GL YCOHEM OG LOB IN AND INCIDENCE OF CORONARY HEART DISEASE

Authors

  • Nargis Jamil
  • Mohammad Shafiq
  • Kausar Tasneem
  • Ghosia Lutfullah
  • Jamil ur Rehman

Abstract

Background: Presence of glucose on Hb1-c is established and represents a post translational glycosylation by a slownon-enzymatic process occurring during the 120 days’ life span of RBCs. It is an indicator of long term glycemiccontrol. Glycohemoglobin is directly related to blood glucose level. Methods: 50 randomly selected diabetic patientswere included and divided into two groups B and C of 25 subjects each. The subjects of group C were the diabeticswho were confirmed cases of CHD. while group B were the diabetics without any complications. Group A consistedof healthy controls (n=25). Glycohemoglobin was determined by column chromatography while blood glucose wasestimated by enzymatic method. Results: Blood glucose was increased in both the patient groups (p<0.001).Comparison of HbA| revealed a highly significant rise (p<0.001) in both the groups against normal control subjectsof group A. Correlation of Hb1-c with glucose in all the three groups was directly positive (r=+0.4). Conclusions: Theresults of the present study suggest an association between HbA1-c hyperglycemia and the incidence of CHD indiabetics.

References

Kennedy. L. and Lyons, T.J. (1989). Non enzymatic

glycosylation, Br. Med. Bull 45(9): 174-90.

Dunn, L, F. (1982). Hyperlipidemia and diabetes Med. Clin.

N. Am, 66(6): 1347.

Kenneth, H., Gabbay, K.H. Jan, 1... Breslow R. Curtis, E.H.,

Franklin, B. and Paul, M.G. (1977). Glycosylated

hemoglobin’s and long term blood glucose control in

diabetes mellitus. .1. tin Endocrinol Metah. 144(5): 859-64.

Mceance, D.R Hanson, R.L., Charles, M.A., Jacobson. L.T.H.

Pewttit. D. Benett. P.H. and Knowler. W.C (1994).

Comparison of tests for glycated hemoglobin and fasting and

two hours plasma glucose concentrations as diagnostic

methods for diabetes. B.M. J. 1323-8.

Gabhay. K. H. (1982). Glycosylated hemoglobin and diabetes

mellitus. symposium on diabetes mellitus. Med Clin. N. Am.

(6): 1301-

Kayaba, K., Nago, N., Miyamoto, T. and Mizooka, .VI.

(1989). Glycated hemoglobin levels and their correlation with

atherosclerotic risk factors in a Japanese population the Jichi

medical school Cohort study 1993-95. Jpn-Cir- J;62(4):261 -

Steffes, M.W. (1997). Glycemic control and the initiation and

progression of the complications of diabetes mellitus. KidneyInt- Suppl.63:936-9

Rehnian, J. and Rehman. VI. A. (1991). Studies on

glycosylated plasma proteins in diabetic patients J. Pak. Vied.

Assoc. 41(1): 15-8

Pickup, J.C., Mattock, VI.B.. Crook. M.A.. Chusney. G.D.,

Burt D. and Fitzgerald, A.P. (1995). Serum sialic acid

concentration and coronary artery disease in

NIDDVl. Diabetes care: 18(8): 11003-3.

Koeing, R.J., Peterson, C.M., Jones, R;L., Ssaudek, C.,

Lehrman, VI. and Carami. A. (1976). Correlation of glucose

regulation and hemoglobin Al-c in diabetes mellitus. N,

Engl. J. Med. 295:417-20

Jain, S.K., Movie, R., Jaramillo, J.J. and Chen. Y. (1998)

Hyperketonemia (aceto acetate) increase the oxidizability of

LDL & vldl IN TYPE-1 DIABETIC PATIENTS. Free

Radie-Biol-Me;24(l): 175-81.

Martinez, O.M.A., Heranz, M.L., Martin, V.P., Macro, M.A.,

Grande, C., Alvero, Fetal. (1997). The metabolic control of

insulin-dependent diabetes mellitus and diabetic nephropathy.

(Abstract). Lin-Esp. 197(1): 18-22

Issue

Vol. 12 No. 2 (2000): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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