GL YCOHEM OG LOB IN AND INCIDENCE OF CORONARY HEART DISEASE
AbstractBackground: Presence of glucose on Hb1-c is established and represents a post translational glycosylation by a slownon-enzymatic process occurring during the 120 days’ life span of RBCs. It is an indicator of long term glycemiccontrol. Glycohemoglobin is directly related to blood glucose level. Methods: 50 randomly selected diabetic patientswere included and divided into two groups B and C of 25 subjects each. The subjects of group C were the diabeticswho were confirmed cases of CHD. while group B were the diabetics without any complications. Group A consistedof healthy controls (n=25). Glycohemoglobin was determined by column chromatography while blood glucose wasestimated by enzymatic method. Results: Blood glucose was increased in both the patient groups (p<0.001).Comparison of HbA| revealed a highly significant rise (p<0.001) in both the groups against normal control subjectsof group A. Correlation of Hb1-c with glucose in all the three groups was directly positive (r=+0.4). Conclusions: Theresults of the present study suggest an association between HbA1-c hyperglycemia and the incidence of CHD indiabetics.
Kennedy. L. and Lyons, T.J. (1989). Non enzymatic
glycosylation, Br. Med. Bull 45(9): 174-90.
Dunn, L, F. (1982). Hyperlipidemia and diabetes Med. Clin.
N. Am, 66(6): 1347.
Kenneth, H., Gabbay, K.H. Jan, 1... Breslow R. Curtis, E.H.,
Franklin, B. and Paul, M.G. (1977). Glycosylated
hemoglobin’s and long term blood glucose control in
diabetes mellitus. .1. tin Endocrinol Metah. 144(5): 859-64.
Mceance, D.R Hanson, R.L., Charles, M.A., Jacobson. L.T.H.
Pewttit. D. Benett. P.H. and Knowler. W.C (1994).
Comparison of tests for glycated hemoglobin and fasting and
two hours plasma glucose concentrations as diagnostic
methods for diabetes. B.M. J. 1323-8.
Gabhay. K. H. (1982). Glycosylated hemoglobin and diabetes
mellitus. symposium on diabetes mellitus. Med Clin. N. Am.
Kayaba, K., Nago, N., Miyamoto, T. and Mizooka, .VI.
(1989). Glycated hemoglobin levels and their correlation with
atherosclerotic risk factors in a Japanese population the Jichi
medical school Cohort study 1993-95. Jpn-Cir- J;62(4):261 -
Steffes, M.W. (1997). Glycemic control and the initiation and
progression of the complications of diabetes mellitus. KidneyInt- Suppl.63:936-9
Rehnian, J. and Rehman. VI. A. (1991). Studies on
glycosylated plasma proteins in diabetic patients J. Pak. Vied.
Assoc. 41(1): 15-8
Pickup, J.C., Mattock, VI.B.. Crook. M.A.. Chusney. G.D.,
Burt D. and Fitzgerald, A.P. (1995). Serum sialic acid
concentration and coronary artery disease in
NIDDVl. Diabetes care: 18(8): 11003-3.
Koeing, R.J., Peterson, C.M., Jones, R;L., Ssaudek, C.,
Lehrman, VI. and Carami. A. (1976). Correlation of glucose
regulation and hemoglobin Al-c in diabetes mellitus. N,
Engl. J. Med. 295:417-20
Jain, S.K., Movie, R., Jaramillo, J.J. and Chen. Y. (1998)
Hyperketonemia (aceto acetate) increase the oxidizability of
LDL & vldl IN TYPE-1 DIABETIC PATIENTS. Free
Martinez, O.M.A., Heranz, M.L., Martin, V.P., Macro, M.A.,
Grande, C., Alvero, Fetal. (1997). The metabolic control of
insulin-dependent diabetes mellitus and diabetic nephropathy.
(Abstract). Lin-Esp. 197(1): 18-22