CORRELATION OF PREOPERATIVE VOLUME OF ORAL TONGUE SQUAMOUS CELL CARCINOMA (SCC) ON CT SCAN WITH POST-SURGICAL TUMOUR SIZE
Abstract
Background: Computed tomography (CT) radiological investigation is commonly used worldwide as a reliable method for determining the existence of oral tongue squamous cell carcinoma. This research was carried out to determine the correlation between the pre-surgical results of the CT scan and the size of the post-surgical tumour. Methods: An analytical cross-sectional study was conducted at the radiology department of Jinnah Post Graduate Medical Centre (JPMC), Karachi, Pakistan from May to October 2020. All patients aged 18 years or above of either gender having malignant tumours of the tongue already proven on biopsy were consecutively enrolled. Pre-surgery CT scan images were performed. The preoperative volume on CT scan then correlated with the post-surgical tumour size findings. The tumour thickness level of anterio-posterior (AP), transverse dimension (TS) and craniocaudal (CC) on pre-surgery CT scan and post-surgery tumour size were the outcome variables. Results: Of 84 patients, the mean age of the patients was 48.38 ±11.40 years. There were 56 (66.7%) males and 28 (33.3%) females. A moderate positive correlation of AP tumour size on CT scan was observed with post-surgical AP tumour size (r=0.671, p-value <0.001). Similarly, a moderate positive correlation of TS tumour size was observed with post-operative TS tumour size (r=0.692, p-value <0.001). While, a strong positive correlation of CC tumour size was observed with post-operative surgical tumour size (r=0.787, p-value <0.001). Conclusion: This study has reported a strong positive correlation of tumour thickness level on CT scan with post-surgical findings for determining the oral tongue squamous cell carcinoma.References
Chi AC, Day TA, Neville BW. Oral cavity and oropharyngeal squamous cell carcinoma—an update. CA Cancer J Clin 2015;65(5):401–21.
Bhurgri Y, Bhurgri A, Hassan SH, Zaidi SH, Rahim A, Sankaranarayanan R, et al. Cancer incidence in Karachi, Pakistan: first results from Karachi cancer registry. Int J Cancer 2000;85(3):325–9.
Anwar N, Pervez S, Chundriger Q, Awan S, Moatter T, Ali TS. Oral cancer: Clinicopathological features and associated risk factors in a high risk population presenting to a major tertiary care center in Pakistan. PloS One 2020;15(8):e0236359.
Ahmad Z, Idrees R, Fatima S, Uddin N, Ahmed A, Minhas K, et al. Commonest cancers in Pakistan-findings and histopathological perspective from a premier surgical pathology center in Pakistan. Asian Pac J Cancer Prev 2016;17(3):1061–75.
Been MJ, Watkins J, Manz RM, Gentry LR, Leverson GE, Harari PM, et al. Tumour volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. Laryngoscope 2008;118(8):1377–82.
Janssens GO, van Bockel LW, Doornaert PA, Bijl HP, van den Ende P, de Jong MA, et al. Computed tomography based tumour volume as a predictor of outcome in laryngeal cancer: results of the phase 3 ARCON trial. Eur J Cancer 2014;50(6):1112–9.
Studer G, Lutolf UM, El-Bassiouni M, Rousson V, Glanzmann C. Volumetric staging (VS) is superior to TNM and AJCC staging in predicting outcome of head and neck cancer treated with IMRT. Acta Oncol 2007;46(3):386–94.
Preis M, Hadar T, Soudry E, Shpitzer T, Strenov Y, Hod R, et al. Early tongue carcinoma: analysis of failure. Head Neck 2012;34(3):418–21.
Yuen AP, Ho CM, Chow TL, Tang LC, Cheung WY, Ng RW, et al. Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma. Head Neck 2009;31(6):765–72.
Hinerman RW, Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Villaret DB. Postoperative irradiation for squamous cell carcinoma of the oral cavity: 35-year experience. Head Neck 2004;26(11):984–94.
Ganly I, Goldstein D, Carlson DL. Long-term regional control and survival in patients with “low-risk”, early stage oral tongue cancer managed by partial glossectomy and neck dissection without postoperative radiation: the importance of tumour thickness. Cancer 2013;119(6):1168–76.
Iyer NG, Kim L, Nixon IJ. Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation. Head Neck 2013;35(7):999–1006.
Weimar EA, Huang SH, Lu L, O'Sullivan B, Perez-Ordonez B, Weinreb I, et al. Radiologic-Pathologic Correlation of Tumour Thickness and Its Prognostic Importance in Squamous Cell Carcinoma of the Oral Cavity: Implications for the Eighth Edition Tumour, Node, Metastasis Classification. Am J Neuroradiol 2018;39(10):1896–902.
Salman R, Hussain M, Adil SO. Diagnostic accuracy of Multislice CT scan in the detection of occult cervical lymph node metastasis in head and neck cancers. J Coll Physicians Surg Pak 2017;27(5):275–8.
Arya S, Rane P, Deshmukh A. Oral cavity squamous cell carcinoma: role of pretreatment imaging and its influence on management. Clin Radiol 2014;69(9):916–30.
Chinn SB, Myers JN. Oral cavity carcinoma: current management, controversies, and future directions. J Clin Oncol 2015;33(29):3269–76.
Park JO, Jung SL, Joo YH, Jung CK, Cho KJ, Kim MS. Diagnostic accuracy of magnetic resonance imaging (MRI) in the assessment of tumour invasion depth in oral/oropharyngeal cancer. Oral Oncol 2011;47(5):381–6.
Lwin CT, Hanlon R, Lowe D, Brown JS, Woolgar JA, Triantafyllou A, et al. Accuracy of MRI in prediction of tumour thickness and nodal stage in oral squamous cell carcinoma. Oral Oncol 2012;48(2):149–54.
Madana J, Laliberté F, Morand GB, Yolmo D, Black MJ, Mlynarek AM, et al. Computerized tomography based tumour-thickness measurement is useful to predict postoperative pathological tumour thickness in oral tongue squamous cell carcinoma. Otolaryngol Head Neck Surg 2015;44(1):1–4.
Khan SA, Zia S, Naqvi SU, Adel H, Adil SO, Hussain M. Relationship of Oral Tumour Thickness with the rate of lymph node metastasis in Neck based on CT Scan. Pak J Med Sci 2017;33(2):353–7.
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