PLASMA ANTITHROMBIN LEVELS OF PAKISTANI WOMEN WITH PRE-ECLAMPSIA
AbstractPlasma antithrombin HI level/activity was determined in the gravid Pakistani women. Levels of AT III weresignificantly decreased in pre-eclamptic women compared to normal pregnant controls. The degree ofreduction in plasma A T III level was correlated with the severity of the disease. In no instance was lowplasma AT III associated with normal pregnancy. The relation of decreased AT III level may he valuableas a tool in diagnosing pre-eclampsia as a screening test/predictor, and as an indicator of severity ofdisease.
Anonymous. ECPPA: Randomised trial of low dose
aspirin for the prevention of maternal and foetal
complications in high risk pregnant women. ECPPA
(Estudo collaborative para Preuencao da Pre-eclampsia
com aspirina) collaborative group. Br .1 Obst Gynaecol
; 103(1): 39-47
Akhtar J, Qureshi R. Rahim F. Et al. Diabetes in
pregnancy in Pakistani women: Prevalence and
complications in an indigenous South Asian
community. Diabetic Med 1996; 13(2): 189-91
Howie PW, Purdie DW. Begg CB, Prentice CRM. Use
of coagulation tests to predict the clinical progress of
pre- eclampsia. Lancet 1976: 2: 323
Gant NF. Daley Gl. Grand S. Whalley PJ, MacDonald
PC. A study of angiotension-II presser response
throughout primigravid pregnancy. .1 Clin Invest 1973,
Gant NF. Chand S. Worley R.I. Whalley PJ. et al. A
clinical test useful for predicting the development of
active hypertension in pregnancy. Am .1 Obstet
Gynecol 1974; 120:1
Stander HJ, Cadden. IF. Blood chemistry in preeclampsia and eclampsia. Am .1 Obstet Gynecol
Redman CWG. Williams GF. Jones DD. Wilkinson
BH. Plasma urate and serum deoxycytidylate
deaminase measurements for the early diagnosis of preeclampsia. Br .1 Obstet Gynaecol 1977:84:904.
Bonnar .1, Redman CWG. Denson KW. fire role of
coagulation and fibrinolysis in preeclampsia. In:
Lindhime MD, Katz Al, Zuspan EP (eds). I
Hypertension in pregnancy New York J Wiley and Sons
Weiner CP. Pre-eclampsia - eclampsia syndrome and
coagulation Clin Perinatol 1991: 18(4): 713-26.
Buller FIR. Wenink ADH, Treffers PE, et al. Severe
antithrombin III deficiency in a patient with preeclampsia. Scand J Haematol 1980; 25: 81
Mackie M, Bennet B. Ogoston E. et al. Familial
thrombosis: Inherited deficiency of antithrombin 111.
Br Med J 1978; I: 136.
VonKaulla E. VonKaulla KN. Antithrombin 111 and
disease. Am J Clin Pathol 1967: 48: 69
Banerjee BN. Sahni AL. Kumar V. et al. Antithrombin
III deficiency m maturity onset diabetes mellitus and
atherosclerosis. Thromb Diath Haemorr 1974; 31: 339
Pusterla N. Braun LJ, Forrer R. Lutz I I. Antithrombin
activity in plasma of healthy and sick cattle. Vet Rec
; 140: 17- 18
Weiner CP. Brandi J. Plasma antithrombin III activity:
an aid in the diagnosis of preeclampsia. Am .1 Obstet
Gynecol 1982; 142: 275.
Xu C. Zhou L. Shong S. Wang S, Zhang M, Weiner
CCP. Antithrombin 111 activity in Chinese women
with preeclampsia Thromb Res 1990; 59: 401-6.
Armstrong NP. Teisner 13. Redman CW. Westergaard
JG, Flkersen J. Grudzinshas JG. Complement
activation, circulating protease inhibitors and
pregnancy associated proteins in severe preeclampsia
Br. J Obstet Gynaecol 1986: 93(80): 811-14.
18 Kobayashi T. Terao T. Pre-eclampsia as chronic
disseminated intravascular coagulation Gynecol Obstet
Invest 1987; 24: 170.
Weiner CP The mechanism of reduced antithrombin III
activity in women with preeclampsia. Obstet Gynecol
: 72: 847-47.
