GL YCOHEM OG LOB IN AND INCIDENCE OF CORONARY HEART DISEASE
Abstract
Background: Presence of glucose on Hb1-c is established and represents a post translational glycosylation by a slownon-enzymatic process occurring during the 120 days’ life span of RBCs. It is an indicator of long term glycemiccontrol. Glycohemoglobin is directly related to blood glucose level. Methods: 50 randomly selected diabetic patientswere included and divided into two groups B and C of 25 subjects each. The subjects of group C were the diabeticswho were confirmed cases of CHD. while group B were the diabetics without any complications. Group A consistedof healthy controls (n=25). Glycohemoglobin was determined by column chromatography while blood glucose wasestimated by enzymatic method. Results: Blood glucose was increased in both the patient groups (p<0.001).Comparison of HbA| revealed a highly significant rise (p<0.001) in both the groups against normal control subjectsof group A. Correlation of Hb1-c with glucose in all the three groups was directly positive (r=+0.4). Conclusions: Theresults of the present study suggest an association between HbA1-c hyperglycemia and the incidence of CHD indiabetics.References
Kennedy. L. and Lyons, T.J. (1989). Non enzymatic
glycosylation, Br. Med. Bull 45(9): 174-90.
Dunn, L, F. (1982). Hyperlipidemia and diabetes Med. Clin.
N. Am, 66(6): 1347.
Kenneth, H., Gabbay, K.H. Jan, 1... Breslow R. Curtis, E.H.,
Franklin, B. and Paul, M.G. (1977). Glycosylated
hemoglobin’s and long term blood glucose control in
diabetes mellitus. .1. tin Endocrinol Metah. 144(5): 859-64.
Mceance, D.R Hanson, R.L., Charles, M.A., Jacobson. L.T.H.
Pewttit. D. Benett. P.H. and Knowler. W.C (1994).
Comparison of tests for glycated hemoglobin and fasting and
two hours plasma glucose concentrations as diagnostic
methods for diabetes. B.M. J. 1323-8.
Gabhay. K. H. (1982). Glycosylated hemoglobin and diabetes
mellitus. symposium on diabetes mellitus. Med Clin. N. Am.
(6): 1301-
Kayaba, K., Nago, N., Miyamoto, T. and Mizooka, .VI.
(1989). Glycated hemoglobin levels and their correlation with
atherosclerotic risk factors in a Japanese population the Jichi
medical school Cohort study 1993-95. Jpn-Cir- J;62(4):261 -
Steffes, M.W. (1997). Glycemic control and the initiation and
progression of the complications of diabetes mellitus. KidneyInt- Suppl.63:936-9
Rehnian, J. and Rehman. VI. A. (1991). Studies on
glycosylated plasma proteins in diabetic patients J. Pak. Vied.
Assoc. 41(1): 15-8
Pickup, J.C., Mattock, VI.B.. Crook. M.A.. Chusney. G.D.,
Burt D. and Fitzgerald, A.P. (1995). Serum sialic acid
concentration and coronary artery disease in
NIDDVl. Diabetes care: 18(8): 11003-3.
Koeing, R.J., Peterson, C.M., Jones, R;L., Ssaudek, C.,
Lehrman, VI. and Carami. A. (1976). Correlation of glucose
regulation and hemoglobin Al-c in diabetes mellitus. N,
Engl. J. Med. 295:417-20
Jain, S.K., Movie, R., Jaramillo, J.J. and Chen. Y. (1998)
Hyperketonemia (aceto acetate) increase the oxidizability of
LDL & vldl IN TYPE-1 DIABETIC PATIENTS. Free
Radie-Biol-Me;24(l): 175-81.
Martinez, O.M.A., Heranz, M.L., Martin, V.P., Macro, M.A.,
Grande, C., Alvero, Fetal. (1997). The metabolic control of
insulin-dependent diabetes mellitus and diabetic nephropathy.
(Abstract). Lin-Esp. 197(1): 18-22
