• Muhammad Tayyab
  • Khal1l-Ur- Rehman Bhatt
  • Allah Ditta


background: this prospective study was done to evaluate the serum levels of microsomal and thyroglobulinautoantibodies in patients with toxic diffuse goiter and nodular goitre (non-toxic) undergoing radio-iodinetherapy and thyroidectomy respectively. methods: forty-eight patients suffering from thyroid disorders. 29 withnodular goiter and 19 with toxic diffuse goitre (TDG) and 15 age & sex-matched normal controls were studied.thyroid microsomal (MSAB) and thyroglobulin autoantibodies (TGAB) were estimated in the sera of all thesubjects using the commercially available kits based on tanned red cell haemagglutination technique. results:MSAB seropositivity in TDG and nodular goitre was found to be 78.9% and 51.7% respectively. on the otherhand, TGAB seropositivity was 57.9% and 27.6% in cases of TDG and nodular goitre. 13.3% and 6.7% of thenormal controls were positive for MSAB and TGAB respectively. Conclusion: These findings indicate thatautoimmunity is thyroid disorders implicated in the genesis of commonly occurring


Rout IM. Donaich D. Campbell PN. Hudson RV

Autoantibodies in Hashiinoto's disease (Lymph adenoid

goitre) Lancet. 1956.2 820-21

Ditta A. Tavyab M. Chaudhry NA. Malik MA I hyperthyroid

Graves' disease: thyroglobulin autoantibody and clinical

presentation Biomedical. 1994.10:75-78

Selcnkow HA. Wyman P. Allais P Autoimmune thyroid

diseases: An integrated concept of Graves and Hashimoto's

disease. Comprehensive therapy 1984:10(4)48-58

Taniani H. Nakagavva T. Ohaska N. Fukino O. Takahashi II.

Matsuzuka F et at. Changes in thyroid function in patients with

euthyroid Graves' disease. J. Clin Endocrinol Metab.


Hirota Y. Tamai II. Hayashi Y. Mitsubishi S. Malsuzuka. Klim

K Et al. Thyroid function and histology in forty-five. patients

with hyperthyroid Graves* disease in. clinical remission more

than ten years after thionamidc drug treatment. J Clin

Endocrinol Metab 1986,62.165-169.

Rapaport B. Autoimmune mechanisms in thyroid disease. In;

Circen WI. cd The Thyroid New York1 Elsevier 1987 47-106.

Hamad N. Jaeduck N, Portman L, I to K. DeGroot U.

Antibodies against denatured and reduced thyroid microsomal

antigen in autoimmune thyroid disease J Clin Endocrinol

Metab 1987;64:230-238

MacLauchlan SM. Feldt-Ramussin V. Young ET, et al. IgG

subclass distribution of thyroid autoantibodies: A finger print”

of an individual response to thyroglobulin and thyroid

microsomal antigens. Clinical Endocrinol Oxf 1987:26:335-

Khourey El. Mammon L, Bottazzo GF. Domeach D. Presence

of the organ specific “microsomal autoantigen on the surface

of human thyroid cell in culture: its involvement in

complement mediated cytotoxicity. Clin Exp. Immunol 1981;


Bonger U. Schleusever H. Wall JR. Antibody dependent cell

mediated cytotoxicity against human thyroid cells in HT but

not GD. J Clin Endocrinol Metab 1984:59:734.

1 I. Beal GN. Solomon DM. Diseases of the thyroid In:

Semester M, ed Immunological disease. Toronto: Little Brown


Kausar N. T ay yah M, Ditta A Abid SM and Chaudhry NA.

Clinical importance of thyroid peroxidase autoantibodies

(TPO-AB) in pregnancy Pak J Med Res. I998;37(1): 19-22

Rose NR. Witebsky F. Studies on organ specificity: Changes

in the thyroid glands of rabbits following immunization with

rabbit thyroid extracts. J Immunol J956; 76:417.

Lucas-Mart in A. Foz-Sala M. Todd I. Bortuzzo GF, PujoIIBurrell R Occurrence of thyrocyte HLA Class II expression in

a wide variety of thyroid diseases: Relationship with

lymphocytic infiltration and thyroid autoantibodies J e lm

Endocrinol Metab 1988 66:367-75

Bland M an introduction of medical statistics lull. Oxford.

New York. Tokyo: Oxford University Press 1988 149-21 l

Tayyab M. Kausar N. Allah F3itla TSM Receptor

autoantibodies in Graves' disease before and after anti-thyroid

drug therapy. Biomedical. 1999:15:27-32.

Matin A, Matsuoka N. Concepcion ES. Davies IT Endogenous

antigen presentation by autoantigcn-iransfcrrcd Epstein-Barr

virus lymphoblastoid cells: T cell receptor N- region

hydrophobicity relates to thyroid antigen recognition

Autoimmunity. 1995:21:223-3.

Groot I J. Larsen PR, Refetoff S, Stan hurry. IB (cds) In: The

thyroid and its diseases Ed5. New York Wiley Medical

publications. 1984.412-39.

Amino N Thyroid directed antibodies. In log bar Ml. Brevet in

LI: (eds) The Thyroid A fundamental and clinical text.

Philadelphia: JB Lippmeott Co, 1986 546-559.

Grades' A, Blottner A. Domek H. Comparison of

autoantibodies level in thyroid autoimmune diseases estimated

by different methods. Exp Clin Endocrinol 1988:92 77-84.

Scherbaum WA. On the clinical importance of thyroid

microsomal and thyroglobulin antibody determination. Acta

Endocrinol (Copenh) 1987:281 328-29

Zeeman B, Lisak RP. Autoantibody Autoimmunity and

Immune Complex in Todd H (cd): Clinical diagnosis and

management by laboratory methods Toronto/London' JB

Lippincott H Co. 1984:924-51.

Tayyab M. Allah Ditta. Malik MA. Khan SWA. Chaudhry

NA. Significance of thyroid microsomal antibody in Graves*

disease. JPMA; 1993:41:11 -13.

Gardas A, Bauer A. An immunoenzyme method of

determining serum levels of ant microsomal antibodies

Endocrinol-Pol, 1989.40 189-98.

Brown RS. Immunoglobulins affecting thyroid growth: a

continuing controversy (editorial). J Clin Endocrinol Metab.

; 80:1506-1508

Dewa M. Molecular aspects of the pathogenesis of nodular

goiters, thyroid nodules and adenomas. Exp. Clin Endocrinol

Diabetes. 1996:4:32-37.

Yoshida H, Amino N, Yagawak, Chemurak, Satoh M. Miyai

K Et al. Association of scrum ant thyroid antibodies with

lymphocytic infiltration of the thyroid gland: Studies on

seventy autopsied cases. J. Clin Endocrinol Metab :|


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