AbstractParathyroid carcinoma is a very rare cause of primary hyperparathyroidism and these tumors areusually hyper-functioning as compared to other malignant endocrine tumors. Surgery is the onlyeffective primary treatment. We report a patient, who presented with pathological fracture offemur, hypercalcemia, bilateral renal stones, markedly raised Parathormone levels and palpablemass in the neck. Parathyroid adenoma was initially diagnosed and localized at left lower gland bySestamibi scan and ultrasonography. She underwent surgery and enlarged parathyroid gland wasremoved. Intra operatively there was no evidence of local invasion or lymph nodes involvementbut biopsy report suggested malignancy.Keywords: Parathyroid carcinoma, Adenoma, Primary hyperthyroidism, Sestamibi scan.
Kulkarni PS, Parikh PM. The carcinoma of parathyroid
gland. Indian J Cancer 2004;41(2):51-9.
Agrawal R, Agarwal A, Kar DK, Agarwal G, Jain M,
Krishnani N, et al. Parathyroid carcinoma. J Assoc
Physicians India 2001;49:990-3.
Clayman GL, Gonzalez HE, El-Naggar A, VassilopoulouSellin R. Parathyroid carcinoma: evaluation and
interdisciplinary management. Cancer 2004;100(5):900-5.
Iacobone M, Lumachi F, Favia. Up-to-date on parathyroid
carcinoma: analysis of an experience of 19 cases. J Surg
Oncol 2004; 88(4):223-8
Bhansali A, Kataria RN, Dutta P, Saha MM, Singh P, Dash
RJ. Parathyroid Carcinoma: Difficult Management Options.
Ind J Cancer 2002;39(3)119-22
Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar
AK, Clayman GL et al. Parathyroid carcinoma: a 22-year
experience. Head Neck. 2004 Aug; 26(8):716-26