PREVALENCE OF HEPATITIS E VIRUS (HEV) ANTIBODY IN PREGNANT WOMEN OF KARACHI

Authors

  • RABIA SHAMS
  • RAZIA BAHADUR KHERO
  • TOUSEEF AHMED
  • Amtul Hafiz

Abstract

Background: This study was aimed at determining the prevalence of HEV in Karachi. Methods: Prevalence ofhepatitis | antibody in pregnant women was carried out in 65 pregnant women. They had history of acute viral hepatitiswhile 15 control pregnant women were included having no history of jaundice. Results: The statistical outcome of thepresent study indicates prevalence of HEV as 57% in pregnant women with jaundice. Majority of the patients (85%)were from lower socio-economic strata., with mean age of 25 years. All these patients had hemoglobin less than10gm%. The mean ALT level in HEV positive cases was 452 IU/L over a range of 102-5328. It was also observedthat HEV affected more women in the last trimester (62%) and in primigravida (67%). It was observed that it wasmore common in last trimester and in primigravida. Majority of the patients (85%) were from lower socio-economicstrata. Conclusions: The findings of the present study proved the presence of HEV in pregnant women and confirmedthat HEV is endemic in Karachi. The study confirms that it occurs in last trimester and in young adult.

References

Jawetz, E., Metnick, J.L. and Adelberg, E.A.

Hepatitis virus in Medical Microbiology, 19th

Ed., Printed in the United States of America.

, pp. 451-467.

Malik, I.A. and Tariq, W.Z. (1996). Hepatitis E, A

Pakistan perspective. 10th Biennial Scientific

Meeting Asian Pacific Association for the study of

liver, Rawalpindi, Pakistan,265-274.

Bradley, D.W. and Balayan, M.S. (1988). Virus of

enterically transmitted Non-A. Non-B hepatitis.

Lancet, 9:819

Qureshi. M.S., Ahmad, M., Khan, F.A., Mushtaq,

S. and Ahmed S.A. (1987) Acute sporadic viral

hepatitis A-seromarker study in 50 consecutive

cases. J.P.M.A.:231-233.

Khuroo, M.S., Teli, M R., Skidmore, S., Soti, M.A.,

Khuroo, M.I. (1981). Incidence and severity of

viral hepatis in pregnancy. The Am. J. Med.,

:252-255.

Sjogren, Col. M.H. (1993). Hepatic Emergencies

in pregnancy. Med. Clin. North Am. 77:1115-27.

Ramalingaswami, V, and Purcell, R.H. (1988).

Water borne Non-A, Non-B hepatitis. Lancet,

:571.

Bile, K., Isse, A., Mohamud, O., Nilsson, P.A.L.,

Norder, H., Mushahwar, I.K. and Magnius, L.O.

(1994). Contrasting roles of river and wells as

sources of drinking water on attack and fatality

rates in a hepatitis E epidemic in Somalia. Am. J.

Trop live 51:466-474.

Smergo. JR and Khlaiq A.A (1988) Epidemic

Non –A Non-B Hepatitis in urban Karachi

Pakistan Trop Med Hyg. 38:628-632

Malik I A and Tariq. W.Z (1995) The prevalence

and pattern of viral hepatitis in Pakistan. JCPSP.

2.3

Purdy. M.A and Kawarzynski, K (1994). Hepatitis

E. Gasteroteronal Clin. North Am. 233: 537 – 546

Liang. T.J Jeffers. I, Reddy, R.K., Silva ChenOver

H., Findor. A . Medina. MD., Yarbough, P.O.,

Reyes, G.R., Schiff, E.R. (1993) Fulinant or

subfulminant Non-A, Non –B, viral hepatitis: The

role of hepatitis C and E viruses Gastroenterol.

:556-562

Tsega. E . Krawcznski. K.. Hansson, B.G.,

Nordenfelt. E (1993). Hepatitis E virus infection

in pregnancy in hiopia Ethiop Med. J.. 31:173-

Chaudhry. G.H.. Qazi, A.W. and Noor. N.A.

(1994). Acute viral hepatitis in pregnancy.

Specialist Pak. J Med. Sci . 10(30) 245-50

Berhanmanesh. F. Hagluighi. P., Hehmat. K,

Rezaizadeh. K., Ohavami, A.G. (1973). Viral

hepatitis during pregnancy. Gastrocntcrolo..

:304-312.

Kazrni, and junejo. F ( 1 9 9 3 ) Hepatitis E

epidemic in Islamabad Pak. j. of Med. Research

(Editorial),32(4):249-51

Pangl.. Allencar H.l-.C, JR..C.C, Milhous w.k

Andrade R - 1995. short report Hepatitis E

infection in the Brazilian Amazon. Am J Trop

Hyg. 52(4) 199 347-348

Bryan J.P, Tsarev. S.A. Iqbal. M. Treehurst;

Emerson. Emerson S. Ahmed. A, Duncan. J.

Rafique A.R. Malik EA, Purcell R.H, Legters. L.J.

(1994). Epidemic hepatitis E in Pakistan. Patterns

of Serological Response and evidence that

antibode to hepatitis E. Protect against disease.

The Journal of Infection disease, 170: 517:21

J Ayub Med Coll 2001: 13(3)

D’curz, I A Balani, S.G. lyer.1.1 (1968).

Infectious hepatitis and pregnancy J. Obs Gynac.,

(4) 449-55.

A Gan, E.A, Menon, T., Valliammai, Paul, DA

Burroughs, Gunamanann, D., Dhevalri b. (1994).

Equivocal serological diagnosis or sporadic

fulminant hepatitis E in pregnant Indians Lancet

:342-343

Khan, R.u . l.A Malik, Siddiqui, S., Taricl, W.U.Z

Hast, C A. (1995). Sporadic hepatitis S virus in

Pakistan. Ann. of tropical Medi. and Parasitology

Vol 8, 89(1)95-97.

Lok, A.S, Kwan, W., Moeckli. R, Yarbough. P.

Chan.. R.T., Reyes, G.R., Lai, C.L, Chung, H.T.,

Lai. TST (1992). Sero epidemiological survey of

hepatitis E in Hong Kong by recombinant-based

enzyme immuno assay. Lancet, 340.1205-8.

Maclean, A.B. and Cockbur, F. Maternal and

perinatal infection in: Dewhurst’s Textbook of

Obstetrics and Gynaecology for postgraduates,

Fifth ed., Black Well Science Ltd., North America,

, pp.477-493.

Malik, l.A. and Tariq, W.Z. (1995). The

prevalence and pattern of viral hepatitis in

Pakistan. JCPSP. 5:2-3

AM Walim and VA- Arankalle (1999) Retrospect!

Serological analysis of hepatitis E patient a .ang

terum

follow-up- study J. viral-Hepat-1999 Nov 6 (6)

-61.

J.L Smith (1999) food borne infection during

pregnancy. J. food-port. 1999 July:62 (7): 818-29

JJ Drabick J. Seriwatana BL-Innis (1998)

Sero Prevalence of hepatitis E Virus among

United Nations in Haiti. Peace Keepers, 1995.

Am. J Trop-Med Hug Jun 58(6):731-6.

Downloads