CRYPTOSPORIDIOSIS AMONG CHILDREN OF DISTRICT SKARDU, PAKISTAN
AbstractBackground. Cryptosporidiosis is a common cause of persistent diarrhoea in children in developing countries. Previously it was thought to be a major pathogenic organism in immuno-compromised children, but recent studies have shown it to be a common infectious agent in immune-competent children as well. Methods. This descriptive case-series was carried out at Combined Military Hospital Skardu, Pakistan from August 2014 to June 2015. 53 children aged 12 months to 12 years with history of persistent watery diarrhoea for more than 2 weeks, with no blood or mucous in it and no other systemic findings, were included in the study. Results. We examined 53 stool specimen from children with persistent diarrhoea for the presence of cryptosporidium as well other pathogenic organisms. There were 22 (41.5%) females and 31 (58.5%) males. Out of 53 samples, 11 (20.8%) samples were found to be positive for cryptosporidium. Twenty-seven (50.9%) samples were found to be negative for any intestinal pathogen. Conclusion. It is concluded from this study that cryptosporidium is a very common infectious organism of persistent diarrhoea in this part of the country. Keywords. Persistent diarrhoea, cryptosporidium, ascariasis
WHO. Levels and trends in child mortality. Report 2013 [Internet]. [cited 2015 Aug 13]. Available from: http://www.who.int/maternal_child_adolescent/documents/levels_trends_child_mortality_2013/en/
Bonkoungou JO, Haukka K, Österblad M, Hakanen AJ, Traoré AS, Barro N, et al. Bacterial and viral etiology of childhood diarrhea in Ouagadougou, Burkina Faso. BMC Pediatr 2013;13:36.
O’Ryan M, Prado V, Pickering LK. A millennium update on pediatric diarrheal illness in the developing world. Semin Pediatr Infect Dis 2005;16(2):125–36.
Dillingham RA, Lima AA, Guerrant RL. Cryptosporidiosis: epidemiology and impact. Microbes Infect 2002;4(10):1059–66.
Khan WA, Rogers KA, Karim MM, Ahmed S, Hibberd PL, Calderwood SB, et al. Cryptosporidiosis among Bangladeshi children with diarrhea: A prospective, matched, case-control study of clinical features, epidemiology and systemic antibody responses. Am J Trop Med Hyg 2004;71(4):412–9.
6. Dozie I, Nkem B, Chukwuocha U. Cryptosporidiosis in Imo State, Nigeria. J Rural Trop Public Health 2011;10:106–10.
Smith HV, Girdwood RW, Patterson WJ, Hardie R, Green LA, Benton C, et al. Waterborne outbreak of cryptosporidiosis. Lancet 1988;2(8626-8627):1484.
Hart CA. Cryptosporidiosis. In: Gills HM, editor. Protozoal diseases. London: Arnold. 1999;592–606.
Framm SR, Soave R. Agents of diarrhoea. Med Clin North Am 1997;81(2):427–47.
Soave R, Armstrong D. Cryptosporidium and cryptosporidiosis. Rev Infect Dis 1986;8(6):1012–23.
Hassan KM, Ali FE, Bella MA. Cryptosporidiosis among children attending the maternity and paediatrics teaching hospital, Wad Medani, Central Region, Sudan. J Egypt Soc Parasitol 1991;21(1):213–8.
Janoff EN, Mead PS, Mead JR, Echeverria P, Bodhiditta L, Bhaibulaya M, et al. Endemic Cryptosporidium and Giardia infections in a Thai orphanage. Am J Trop Med Hyg 1990;43(3):248–56.
Moodley D, Jackson TE, Gathiram V, van-den-Ende J. Cryptosporidium infections in children in Durban. Seasonal variation, age distribution and disease status. S Afr Med J 1991;79(6):295–7.
Reinthaler FF, Mascher E, Sixl W, Enayat U, Marth E. Cryptosporidiosis in children in Idukki distric in southern India. J Diarrhoel Dis Res 1989;7(3-4):89–91.
Iqbal J, Munir MA, Khan MA. Cryptosporidium infection in young children with diarrhea in Rawalpindi, Pakistan. Am J Trop Med Hyg 1999;60(5):868–70.
Mumtaz S, Ahmed J, Ali L. Frequency of cryptosporidium infection in children under five years of age having diarrhea in the North West of Pakistan. Afr J Biotechnol 2010;9(8):1230–5.
Mahgoub ES, Almahbashi A, Abdulatif B. Cryptosporidiosis in children in a north Jordanian paediatric hospital. East Mediterr Heal J 2004;10(4-5):494–501.
Kotloff KL, Nataro JP, Blackwelder WC, Nasrin D, Farag TH, Panchalingam S, et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries )the Global Enteric Multicente Study, GEMS): a prospective, case-control study. Lancet 2013;382(9888):209–22.