EFFECTS OF PROTEIN MALNUTRITION ON THE THYROID FOLLICULAR CELL SIZE OF ALBINO RATS
Abstract
In this study, the effect of protein malnutrition and its reversal was observed in rats. A total of 80 male albino rats(Wistar strain) were used in this study. The animals of various groups were given isocaloric diet but the proteincontent of the diet varied from 2.5 to 20%. It was observed that protein malnutrition had an adverse though reversibleeffect on the thyroid follicular cell size of the albino rats. It is suggested that a similar study should be conducted tosee the effects of PEM on the thyroid hormones as well to correlate our study with the function of the gland.References
Davidson S., Passmore R., Brok J.F., Truswell A.S.
Proteins and Protein energy malnutrition. In: Human
Nutrition and Dietetics. 6lh edition, Churchill
Livingstone, Edinburgh. 1982; pp. 55-72, 303-316.
JAMC, Vol. 10, No. 2, 1998
Udani P.M. “Protein Energy Malnutrition (P.E.M),
Brain and various facets of child development”. Indian
Journal of Pediatrics, 1992; 59 (2): 165-186.
Khan M., Baker J. Protein Energy Malnutrition. In:
Nutrition and Health Care for the Young Child. Health
Publication Ltd. The Medical Centre, 58-Khyaban-eIqbal, Shalimar 7/2, Islamabad. 1979; pp. 49-54.
Khan M., Baker J. Protein Energy Malnutrition. In:
Nutrition in Primary Health Care. National Nutrition
Foundation, the Medical centre, 47-College Road,
Shalimar 7/2, Islamabad. 1988; pp. 72-80.
Rodwell S., Williams. Essentials of Nutrition and Diet
Therapy. 3rd edition, The C.V. Mosby Company, St.
Louis, Missouri. 1982; pp. 3-10,35-47 and 191.
Jacob S., Lawrence A.G. “Effects of Protein
malnutrition on the mouse submandibular gland”. J.
Anat, 1989; 165: 169-175.
Delverdier M., Cabanie P., Roome N., Enjalbert F., Van
Haverbeke G. “Quantitative Histology of Rat Thyroid.
Influence of Histologic Technique on the
Morphometric Data”. Analytical and Quantitative
Cytology and Histology; 1991a; 13, (2): 110-114.
Orien L.T., Patricia P. K., Danforth E., Horton E.S.
“Characteristics of Thyroid Function in Experimental
Protein Malnutrition”. J. Nutr. 1979; 109: 1321-1332.
Heard C.R.C., Stewart R.J.C. Protein-calorie
deficiency and disorders of the endocrine glands.
Hormones. 1971: 2: 40-64.
Fleagle J.G., Samonds K.W., Hegsted D.M. “Physical
growth of cebus monkeys, cebus albifrons, during
protein calorie deficiency”. Am. J. Clin. Nutr. 1975; 28:
-253.
Onura C., Maharajan G., Singh A., Etta K.M. “Thyroid
status in various degrees of protein-calorie malnutrition
in children”. Clin. Endocrinol. Oxf. 1983; 18(1): 87-93.
Ashraf T.S., Abd El Hadi H., Alan D.R. “Endocrine and
Amino acid changes in Protein Energy Malnutrition
(PEM)” Journal of Tropical Pediatrics 1991; 37: 331-
Alleyne G.A.O., Hay R.W., Picou D.I., Stanfield J.P.,
Whitehead, R.G. Protein Energy Malnutrition. Edward
Arnold Publishers Ltd. London. 1979; pp. 25-53.
Young R.A., Tulp O.L., Horton E.S. “Thyroid and
growth responses of young Zucker obese and lean rats
to a low protein-high carbohydrate diet”. J. Nutr. 1980;
(7): 1421-31.