THE INCIDENCE OF NON ULCER DYSPEPSIA AND ITS RESPONSE TO TREATMENT
AbstractBackground: This study was undertaken to identify Non Ulcer Dyspepsia (NUD) in young patients presenting withpeptic ulcer like symptoms. Their response to treatment was also determined. Methods: 100 patients between the agesof 20-40 of both sexes were included in the study. Investigations done were Chest X-ray Plain Abdominal X-ray.ECG, ESR, LFTs Amylase Abdominal Ultrasound and upper G1 endoscopy. All, patients then received 6-weektherapy with Omeprazole and Helicobacter Pylori eradication with Clarithromycin and tinidazole. Results: NUD wasby far the most common cause (59°/o) in both the sexes. Response to therapy was unsatisfactory. Conclusions: Thisrelatively newly discovered clinical entity should be kept in mind while dealing with patients presenting withrefractory dyspeptic symptoms
Barbara I, Camilleri M. Corinaldesi GP, Crean RC et at
Definition and investigation of dyspepsia, consensus of an
international Ad Hoc working party. Dig Dis Sci 1989;
Talley NJ, Phillips .SI'. Non-ulcer dyspepsia: potential causes
and pathophysiology Ann Intern Med 1988,108 865-79.
Johannessen T. Fjosne U; Kleveland P.M. Scand. ill
Gastroenterol. 1988:23/3 (327-36).
Jaakkimainen Rl. el al Is Helicobacter pylori associated with
non-ulcer dyspepsia and will eradication improve symptoms?
A meta-analysis. BMJ October 16,1999.319.1040-44.
Laheij RJF. Jansen JBMJ. van dc lisdonk till. Severens JL,
Verbeek ALM. Review article: symptom improvement
through eradication of Helicobacter pylori in patients with
non-ulcer dyspepsia. Aliment Pharmacol Ther 1996; 10:843-
Greenberg PD. Cello JP. Lack of effect of treatment for
Helicobacter pylori on symptoms of non-ulcer dyspepsia Arch
of Intern Med 1999; 159:2283-88.
Talley NJ. Vakil N, Ballard ED. Fennerty MB. Absence of
benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia. N Engl J of Med 1999:341(15): 1106- 1HL
VK Shukla, N Otten, C Dube. D Moher. Use of cisapride in
patients with non-ulcer dyspepsia: a meta-analysis of
randomized trials. Ottawa. Canadian Coordinating Office for
Health Technology Assessment (CC'OHTA): 2000