SERUM SIALIC ACID LEVEL IN DIABETIC RETINOPATHY
AbstractBackground: The purpose of the study was to investigate the previously reported observations that patients withelevated levels of serum sialic acid are more prone to develop retinopathy. Methods: Fasting blood glucose and serumsialic acid levels were estimated in sixty diabetic patients with and without retinopathy between 30-60 years of age.Thirty normal persons of same age group were included as controls. Fundoscopy was done to confirm retinopathy.Serum sialic acid concentration was elevated in diabetic patients both with and without retinopathy but the increasewas much significant in patients with diabetic retinopathy. Results: A significant correlation of serum sialic acid levelwith duration of diabetes and degree of retinal involvement was noticed in this study
Tattersall R-B. Diabetes in elderly a neglected area?
Diabetologia 1984:27: 167-73
American Academy of Ophthalmology Quality Care
Committee. (1993) Preferred practice pattern for diabetic
retinopathy. American Academy of Ophthalmology, 665
Beach St San Francisco, CA 9424.
Engerman R. Relationship of microvascular disease in
diabetes to metabolic control. Diabetes, 1977: 26: 760-69.
Kohner E.M. Diabetic eye disease in complications of
diabetes: Edward Arnol London 1982; 19-108, as quoted in W
H O. Technical report series, 1985.
Ciaraldi TP. Neuraminidase treatment of isolated rat
adipocytes and differential regulation of basal and insulin
stimulated glucose transport Diabetes 1989:38 951-58.
Stryer L. Biochemistry 2nd Eds. W.H. Freeman New
Crook M The determination of plasma or serum Sialic Acid
Clin Biochem. 1993:26:31-38
Alvi M H, Shaikh S.A. Serum sialic acid as tumour marker and
the effect of therapy in cancer patients. Proceedings
Hayes B.K and Varki A.O. Acetylation and di-o-acetylation of
sialic acid. J. Biol. Chem. 1989; 264(32): 19443-7
Bergmeyer H.U, Bergmeyer J, Grable H Methods of
enzymatic analysis, 3rd Eds, Vol-1. Florida, Value Chem.
Alvi M.H, Amer N, Sumrin I. Serum 5-Nucleotidasc and
serum sialic acid in pregnancy. Obstet. Gynaecol 1988 72:171-
Plucinsky M.C, Rily W.M, Prorok J.J. and Alhadett J A. Total
and lipid associated serum sialic acid levels in cancer patients
with different primary sites and differing degrees of metastatic
involvement. Cancer 1986; 58:2680-85.
Ekhe G I and Ibeh G O Sialic acid in Sickle cell disease. Clin.
Syrbe G, Schroder H, Keil E. and Jutte A. Multivariate
analysis for understanding typical diabetic homeostasis,
criteria and determination of typical retinopathy parameter.
Folia Haematol. Int Mag Klin Morphol Blutfprsch
Rehman and Rehman a Studies on glycosylated plasma
proteins in diabetes mellitus. JPMA.1991; 41(17): 16-18.
Jons A and Wales J K Blood glycoprotein j levels in diabetes
mellitus. Diabetologia, I976; l2:245
Korte G E. Labelling of regenerating retinal pigment
epithelium by colloidal iron oxide and ferritin. Cell tissue
research 1991,264(1): 103-110.
Rehman M.A, Zafar G, and Shera AS. Changes glycosylated
protons in long diabetes mellitus. Biomed Pharmcother