GRANULOMATOSIS WITH POLYANGIITIS: A 17 YEAR EXPERIENCE FROM A TERTIARY CARE HOSPITAL IN PAKISTAN

Authors

  • Jaleed Ahmed Gilani Ziauddin University http://orcid.org/0000-0003-2769-2257
  • Muhammad Areeb Ashfaq Aga Khan University
  • Omar Irfan Hospital For Sick Children
  • Javaid Ahmed Khan Aga Khan University

Abstract

Granulomatosis with Polyangitis (GPA) is an uncommon immunologically mediated necrotizing vasculitis affecting the small and medium sized systemic blood vessels. We previously reported our experience with this condition and herein, we document our study findings and compare them to the clinical and radiological findings of various studies from around the world. By doing so we hope to further create awareness of this condition afflicting not only our part of the population but is part of a larger global phenomenon.Keywords: Vasculitis; Granulomatous Diseases; Lung

Author Biographies

Jaleed Ahmed Gilani, Ziauddin University

Intern

Muhammad Areeb Ashfaq, Aga Khan University

Intern

Omar Irfan, Hospital For Sick Children

Clinical Research Assistant, Department of Global Health, Peter Gilgan Center of Research and Learning

Javaid Ahmed Khan, Aga Khan University

Professor, Section of Pulmonology

References

Greco A, Marinelli C, Fusconi M, Macri GF, Gallo A, De Virgilio A, et al. Clinic manifestations in granulomatosis with polyangiitis. Int J Immunopathol Pharmacol 2016;29(2):151–9.

Ohshimo S, Guzman J, Costabel U, Bonella F. Differential diagnosis of granulomatous lung disease: clues and pitfalls: Number 4 in the Series "Pathology for the clinician" Edited by Peter Dorfmuller and Alberto Cavazza. Eur Respir Rev 2017;26(145):170012.

Irfan O, Khan H, Khan Z, Ashraf A, Ahmed R, Khan JA, et al. Granulomatosis with polyangiitis: a 17 year experience from a tertiary care hospital in Pakistan. BMC Res Notes 2018;11(1):303.

Shobha V, Fathima S, Prakash R. Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India. Clin Exp Med 2018;18(3):347–53.

Sharma A, Naidu G, Rathi M, Verma R, Modi M, Pinto B, et al. Clinical features and long-term outcomes of 105 granulomatosis with polyangiitis patients: A single center experience from north India. Int J Rheum Dis 2018;21(1):278–84.

Holle JU, Gross WL, Latza U, Nolle B, Ambrosch P, Heller M, et al. Improved outcome in 445 patients with Wegener's granulomatosis in a German vasculitis center over four decades. Arthritis Rheum 2011;63(1):257–66.

Stone JH. Limited versus severe Wegener's granulomatosis: baseline data on patients in the Wegener's granulomatosis etanercept trial. Arthritis Rheum 2003;48(8):2299–309.

Braham CA, White PJ, Arinaminpathy N. Management of tuberculosis by healthcare practitioners in Pakistan: A systematic review. PLoS One 2018;13(6):e0199413.

BMJ. Granulomatosis with polyangiitis (Wegener) [Internet]. [cited 2018 Dec]. Available from: https://online.epocrates.com/u/2935327/Granulomatosis+with+polyangiitis+(Wegener)/Diagnosis/Differential2018

Reinhold-Keller E, Beuge N, Latza U, de Groot K, Rudert H, Nolle B, et al. An interdisciplinary approach to the care of patients with Wegener's granulomatosis: long-term outcome in 155 patients. Arthritis Rheum 2000;43(5):1021–32.

Ferri E, Armato E, Capuzzo P, Cavaleri S, Ianniello F. Early diagnosis of Wegener's granulomatosis presenting with bilateral facial paralysis and bilateral serous otitis media. Auris Nasus Larynx 2007;34(3):379–82.

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Published

2019-07-30