• Ramchandani Ravi Jinnah Postgraduate Medical Centre Karachi
  • Ghulam Haider Jinnah Postgraduate Medical Centre
  • Khalil Ahmed Jinnah Postgraduate Medical Centre
  • Abdus Sami Jinnah Postgraduate Medical Centre
  • Saima Zahoor Jinnah Postgraduate Medical Centre
  • Ramchandani Lata Peoples Medical university,Shaheed Benazirabad


Background: This study was conducted to determine the frequency of amenorrhea after chemotherapy among breast cancer patients”. Methods: Total 201 premenopausal females (having menstruation during the past 6 months at the time of diagnosis) of age 15–45 years and had confirmed diagnosis of breast cancer requiring chemotherapy were included in the study using non-probability consecutive sampling technique. Amenorrhea within 6 months after the completion of chemotherapy was labelled as chemotherapy induced amenorrhea. Data was entered and analysed using SPSS-23. Results: The mean age of the patients was reported as 37.06±5.68 years. Majority of the females were married (86.6%) & multigravida (81.1%). Most of the patients (23.9%) received neoadjuvant chemotherapy followed by surgery and radiotherapy. A total of 129 patients received Adriamycin plus cyclophosphamide followed by paclitaxel as chemotherapy regimen. Out of 201 females, 184 (91.5%) experienced amenorrhea after start or completion of chemotherapy. Conclusion: The frequency of CIA was very high among breast cancer patients in our study, long term follow-up is needed to see input of CIA on future fertility.Keywords: Chemotherapy; amenorrhea; breast cancer; chemotherapy induced amenorrhea

Author Biographies

Ramchandani Ravi, Jinnah Postgraduate Medical Centre Karachi

oncology,postgraduate trainee

Ghulam Haider, Jinnah Postgraduate Medical Centre

Associate Professor,Medical Oncology

Khalil Ahmed, Jinnah Postgraduate Medical Centre

Consultant Medical Oncologist ,Medical Oncology .

Abdus Sami, Jinnah Postgraduate Medical Centre

Consultant Medical Oncologist ,Medical Oncology .

Saima Zahoor, Jinnah Postgraduate Medical Centre

Consultant Medical Oncologist ,Medical Oncology .

Ramchandani Lata, Peoples Medical university,Shaheed Benazirabad

Civil Hospital Tandoallahyar.Medical Officer


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