• Mir Muhammad Sohato
  • Ghulam Murtaza Rajper
  • Abdul Qayoom Memon
  • Gulshan Menton
  • Muhammed Tayab
  • Haleemuddin Khan


The study was carried on 60 albino rats of 8 weeks’ age. These rats were divided into five (n=12) each groups. Low Fat (LF) (5%) diet group and High Fat (HF) (20%) diet groups i.e.Olive Oil (00), Corn Oil (CO) & Butter Fat (BF) group respectively. I IF diet was given for 12weeks and then the diets were admixed with cholesterol and Propylthiouracil fat for the next20 weeks. LF diet group were divided into two groups after 12 weeks. Once received LF dietand the other received HF diet with cholesterol and PTH. In our study the serum cholesterollevel increased in HF (20%) diet group. The LF (5%) diet, CO (20%), OO (20%) decreasedthe serum cholesterol level before the supplementation of atherogenic elements but it slightlyincreased the serum cholesterol level after atherogenic supplementation. On the other end BFdiet increased the serum cholesterol level before and after atherogenic supplementation.However, the tissue cholesterol level increased 3 fold in all type of tissues in BF diet group ascompared to other diet groups. Least rise in tissue cholesterol level were seen in CO diet group.


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