COMPARISON OF AZTREONAM AGAINST OTHER ANTIBIOTICS USED IN URINARY TRACT INFECTIONS
Abstract
Background: Urinary tract infection is a very common problem in adults as well as in children. There is always needfor the right antibiotic to be chosen for treatment. Methods: This study was conducted at Microbiology section inPathology department of Ayub Medical College, Abbottabad, Pakistan. In this study the aztreonam which is onlyeffective against gram negative bacilli has been compared with other conventionally used antibiotics, ampicillin,cotrimoxazole, minocycline, pipemedic acid, nalidixic acid, norfloxacin, ciprofloxacin, gentamicin and ceftriaxone.Results: Total gram negative isolates were 342. Out of this 76.6% (262) were E.coli. Klebsiella pneumoniae 14.3%(49), proteus species 5.2%(I8) and pseudomonas aeruginosa were 3.8% (13). The aztreonam showed 78% sensitivityagainst gram negative bacilli which is better than norfloxacin which showed 62.2% sensitivity.References
Finkelstein-R. Kassis-E, Reinhertz-G i al. Communityacquired urinary tract infections in adults: a hospital viewpoint.
J-Hosp-lnfect. 1998 Mar; 38(3): 193-202
Aug-B.S. Urinary tract infections. Singapore Medical Journal,
June; 36(3): 314-7.
Bertram G. Katzung; Ernest Jawetz. Penicillins and
cephalosporins in basic and clinical pharmacology fifth edition
; 626-636. Applarton and Lange; Norwalk. Connecticut.
Sharifi-R; Geckler-R; Childs-S. Treatment of urinary tract
infections; Selecting an appropriate broad-spectrum antibiotic
for nosocomial infections. American Journal of Medicine ,1969;
I00(6A). 765-828
Grau-S, Monterde-J. Dronie-L & Salvado-M. Management of
urinary tract infections: a comprehensive review. Pharm- WorldSci. 1997 Oct; 19(5): 236-45.
Gruenberg RN & Bettelheim KA. Geographical variation in
serological types of urinary Escherichia Coli. Journal of Medical
Microbiology, 1969; 2: 219.
Ishikawa-K; Suzuki-K; Higa-1. Comparative susceptibility of 10
antimicrobials against pseudomonas Kansenshojakn- Zasshi,
June; 70(6): 584-590.
Turck. M. & W. Stamm Nosocomial infection of urinary tract.
American Journal of Medicine. 1981; 70 651-654.
MacCaig DJ. Stewart D. Harvey Y. Downie S. Scott C’J. An
assessment of antibiotic therapy of urinary tract infections in
elderly hospitalized patients. Health Bulletin Edinburgh. 1995.
(6); 359-64.
Papapctroponlou M, Pagonoponlou O, Konskonni E. Prevalence
and sensitivity to antibiotics of enterobacteriaceae isolated from
urinary cultures in some microbiology laboratories of a city in
Greece. Pathol Biol Paris 1997 Nov; 45(9):7 l6-20