MALARIA ENDEMICITY EFFECT ON COVID-19 PATHOPHYSIOLOGY: AN IN-SILICO PROTEIN-PROTEIN INTERACTION ANALYSIS
AbstractThe lower spread of COVID-19 in malaria endemic regions of world has been concluded in recent global COVID-19 data analysis. Scientists have compiled hypotheses about the relationships of these two infectious diseases; while some of those seem that have fully failed as malaria medications like Hydroxychloroquine were not effective in COVID-19 prevention. Our analysis of competition between ACE2 binding proteins as well as neutulizing SARS-Cov-2 antibodies revealed a similar structure to SARS-CoV-2 spike S1 protein in Plasmodium falciparum. Surprisingly, in an In-silico protein-protein interaction analysis, 20S proteasome alpha-4 subunit of Plasmodium falciparum had a better or equal binding affinity to ACE2 protein than SARS-CoV-2, based on a computational docking and MM/GBSA analysis. We hypothesized that prior encounter with Plasmodium falciparum in malaria endemic areas and the presence of asymptomatic variants of malaria in the body may render the human body to a competitive environment for SARS-CoV-2, as both infectious agents of malaria and SARS-Cov-2 may have a strong binding affinity to ACE2 protein. Keywords: malaria; COVID-19; Protein-Protein Interaction; vaccination
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.