PLASMA ANTITHROMBIN LEVELS OF PAKISTANI WOMEN WITH PRE-ECLAMPSIA

Authors

  • Muhammad Tariq Hamid Rahmani
  • Muhammad Tayyab
  • Tahira Tasneem

Abstract

Plasma antithrombin HI level/activity was determined in the gravid Pakistani women. Levels of AT III weresignificantly decreased in pre-eclamptic women compared to normal pregnant controls. The degree ofreduction in plasma A T III level was correlated with the severity of the disease. In no instance was lowplasma AT III associated with normal pregnancy. The relation of decreased AT III level may he valuableas a tool in diagnosing pre-eclampsia as a screening test/predictor, and as an indicator of severity ofdisease.

References

Anonymous. ECPPA: Randomised trial of low dose

aspirin for the prevention of maternal and foetal

complications in high risk pregnant women. ECPPA

(Estudo collaborative para Preuencao da Pre-eclampsia

com aspirina) collaborative group. Br .1 Obst Gynaecol

; 103(1): 39-47

Akhtar J, Qureshi R. Rahim F. Et al. Diabetes in

pregnancy in Pakistani women: Prevalence and

complications in an indigenous South Asian

community. Diabetic Med 1996; 13(2): 189-91

Howie PW, Purdie DW. Begg CB, Prentice CRM. Use

of coagulation tests to predict the clinical progress of

pre- eclampsia. Lancet 1976: 2: 323

Gant NF. Daley Gl. Grand S. Whalley PJ, MacDonald

PC. A study of angiotension-II presser response

throughout primigravid pregnancy. .1 Clin Invest 1973,

: 2682

Gant NF. Chand S. Worley R.I. Whalley PJ. et al. A

clinical test useful for predicting the development of

active hypertension in pregnancy. Am .1 Obstet

Gynecol 1974; 120:1

Stander HJ, Cadden. IF. Blood chemistry in preeclampsia and eclampsia. Am .1 Obstet Gynecol

:28:856.

Redman CWG. Williams GF. Jones DD. Wilkinson

BH. Plasma urate and serum deoxycytidylate

deaminase measurements for the early diagnosis of preeclampsia. Br .1 Obstet Gynaecol 1977:84:904.

Bonnar .1, Redman CWG. Denson KW. fire role of

coagulation and fibrinolysis in preeclampsia. In:

Lindhime MD, Katz Al, Zuspan EP (eds). I

Hypertension in pregnancy New York J Wiley and Sons

; 85.

Weiner CP. Pre-eclampsia - eclampsia syndrome and

coagulation Clin Perinatol 1991: 18(4): 713-26.

Buller FIR. Wenink ADH, Treffers PE, et al. Severe

antithrombin III deficiency in a patient with preeclampsia. Scand J Haematol 1980; 25: 81

Mackie M, Bennet B. Ogoston E. et al. Familial

thrombosis: Inherited deficiency of antithrombin 111.

Br Med J 1978; I: 136.

VonKaulla E. VonKaulla KN. Antithrombin 111 and

disease. Am J Clin Pathol 1967: 48: 69

Banerjee BN. Sahni AL. Kumar V. et al. Antithrombin

III deficiency m maturity onset diabetes mellitus and

atherosclerosis. Thromb Diath Haemorr 1974; 31: 339

Pusterla N. Braun LJ, Forrer R. Lutz I I. Antithrombin

activity in plasma of healthy and sick cattle. Vet Rec

; 140: 17- 18

Weiner CP. Brandi J. Plasma antithrombin III activity:

an aid in the diagnosis of preeclampsia. Am .1 Obstet

Gynecol 1982; 142: 275.

Xu C. Zhou L. Shong S. Wang S, Zhang M, Weiner

CCP. Antithrombin 111 activity in Chinese women

with preeclampsia Thromb Res 1990; 59: 401-6.

Armstrong NP. Teisner 13. Redman CW. Westergaard

JG, Flkersen J. Grudzinshas JG. Complement

activation, circulating protease inhibitors and

pregnancy associated proteins in severe preeclampsia

Br. J Obstet Gynaecol 1986: 93(80): 811-14.

18 Kobayashi T. Terao T. Pre-eclampsia as chronic

disseminated intravascular coagulation Gynecol Obstet

Invest 1987; 24: 170.

Weiner CP The mechanism of reduced antithrombin III

activity in women with preeclampsia. Obstet Gynecol

: 72: 847-47.

