• Nargis Jamil
  • Mohammad Shafiq
  • Kausar Tasneem
  • Ghosia Lutfullah
  • Jamil ur Rehman


Background: Presence of glucose on Hb1-c is established and represents a post translational glycosylation by a slownon-enzymatic process occurring during the 120 days’ life span of RBCs. It is an indicator of long term glycemiccontrol. Glycohemoglobin is directly related to blood glucose level. Methods: 50 randomly selected diabetic patientswere included and divided into two groups B and C of 25 subjects each. The subjects of group C were the diabeticswho were confirmed cases of CHD. while group B were the diabetics without any complications. Group A consistedof healthy controls (n=25). Glycohemoglobin was determined by column chromatography while blood glucose wasestimated by enzymatic method. Results: Blood glucose was increased in both the patient groups (p<0.001).Comparison of HbA| revealed a highly significant rise (p<0.001) in both the groups against normal control subjectsof group A. Correlation of Hb1-c with glucose in all the three groups was directly positive (r=+0.4). Conclusions: Theresults of the present study suggest an association between HbA1-c hyperglycemia and the incidence of CHD indiabetics.


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