LONG TERM EFFECTS OF DIETARY FAT/OILS ON SERUM AND TISSUE CHOLESTEROL LEVEL IN ALBINO RATS
AbstractThe study was carried on 60 albino rats of 8 weeks’ age. These rats were divided into five (n=12) each groups. Low Fat (LF) (5%) diet group and High Fat (HF) (20%) diet groups i.e.Olive Oil (00), Corn Oil (CO) & Butter Fat (BF) group respectively. I IF diet was given for 12weeks and then the diets were admixed with cholesterol and Propylthiouracil fat for the next20 weeks. LF diet group were divided into two groups after 12 weeks. Once received LF dietand the other received HF diet with cholesterol and PTH. In our study the serum cholesterollevel increased in HF (20%) diet group. The LF (5%) diet, CO (20%), OO (20%) decreasedthe serum cholesterol level before the supplementation of atherogenic elements but it slightlyincreased the serum cholesterol level after atherogenic supplementation. On the other end BFdiet increased the serum cholesterol level before and after atherogenic supplementation.However, the tissue cholesterol level increased 3 fold in all type of tissues in BF diet group ascompared to other diet groups. Least rise in tissue cholesterol level were seen in CO diet group.
Ahrens 1:11, Incull WJ, Bloom Strand R, Hirsch .1 and
Peterson MI. The influence of dietary fats on serum
lipid level in man. Lancet, 1957: 1:943-53.
Barrows KK, Keeg TR, Me Gilliared 111) Effect of
type of dietary facts on plasma and tissue cholesterol. J
Nutrition 1980: 110: 325-342.
Beveridge Jac R. Cannel VVF. Mayai GA, Hanst HL
and White M. Plant sterol, degree of unsaturation and
hypercholesterolemic action of certain fats. Canadian
.1. Bioehem Physiol, 1957; 36: 895-99.
Bieri JG. Stoewsand CIS. Briggs GM. Philips RW.
Woodard JC and Kapka .1.1. Report of American
Institute of Nutrition. adhoc committee of standard for
nutrition studies J. Nutr. 1997; 107(7): 1340-48.
Bronte SB. Antonis A, Porles J, Brok .1.1. Effect of
feeding different fats on serum cholesterol levels.
Lancet 1956: I: 521-61.
Beynen AC and Katan MB. Why do polyunsaturated
fatty acids lower serum cholesterollevels. Am. J. Clin.
Nutr. 1985:42: 560-63
Connor WE. Witaik of. Stone DB, and Armstrong ML.
Cholesterol balance and faecal neutral sterile and bill
acid excretion in normal men fed dietary fats of
different fatty acid composition. .1. Clin. Invest.
De-Gesquet Pde. Griegleo SE, Planche Ps. Malewaik
Ml. Diurnal changes in plasma and liver lipids and
dietary' in heart and adenose tissue inrats fed high and
low fat diet. .1 Nutr. 1977: 107: 199-212
Goldstein JL, Brown MS. Familial
hypercholesterolemia in; Stanberry JB, Wyngaarden
JB. Fredrickson DS, Gmsten JC, Brown MS. Editors:
The metabolic bases of inherited disease, 5th Edition
New York: McGraw Hill Book Co. Inc. 1983: Chap.33:
Grundy MS. Goodman WS, Rifkind BM. Cleeman JJ.
The place of HDL-C in cholesterol management. Arch
Intern. Med. 1989; 199: 305-510.
Grundy MS. Vega GL. Influence of mevenoline on
metabolism of LDL-C in primary moderate
hypocholesteremia. .1. Lipid Res. 1985: 26: 1469-75.
Hulbron G. Probert A, Franine B and Baniel L. Early
cholesterol feeding all their long term effects in the rats.
J Nutri 1982; 112: 1296-1305.
Mey A. Diet and epidemiology of coronary heart
disease. JAMA 1957; 164: 1912-19.
Lewis B. Chait A, Caklcy CMO. Serum lipoprotein
abnormalities in patients with ischemic heart disease
comparison with control population. Brit. J Med. 1974;
Ney DM, Laskan JB, and Kim J. Relative effects of
dietary oleic and linoleic rich diet on plasma
lipoproteins composition in rats. J. Nutri. 1989: 19:
Oh Sy and Manaco PA. Effective of dietary cholesterol
and degree of fat unsaturation on plasma lipid levels,
lipoprotein composition and faecal steroid excretion in
normal young adult men. Am. .1. Clin. Nutr 1985: 92:
Thompson LE. Elevation of coronary suspect. Med J
: 135: 134-32.