Dickneite G. Paques CP. Reduction of mortality with

antithrombin III in septicemic rats: A study of

Klebsiella pneumoniae induced sepsis. Thrombosis and

Haemostasis (c) I K. Schattaver Verlagsgesellschaft

mbH (Stuttgart) 1993; 69(2): 98-102.

Paternoster D, Sierra A. Simioni P, Trovo S. Plebani P.

Girolami A. Clotting inhibitors and fibronectin as

potential markers in pre-eclampsia. hit .1 Gynecol

Obstet 1994, 47(3): 215-21

Savelieva CM. Elimov VS. Grishni VL. Shalma Rl.

Kashezhera AZ. Blood coagulation changes in pregnant

women at risk of developing pre-eclampsia. bit .1

Gynaecol Obstet 1995:48(1): 3-8.

Grow I. Campbell DM. Ogoston D Blood levels of

proteinase inhibitors in pre-eclampsia Br .1 Obstet

Gynaecol 1983; 90(10): 950-52.

Beller FK. Dame WR. Ebert C. Pregnancy induced

hypertension complicated by thrombocytopenia,

haemolysis and elevate liver enzymes (I IELLP)

syndrome Reval biopsies and outcome Aust NZ .1

Obstet Gynaecol 1985: 25: 83-86.

Brinkman III CR. Hypertensive disorders of pregnancy.

In: Hacker NF. Moore G. l (eds). Essentials of

Obstetrics and Gynaecology. 2nd Ed. London: VVB

Saunders Company. 1992; 163-74.

Kauffman RH, de Grief J, dela Riviene GB, Vanes LA.

Unilateral renal vein thrombosis and nephrotic

syndrome. Report of a case with protein sensitivity and

antithrombin III clearance status. Am J Med 1976;

(7): 1048-54.

Lau OS. Tkachuck Y. l. Haegawa KD. Edson RJ

Plasminogen and antithrombin 111 deficiencies in the

childhood nephrotic syndrome associated with

plasminogenuria and antithrombin. .1 Paedtr 1980; 96:

-92.

Robert A. Olmer M. Sampol .1. Guhliotta EJ.

Casanorea P Clinical correlation between

hypercoagulability and thromboembolic phenomenon

Kidney International 1987; 31: 830-35

Weiss EA. Acquired coagulation disorders. In:

Corrivean MD, Eritsma AG (eds). Hemostasis and

Thrombosis in the Clinical Laboratory. Philadelphia:

JB Lippincott Company. 1988 169- 205

Cameron.IS. Clinical consequences of the nephrotic

syndrome. In: Cameron JS. Dawison AM. Grurifeld.

IP. Kerr DNS. Ritz E (eds). Textbook of Clinical

Nephrology. London: Oxford University Press, 1992:

-85

31 Olds RJ. Lane DA. Mille B. Chowdhury V. Them

SL Antithrombin: The principal inhibitor of thrombin.

Seminars in thrombosis and hemostasis. 1994: 20(4):

-72

Florell SR. Rodgers GM. Inherited thrombotic

disorders: An update. Am .1 Haematol 1997; 54 53-60

Wenink GIL Treffers PE. Vi j in P. Smorenberg-School

E. Ten-Cate JW. Antithrombin 111 levels in preeclampsia correlate with maternal and fetal morbidity

Am .1 Obstet Gynecol 1984; 148: 1092-97

Aghai GH, Brunstein .1, Quit M. Abrarnovicci H, I

room P. Antithrombin III levels in preeclampsia. Isr Jr

Med Sci 1990; 26: 142-43

Brandt P. Jespersen J, Gregersen G Postpartum

haemolytic uremic syndrome treated with antithrombin

III. Nephron 1981; 27(1): 15-18

Lieberman JR. Hagary ZJ. Mazor M, Wiznitzer A.

Aharon M. Nathan I, Dvilansky A. Plasma

antithrombin III levels in pre- eclampsia and chronic

hypertension. Int J Gynaecol Obstet 1988: 27(1): 21-24

Terao K. Maki M. Ikenone T. et al. The relationship

between clinical signs and hypercoagulable state in

toxemia of pregnancy. Gynecol Obstet Invest 1991: 31:

-85

Weiner CP. Brandt J. Plasma antithrombin III activity

in normal pregnancy. Obstet. Gynecol 1980; 56: 601

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