• Sham Sher Ali Khan


The study was carried out on total {n = 160) normotensive patients for elective surgical procedures of shorter duration toevaluate the changes in blood pressure using different concentrations and rates of administration of Thiopentone Sodiumsolutions as induction agent. The study demonstrated that induction with Thiopentone sodium causes a fall in blood pressure,the more concentrated the solution (5 % solution) the more marked is the fall in the blood pressure as compared to the 2.5 %solution. The rapid injection (administered in 30 seconds) causes a rapid and more fall in blood pressure as compared toadministered in 1 minute. Atropine premixed with thiopentone causes inconsistent effect on blood pressure as compared tousing plain thiopentone sodium, and there is no significant difference between the male and female in their blood pressureresponse to thiopentone sodium. Meticulous care is needed in the administration of thiopentone along with pre-oxygenation inthe normal patients and particularly in those susceptible to its depressant effects such as those with raised blood pressure,elderly and cardiopulmonary compromised situations whereby it should be used slowly and in reduced dosage.


McCollum JSC and Dundee JW: Comparison of induction

characteristics of four intravenous anaesthetic agents.

Anaesthesia (1986) Vol 40;995-1000.

William J. Thomson. The effect of induction of anaesthesia

on peripheral hemodynamics. British J. Anaesthesia. 1967;

: 213.

Aitkenhead AR. Smith G. Text Book of Anaesthesia. 1990.

Lee J. Alfred. A synopsis of Anaesthesia.

Abdullah WY, Prof. M. Habib Department of Anaesthesia,

University of Basrah, J. Anaesth & Crit. Care vol 3, JulySept, (1997).

Fahy LT, Van Morik GA, Ultig JE: a comparison of the

induction characteristics of Thiopentone and Profol

Anaesthesia (1985);40:939-44.

j. Antonio Aldret, Trends in intravenous Anaesthesia.

Grounds RM, Twigley AJ, Carier F, Whitman J Band

Morgan M. The haemodynamic effects of intravenous

induction. Comparison of the effects of thiopentone and

propofol. Anaesthesia. 1985; 40:734-40.

Nielson PA, Schensller W, Christensen JH. Propofol

compared with thiopentone in young and elderly patients.

Anaesthesia 1988; (43 suppl): 121.

Lipmann et al. A controlled study of the haemodynamic

effects of propopfol vs thiopental during anaesthesia

induction. Anaesthesia and analgesia 1986; 65:589.

Saidman LJ. Uptake, distribution and elimination of

barbiturates in Eger El (ed) Anaesthetic uptake and action.

Willioums and Wilkins Baltimore: P-5.

John W. Dunde. Thiopentone and other thiobarbiturates.

Morgan DJ. Blackmangi, Paul JD and Wolf U.

amiacokineticass and plasma binding of Thiopental.

Anaesthesiology (1981); 554:482-7.

Toner W. et al. Anaesthesia 1979; 34: 657.

Aditorial. Anaesthesiology 1979; 50: 284.

Caird FI. Oxford text book of Medicine University

Press1987; 27: 1.

Goldman LJ. Cardiothoracic. Anaesth 1987; 1: 237.

Steib A, Freysg et al. Propofol in elderly high risk patients.

comparison of Haemodynamic effects with thiopentone

during induction of anaesthesia. Anaesthesia 1988;

(supplu): 111-4.

Foster WH. Et al. Anaesthesiology 1977; 47: 741.

Hundson RJ, Stanski DR. Burch PG. Pharmacokinetics of

methohexital and thiopental in surgical patients.

Anaesthesiology 183; 59: 215-9.

Haely TE, Jand Wilkins RC, Ann. R. Coll. Surg 1984; 66:

John T. Martin. Positioning in anaesthesia and surgery. 2IKl

Edition 1987; 59-60.

Brown SS et al. Br. J. Anaesth 1968; 40: 13.