EFFECT OF PROTEIN MALNUTRITION ON THE WEIGHT AND SERUM ALBUMIN OF ALBINO RATS
AbstractBackground: Protein Malnutrition is one of the major mortality factors in the children of Pakistan. Not only do the children sufferfrom infections (because of low resistance secondary to malnutrition), but they also lose weight significantly. The two spectra ofthe diseases are Kwashiorkor and Marasmus. We conducted this study on laboratory' animals to assess the weight change andcorrelated it with the extent of malnutrition by studying and estimating the serum albumin levels as well. Methods: 40 male albinorats of 2 weeks’ age were used for the experiment. They were divided into Control and Experimental groups containing equalnumber of animals. The experimental group was subjected to protein malnutrition for 3 to 6 weeks. They were killed with thepaired control animals. The parameters of the two groups were compared for statistical analysis. Results: The results showedsignificant change in the weights of the experimental animals right from the first week of malnutrition while the change in serumalbumin level became significant after prolonged malnutrition. Conclusion: Protein malnutrition is reflected from the decrease inthe serum albumin levels of the animals and their weights are also decreased significantly.
Davidson S.. Passmore R.. Brok .I F., Truswell A.S. Proteins
and Protein energy malnutrition. In: Human Nutrition and
Dietetics. 6th edition, Churchill Livingstone. Edinburgh.
; pp 55-72, 303-316.
Udani P.M. "Protein Energy Malnutrition (P.E.M), Brain and
various facets of child development". Indian Journal of
Pediatrics, 1992; 59 (2): 165-186 Khan M., Baker J. Protein
Energy Malnutrition. In: Nutrition in Primary Health Care for
the young child Health publication Ltd., the Medical centre,
Khyaban-e-Iqbal, Shalimar 7/2, Islamabad. 1979; pp. 45-
Khan M.. Baker J. Protein Energy Malnutrition. In: Nutrition
in Primary Health Care. National Nutrition Foundation, the
Medical centre, 47-College Road. Shalimar 7/2. Islamabad.
; pp. 72-80.
Rodwell S., Williams. Essentials of Nutrition and Diet
Therapy. 3rd edition. The C.V, Mosby Company, St. Louis,
Missouri. 1982; pp. 3-10,35-47 and 191.
Muaku S.M., Beauloye V., Thissen J.P.. Underwood L.E..
Fossion C.. Gerard G. Ketelslegers J.M. “Long term effects of
gestational protein malnutrition on postnatal growth, Insulin
like growth factor (IGF)-I and IGF binding proteins in rat
progeny". Pediatr Res 1996 Apr; 39(4ptl ):649-55.
Ramos C.F., Teixeira C.V., Passos M.C., Pazos-Moura C.C..
Lisboa P.C., Curty F.H., de Moura E G. “Low protein diet
changes thyroid function in lactatin rats". Proc Soc Exp Biol
Med 2000 Sep; 224(4):256-63.
Qureshi M l.. Draz U., Feroze, N.. Jafri S.A. “Effects of protein
malnutrition on the thyroid follicular cell size of albino rats".
Jacob S.. Lawrence A.G. "Effects of Protein malnutrition on
the mouse submandibular gland" J. Anat, 1989; 165 169- 175.
Delverdier M . Cabanie P.. Roome N., Enjalbert F , Van
Haverbeke (}.: “Quantitative Histology of Rat Thyroid
Influence of Histologic Technique on the Morphometric
Data". Analytical and Quantitative Cytology and Histology.
a; 13, (2): 110-114.
Orien L.T.. Patricia P K.. Danforth E; Horton E S.
"Characteristics of Thyroid Function in Experimental Protein
Malnutrition". J. Nutr. 1979; 109 1321-1332.
1 I Heard C.R.C.. Stewart R.J.C. Protein-calorie deficiency
and disorders of the endocrine glands. Hormones. 1971.2: 40-
Fleagle J.G.. Samonds K W., I legs ted D.M. "Physical growth
of cebus monkeys, cebus albifrons. during protein calorie
deficiency". Am. J. Clin.Nutr. 1975; 28: 246-253.
13 Escriva F., Kergoat M., bailbe D., Pascual-Leone A M..
Portha B. “Increased Insulin action in the rat after protein
malnutrition early in life". Diabetologia 1991: Aug; 34(8): 5
Resnik O., Morgane P.J., Hasson R.. Miller M “Overt and
hidden forms of chronic malnutrition in the raland their
relevance to man". Neurosci Biobehav rev 1982
Tulp O.L., Horton E.S. “Effect of prolonged experimental
protein malnutrition and of refeeding on growth, adipose tissue
development and body composition in rats". J Nutr 1981 Jul;
16 Onura C., Maharajan G,. Singh A., Etta K.M. "Thyroid
status in various degrees of protein-calorie malnutrition in
children". Clin. Endocrinol. Oxf. 1983; 18(1): 87-93.
Ashraf T.S., Abd EL, Hadi H., Alan D.R. "Endocrine and
Amino acid changes in Protein Energy Malnutrition (PEMJ"
Journal of Tropical Pediatrics 1991; 37:331-332
Alleyne G A.O, Hay R W„ Picou D.I . Stanfield J.P .
Whitehead. R.G. “Protein Energy Malnutrition". Edward
Arnold Publishers Ltd. London. 1979; pp. 25-53.
Akingbemt B.T., Aire T.A. “Haematological and serum
biochemical changes in the rat due to protein malnutrition and
gossypo;-abanol interactions". J Comp pathol 1994 Nov;
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