• Muhammad Ali Rao Benazir Bhutto Hospital Rawalpindi Medical University
  • Naeem Raza Military Hospital Rawalpindi
  • Muhammad Faheem Holy Family Hospital
  • Muhammad Amer Saleem Department of Dermatology Benazir Bhutto Hospital Rawalpndi


Background: Scabies is a common dermatological presentation in Pakistan. Permethrin and Crotamiton both are used widely for treating scabies. As there is no local study available regarding comparison of efficacy of Permethrin and Crotamiton in patients of scabies, current study was undertaken. The objective of the study was to compare the efficacy of 5% Permethrin with 10% Crotamiton in patients of scabies. Methods: A Randomized control trial was conducted at Dermatology Department, Military Hospital, Rawalpindi. One hundred and sixty patients with scabies (diagnosis made by scraping the burrows to extract mite, larva or eggs and to see under light microscope) were randomly assigned either to Permethrin or Crotamiton group. Patients were followed over for 4 weeks to determine the effectiveness of either treatment. Results: A total of 160 patients were included in the study with a mean age of 45.49±17.047 years and ranging from 13–65 years. One hundred and one patients (63.1%) were male and remaining 59 patients (26.9%) were female. Treatment was effective in 81.3% patients being treated with 5% Permethrin and 53.8% in 10% Crotamiton group. Comparison of treatment showed superiority of 5% Permethrin over 10% Crotamiton (p=0.001). There was no effect of age and gender on this outcome difference. Conclusion: Our study concludes that 5% Permethrin cream is significantly superior to 10% Crotamiton cream in treating patients of scabies (81.3% vs. 53.8%, p=0.001).Keywords: Sacroptes Scabei; Permetherin; Crotamiton; Scabies

Author Biographies

Muhammad Ali Rao, Benazir Bhutto Hospital Rawalpindi Medical University

Senior Medical Officer, Department of DermatologyBenazir Bhutto HospitalRawalpindi Medical University

Naeem Raza, Military Hospital Rawalpindi

Brigadier Dr Naeem RazaClassified skin specialistMilitary HospitalRawalpindi

Muhammad Amer Saleem, Department of Dermatology Benazir Bhutto Hospital Rawalpndi

Postgraduate trainee (Dermatology)BBH, Rawalpindi


Patel VM, Lambert WC, Schwartz RA. Safety of Topical Medications for Scabies and Lice in Pregnancy. Indian J Dermatol 2016;61(6):583–87.

Thomas J, Peterson GM, Walton SF, Carson CF, Naunton M, Baby KE. Scabies: an ancient global disease with a need for new therapies BMC Infect Dis 2015;15:250.

Hay RJ, Steer AC, Engelman D, Walton S. Scabies in the developing world--its prevalence, complications, and management. Clin Microbiol Infect 2012;18(4):313–23.

Goldust M, Rezaee E, Raghifar R, Naghavi-Behzad M. Comparison of Permethrin 2.5 % cream vs. Tenutex emulsion for the treatment of scabies. Ann Parasitol 2013;59(1):31–5.

Shimose L, Munoz-Price LS. Diagnosis, prevention, and treatment of scabies. Curr Infect Dis Rep 2013;15(5):426–31.

Anderson KL, Strowd LC. Epidemiology, diagnosis, and treatment of scabies in a dermatology office. J Am Board Fam Med 2017;30(1):78–84.

Nair PA, Vora RV, Jivani NB, Gandhi SS. A Study of Clinical Profile and Quality of Life in Patients with Scabies at a Rural Tertiary Care Centre. J Clin Diagn Res 2016;10(10):WC01–5.

Monsel G, Chosidow O. Management of scabies. Skin Therapy Lett 2012;17(3):1–4.

Fang F, Bernigaud C, Candy K, Melloul E, Izri A, Durand R, et al. Efficacy assessmeny of biocides or repellents for the control of sarcoptes scabiei in the environment. Parasit Vectors 2015;8:416.

Pourhasan A, Goldust M, Rezaee E. Treatment of scabies , Permethrin 5 % cream vs Crotamiton 10 % cream. Ann Parasitol 2013;59(3):143–7.

Sekine R, Satoh T, Takaoka A, Saeki K, Yokozeki H. Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen induced scratching behavior. Exp Dermatol 2012;21(3):201–4.

Goldust M, Rezaee E, Raghiafar R. Topical ivermectin versus Crotamiton cream 10% for the treatment of scabies. Int J Dermatol 2014;53(7):904–8.

Dressler C, Rosumeck S, Sundekotter C, Werner RN, Nast A. The Treatment of Scabies. Dtsch Arztebl Int 2016;113(45):757–62.

Chosidow O. Clinical practices. Scabies. N Engl J Med 2006;354(16):1718–23.

Elmogy M, Fayed H, Marzok H, Rashad A. Oral ivermectin in the treatment of scabies. Int J Dermatol 1999;38(12):926–9.

Bukhari SA, Mann MA, Iqbal J. A randomized controlled trial to compare the efficiency of 1% lindane (scabene) cream and 5% permethrin (lotrix) cream for the treatment of scabies. J Pak Assoc Dermatol 2000;10:2–4.

Mushtaq A, Khurshid K, Pal SS. Comparison of efficacy and safety of oral ivermectin with topical permethrin in treatment of scabies. J Pak Assoc Dermatol 2016;20(4):227–31.



Most read articles by the same author(s)