PREVALENCE OF THYROID MICROSOMAL AND THYROGLOBULIN AUTOANTIBODIES IN GOITROUS LESIONS
Abstractbackground: this prospective study was done to evaluate the serum levels of microsomal and thyroglobulinautoantibodies in patients with toxic diffuse goiter and nodular goitre (non-toxic) undergoing radio-iodinetherapy and thyroidectomy respectively. methods: forty-eight patients suffering from thyroid disorders. 29 withnodular goiter and 19 with toxic diffuse goitre (TDG) and 15 age & sex-matched normal controls were studied.thyroid microsomal (MSAB) and thyroglobulin autoantibodies (TGAB) were estimated in the sera of all thesubjects using the commercially available kits based on tanned red cell haemagglutination technique. results:MSAB seropositivity in TDG and nodular goitre was found to be 78.9% and 51.7% respectively. on the otherhand, TGAB seropositivity was 57.9% and 27.6% in cases of TDG and nodular goitre. 13.3% and 6.7% of thenormal controls were positive for MSAB and TGAB respectively. Conclusion: These findings indicate thatautoimmunity is thyroid disorders implicated in the genesis of commonly occurring
Rout IM. Donaich D. Campbell PN. Hudson RV
Autoantibodies in Hashiinoto's disease (Lymph adenoid
goitre) Lancet. 1956.2 820-21
Ditta A. Tavyab M. Chaudhry NA. Malik MA I hyperthyroid
Graves' disease: thyroglobulin autoantibody and clinical
presentation Biomedical. 1994.10:75-78
Selcnkow HA. Wyman P. Allais P Autoimmune thyroid
diseases: An integrated concept of Graves and Hashimoto's
disease. Comprehensive therapy 1984:10(4)48-58
Taniani H. Nakagavva T. Ohaska N. Fukino O. Takahashi II.
Matsuzuka F et at. Changes in thyroid function in patients with
euthyroid Graves' disease. J. Clin Endocrinol Metab.
Hirota Y. Tamai II. Hayashi Y. Mitsubishi S. Malsuzuka. Klim
K Et al. Thyroid function and histology in forty-five. patients
with hyperthyroid Graves* disease in. clinical remission more
than ten years after thionamidc drug treatment. J Clin
Endocrinol Metab 1986,62.165-169.
Rapaport B. Autoimmune mechanisms in thyroid disease. In;
Circen WI. cd The Thyroid New York1 Elsevier 1987 47-106.
Hamad N. Jaeduck N, Portman L, I to K. DeGroot U.
Antibodies against denatured and reduced thyroid microsomal
antigen in autoimmune thyroid disease J Clin Endocrinol
MacLauchlan SM. Feldt-Ramussin V. Young ET, et al. IgG
subclass distribution of thyroid autoantibodies: A finger print”
of an individual response to thyroglobulin and thyroid
microsomal antigens. Clinical Endocrinol Oxf 1987:26:335-
Khourey El. Mammon L, Bottazzo GF. Domeach D. Presence
of the organ specific “microsomal autoantigen on the surface
of human thyroid cell in culture: its involvement in
complement mediated cytotoxicity. Clin Exp. Immunol 1981;
Bonger U. Schleusever H. Wall JR. Antibody dependent cell
mediated cytotoxicity against human thyroid cells in HT but
not GD. J Clin Endocrinol Metab 1984:59:734.
1 I. Beal GN. Solomon DM. Diseases of the thyroid In:
Semester M, ed Immunological disease. Toronto: Little Brown
Kausar N. T ay yah M, Ditta A Abid SM and Chaudhry NA.
Clinical importance of thyroid peroxidase autoantibodies
(TPO-AB) in pregnancy Pak J Med Res. I998;37(1): 19-22
Rose NR. Witebsky F. Studies on organ specificity: Changes
in the thyroid glands of rabbits following immunization with
rabbit thyroid extracts. J Immunol J956; 76:417.
Lucas-Mart in A. Foz-Sala M. Todd I. Bortuzzo GF, PujoIIBurrell R Occurrence of thyrocyte HLA Class II expression in
a wide variety of thyroid diseases: Relationship with
lymphocytic infiltration and thyroid autoantibodies J e lm
Endocrinol Metab 1988 66:367-75
Bland M an introduction of medical statistics lull. Oxford.
New York. Tokyo: Oxford University Press 1988 149-21 l
Tayyab M. Kausar N. Allah F3itla TSM Receptor
autoantibodies in Graves' disease before and after anti-thyroid
drug therapy. Biomedical. 1999:15:27-32.
Matin A, Matsuoka N. Concepcion ES. Davies IT Endogenous
antigen presentation by autoantigcn-iransfcrrcd Epstein-Barr
virus lymphoblastoid cells: T cell receptor N- region
hydrophobicity relates to thyroid antigen recognition
Groot I J. Larsen PR, Refetoff S, Stan hurry. IB (cds) In: The
thyroid and its diseases Ed5. New York Wiley Medical
Amino N Thyroid directed antibodies. In log bar Ml. Brevet in
LI: (eds) The Thyroid A fundamental and clinical text.
Philadelphia: JB Lippmeott Co, 1986 546-559.
Grades' A, Blottner A. Domek H. Comparison of
autoantibodies level in thyroid autoimmune diseases estimated
by different methods. Exp Clin Endocrinol 1988:92 77-84.
Scherbaum WA. On the clinical importance of thyroid
microsomal and thyroglobulin antibody determination. Acta
Endocrinol (Copenh) 1987:281 328-29
Zeeman B, Lisak RP. Autoantibody Autoimmunity and
Immune Complex in Todd H (cd): Clinical diagnosis and
management by laboratory methods Toronto/London' JB
Lippincott H Co. 1984:924-51.
Tayyab M. Allah Ditta. Malik MA. Khan SWA. Chaudhry
NA. Significance of thyroid microsomal antibody in Graves*
disease. JPMA; 1993:41:11 -13.
Gardas A, Bauer A. An immunoenzyme method of
determining serum levels of ant microsomal antibodies
Endocrinol-Pol, 1989.40 189-98.
Brown RS. Immunoglobulins affecting thyroid growth: a
continuing controversy (editorial). J Clin Endocrinol Metab.
Dewa M. Molecular aspects of the pathogenesis of nodular
goiters, thyroid nodules and adenomas. Exp. Clin Endocrinol
Yoshida H, Amino N, Yagawak, Chemurak, Satoh M. Miyai
K Et al. Association of scrum ant thyroid antibodies with
lymphocytic infiltration of the thyroid gland: Studies on
seventy autopsied cases. J. Clin Endocrinol Metab :|
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.