ASSESSMENT OF LIPID DYSFUNCTION IN PATIENTS ON MAINTENANCE HAEMODIALYSIS
AbstractBackground: Dyslipidaemia is a major risk factor of cardiovascular disease in patients onmaintenance haemodialysis. Both increased and decreased levels of cholesterol are associatedwith increased cardiovascular mortality in haemodialysis patients. Objective: To assess the lipiddysfunction among patients on maintenance haemodialysis in a nephrology unit at Rawalpindi ascompared with healthy individuals. Methodology: A descriptive comparative study was carriedout in a nephrology unit at Rawalpindi, Pakistan. A total of 140 subjects were included consistingof 70 patients on maintenance haemodialysis (MHD) and 70 healthy controls. Body mass index(BMI) was measured according to WHO guidelines. Serum total cholesterol (TC), triglycerides(TG) and high-density lipoprotein cholesterol (HDL-C) were assayed on chemistry analyser.Low-density lipoprotein cholesterol (LDL-C) was calculated by Friedwald equation. Result:MHD patients had significantly lower BMI, mean (SD) 20.07(3.66) as compared with the controls22.88(3.97) kg/m2 (p<0.001). The lipid profile among MHD patients and controls are given asmean (SD): (a) Total Cholesterol 3.84(1.06) vs 4.65(0.97) (p<0.001), (b) LDL-C 2.21(0.77) vs2.93(0.71) (p<0.001), (c) HDL-C 0.95(0.166) vs 0.97(0.138) (p=NS), (d) Non HDL 2.88(0.95) vs3.67(0.88) (p<0.0001), (e) Triglycerides 1.68(1.09) vs 1.69(0.86) (p=NS). The most commonabnormality observed in haemodialysis patients was low HDL-C (81%) followed by increasedNon-HDL-C (23%) and increased serum triglycerides (19%). Conclusion: It is concluded thatour patients on maintenance haemodialysis have significantly low BMI, total Cholesterol, LDL-Cand Non-HDL-C depicting malnutrition leading to inflammation, accelerated atherosclerosisprocess and cardiovascular complications.Key words: total Cholesterol, lipoproteins, BMI, haemodialysis, cardiovascular disease
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