SERUM TESTOSTERONE LEVELS IN YOUNG MALE PATIENTS WITH MAJOR DEPRESSION

Authors

  • Aziz ur Rehman Yousafzai
  • Muhammad Yousuf
  • Muhammad Jan
  • Ahmed Badar

Abstract

Background: Testosterone affects neurobehavioral functions in men. It has positive effects on the mood. The availablestudies suggest that some depressed older men may have state-dependent low testosterone levels and that somedepressed men may improve with androgen treatment. This study was done to look for relationship of testosteronelevel with major depression in young patients. The daytime testosterone level and nighttime testosterone level in thesubjects was also compared. Methods: 25 young patients admitted in psychiatry7 unit of Ayub Teaching Hospital inthe age range 25-35 years were randomly selected for the study. It was ascertained that none of the subjects wassexually abnormal before the onset of disease. Daytime sample was taken at 12 noon while the nighttime sample at12 midnights. The testosterone level was done by radioimmunoassay. The results were compared with matchingcontrols. Results: The daytime and nighttime means were compared between the controls and subjects. Both the valueswere significantly lower in the depressed subjects. The value of nighttime testosterone was significantly more thanthe daytime testosterone in the depressed subjects. Conclusion: Testosterone level is significantly decreased in youngpatients with major depression.

References

Dickerman RD; McConathy WJ. Testosterone, vasopressin and

depression. Prog Neuropsychopharmacol Biol Psychiatry 1997

Jan;21(1) :247-8

Seidman SN; Walsh BT. Testosterone and depression in aging

men. Am J Geriatr Psychiatry 1999 Winter;7(l): 18-33

Booth A; Johnson DR; Granger DA. Testosterone and men's

depression: the role of social behavior. J Health Soc Behav 1999

Jun.40(2): 130-40

Schweiger U; Deuschle M; Weber B; Korner A Lammers CH;

Schmider J; Gotthardt U; Heuser I. Testosterone, gonadotropin.,

and cortisol secretion in male patients with major depression.

Psychosom Med 1999 May-Jun;61(3):292-6

Seidman SN; Rabkin JG. Testosterone replacement therapy for

hypogonadal men with SSRI-refractory depression. J Affect

Discord 1998 Mar,48(2-3): 157-61

Baumgartner A; Graf KJ; Kurten I; Meinhold H Scholz P. Neuroendocrinological investigations during sleep deprivation in

depression. I. Early morning levels of thyrotropin, TH, cortisol,

prolactin, LIT FSH. estradiol, and testosterone. Biol Psychiatry

Oct l;28(7):556-68

Steiger A; von Bardeleben U; Wiedemann K; Holsboer F. Sleep

EEG and nocturnal secretion of testosterone and cortisol in

patients with major endogenous depression during acute phase and

alter remission. J Psychiatry Res 1991,25(4): 169-77

Rinieris PM; Malliaras DE; Batrinos ML; Stefanis CN.

Testosterone treatment of depression in two patients with

Klinefelter's syndrome. Am J Psychiatry 1979 Jul;136(7):986-8

Yesavage JA; Davidson J; Widrow L; Berger PA. Plasma

testosterone levels, depression, sexuality, and age. Biol Psychiatry

Feb;20(2):222-5

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