• Abdus Samad Syed
  • Fauzia Abdus Samad
  • Mahmood ur Rahman


Non Hodgkin’s Lymphoma (NHL) comprises a group of lymphoproliferative disorders thefrequency of which continues to rise. Although many classification systems exist foridentifying specific histological subtypes, NHL is generally divided into indolent (low-grade)and aggressive (intermediate- and high-grade) forms. Large B Cell Lymphoma (LBCL) is oneof the commonest aggressive NHLs. The aim of this review is to provide a general overviewof NHL, its clinically practicable cellular classification, epidemiology and in depth overviewof the evolution of treatment of LBCL during the past 5 years. Current guidelines fromNational Cancer Institute (NCI), USA and National Institute on Clinical Excellence (NICE),UK are mentioned and recommendations according to our own set-up are suggested.Keywords: Non-Hodgkin’s Lymphoma, Large B Cell Lymphoma, Rituximab


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