC, 1990; 3(2): 9-13.

Petty, T.L. Thr predictive value of spirometry.

Identifying patients at risk for lung cancer in the

primary care setting. Postgrad. Med. 1997; 101(3): 128-

, 133-4, 140.

Rao. V., Todd, T.R., Kuus, A., Buth, K.J., and Pearson,

F.G. Exercise oximetry versus spirometry in the

assessment of risk prior to lung resection. Ann. Thorac.

Surg. (1995); 60(3): 603-9.

Committee Recommendations. The assessment of

Ventilatory Capacity: Statement of the Committee on

Environmental Health and Respiratory Physiology,

American College of Chest Physicians. Chest, 975;67:


Cochrane, G.M., Prieto, F., and Clark, T.J.H.

Intrasubject variability of maximal expiratory flow

volume curve. Thorax, 1977; 32: 171-6.

Mognoni, P., Sailbene, F., and Veicsteinas, A.

Ventilatory Work During Exercise at High Altitude.

Int. J. Sports Med., 1982; 3(1): 33-6.

McFadden, E.R. Jr., and Linden, D.A. A reduction in

maximum mid-expiratory flow rate: A

spirometric manifestation of small airway disease. The

Am. J. Med., 1972; 52:725-37.

Gelb, A.F., and Klein, E. Clinical significance of

pulmonary function tests. The volume of is of low and

increase in maximal flow at 50 percent of forced vital

capacity during Helium-Oxygen breathing as test of

small airway dysfunction. Chest, 1977; 71: 396- 9

Lawther, P.J., Brooks, A.G.F., and Waller, R.E.

Respiratory function measurements in a cohort of

medical students: a ten-year follow-up. Thorax. 1978;

: 773-8.

Burki, N.K. (1982). Pulmonary Function Tests. In

Pulmonary Diseases, 1st Ed. pp 33-68. Medical

Examination Publishing Co. Inc., an excerpta Medical

Company, Garden City New York, U.S.A.

Knudson, R.J., Lebowitz, M.D., Holberg, C. J. and

Burrows, B. Changes in the Normal Maximal

Expiratory Flow-Volume Curve with Growth and

Ageing. Am. Rev. Respir. Dis., 1983; 127: 725-34.

Cotes, J.E., Ed. Selection and use of tests of lung

function: Reporting results. In Lung Function:

Assessment and Application in Medicine. 4th Ed.

(1979), pp 329-87. Blackwell Scientific Publications,


Ayub, M., Zaidi, S.H., and Burki, N.K. Spirometry and

flow-volume curves in healthy normal Pakistanis. Br. J.

Dis. Chest, 1987;81:35-45.

Most read articles by the same author(s)

1 2 3 > >>