Dickneite G. Paques CP. Reduction of mortality with
antithrombin III in septicemic rats: A study of
Klebsiella pneumoniae induced sepsis. Thrombosis and
Haemostasis (c) I K. Schattaver Verlagsgesellschaft
mbH (Stuttgart) 1993; 69(2): 98-102.
Paternoster D, Sierra A. Simioni P, Trovo S. Plebani P.
Girolami A. Clotting inhibitors and fibronectin as
potential markers in pre-eclampsia. hit .1 Gynecol
Obstet 1994, 47(3): 215-21
Savelieva CM. Elimov VS. Grishni VL. Shalma Rl.
Kashezhera AZ. Blood coagulation changes in pregnant
women at risk of developing pre-eclampsia. bit .1
Gynaecol Obstet 1995:48(1): 3-8.
Grow I. Campbell DM. Ogoston D Blood levels of
proteinase inhibitors in pre-eclampsia Br .1 Obstet
Gynaecol 1983; 90(10): 950-52.
Beller FK. Dame WR. Ebert C. Pregnancy induced
hypertension complicated by thrombocytopenia,
haemolysis and elevate liver enzymes (I IELLP)
syndrome Reval biopsies and outcome Aust NZ .1
Obstet Gynaecol 1985: 25: 83-86.
Brinkman III CR. Hypertensive disorders of pregnancy.
In: Hacker NF. Moore G. l (eds). Essentials of
Obstetrics and Gynaecology. 2nd Ed. London: VVB
Saunders Company. 1992; 163-74.
Kauffman RH, de Grief J, dela Riviene GB, Vanes LA.
Unilateral renal vein thrombosis and nephrotic
syndrome. Report of a case with protein sensitivity and
antithrombin III clearance status. Am J Med 1976;
Lau OS. Tkachuck Y. l. Haegawa KD. Edson RJ
Plasminogen and antithrombin 111 deficiencies in the
childhood nephrotic syndrome associated with
plasminogenuria and antithrombin. .1 Paedtr 1980; 96:
Robert A. Olmer M. Sampol .1. Guhliotta EJ.
Casanorea P Clinical correlation between
hypercoagulability and thromboembolic phenomenon
Kidney International 1987; 31: 830-35
Weiss EA. Acquired coagulation disorders. In:
Corrivean MD, Eritsma AG (eds). Hemostasis and
Thrombosis in the Clinical Laboratory. Philadelphia:
JB Lippincott Company. 1988 169- 205
Cameron.IS. Clinical consequences of the nephrotic
syndrome. In: Cameron JS. Dawison AM. Grurifeld.
IP. Kerr DNS. Ritz E (eds). Textbook of Clinical
Nephrology. London: Oxford University Press, 1992:
31 Olds RJ. Lane DA. Mille B. Chowdhury V. Them
SL Antithrombin: The principal inhibitor of thrombin.
Seminars in thrombosis and hemostasis. 1994: 20(4):
Florell SR. Rodgers GM. Inherited thrombotic
disorders: An update. Am .1 Haematol 1997; 54 53-60
Wenink GIL Treffers PE. Vi j in P. Smorenberg-School
E. Ten-Cate JW. Antithrombin 111 levels in preeclampsia correlate with maternal and fetal morbidity
Am .1 Obstet Gynecol 1984; 148: 1092-97
Aghai GH, Brunstein .1, Quit M. Abrarnovicci H, I
room P. Antithrombin III levels in preeclampsia. Isr Jr
Med Sci 1990; 26: 142-43
Brandt P. Jespersen J, Gregersen G Postpartum
haemolytic uremic syndrome treated with antithrombin
III. Nephron 1981; 27(1): 15-18
Lieberman JR. Hagary ZJ. Mazor M, Wiznitzer A.
Aharon M. Nathan I, Dvilansky A. Plasma
antithrombin III levels in pre- eclampsia and chronic
hypertension. Int J Gynaecol Obstet 1988: 27(1): 21-24
Terao K. Maki M. Ikenone T. et al. The relationship
between clinical signs and hypercoagulable state in
toxemia of pregnancy. Gynecol Obstet Invest 1991: 31:
Weiner CP. Brandt J. Plasma antithrombin III activity
in normal pregnancy. Obstet. Gynecol 1980; 56: 601
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